A5033809150- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Exercise and Physiological Responses
- Cardiac Valve Diseases and Treatments
- Pregnancy and preeclampsia studies
- Sports Performance and Training
- Cardiovascular Issues in Pregnancy
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Cardiac Health and Mental Health
- Sports injuries and prevention
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiomyopathy and Myosin Studies
University of Westminster
2017-2023
St George's Hospital
2006-2020
South West London and St George's Mental Health NHS Trust
2009-2020
St George's Hospital
2008-2018
St George’s University Hospitals NHS Foundation Trust
2009-2018
St George's, University of London
2005-2017
National Health Service
2005-2016
Imperial College London
2003-2015
Institut Pasteur de Lille
2015
Health Service Executive
2015
Abstract OBJECTIVE We sought to determine the effect of patient selection on 99th reference percentile 2 sensitive and 1 high-sensitivity (hs) cardiac troponin assays in a well-defined population. METHODS Individuals >45 years old were randomly selected from 7 representative local community practices. Detailed information regarding participants was collected via questionnaires. The healthy population defined as individuals who had no history vascular disease, hypertension, or heavy...
Background— Ischemia modified albumin (IMA; Technologies, Inc) blood levels rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is not known whether IMA elevations correlate with increases other markers of oxidative stress, ie, 8-iso prostaglandin F2-A (iP). Methods and Results— We compared versus iP plasma 19 (mean age 62.8±11.9 years) undergoing PCI 11 64±13.6 diagnostic angiography (controls). In the patients, samples for were taken from guide...
Background Maternal perception of reduced fetal movement (RFM) is associated with increased risk stillbirth and growth restriction (FGR). RFM thought to represent compensation conserve energy due insufficient oxygen nutrient transfer resulting from placental insufficiency. Objective To identify predictors poor perinatal outcome after maternal movements (RFM). Design Prospective cohort study. Methods 305 women presenting 28 weeks gestation were recruited. Demographic factors clinical history...
Irbesartan, a long acting selective angiotensin-1 receptor inhibitor, in Marfan syndrome might reduce aortic dilatation, which is associated with dissection and rupture. We aimed to determine the effects of irbesartan on rate dilatation children adults syndrome.We did placebo-controlled, double-blind randomised trial at 22 centres UK. Individuals aged 6-40 years clinically confirmed were eligible for inclusion. Study participants all given 75 mg open label once daily, then randomly assigned...
The objective of this study was to examine the association between cortisol response mental stress and high-sensitivity cardiac troponin T (hs-cTnT) in healthy older individuals without history cardiovascular disease (CVD). Mental is a recognized risk factor for CVD, although mechanisms remain unclear. Cortisol, key hormone, associated with coronary atherosclerosis may accentuate structural functional disease. This cross-sectional involved 508 disease-free men women aged 53 76 years drawn...
Prolonged exercise has been shown to result in an acute depression cardiac function. However, little is known about the effect of this type on vascular Therefore, purpose present study was investigate impact bout prolonged strenuous and function appearance biomarkers cardiomyocyte damage 15 male (32 +/- 10 yr) nonelite runners. The subjects were tested two occasions, day before within hour finishing London marathon (229 38 min). Function brachial femoral arteries determined using...
Background. After renal transplantation half of all deaths are cardiac, so prior detection and treatment severe coronary artery disease (CAD) is advocated. The aim this study was to identify non-invasive predictors CAD in a group transplant candidates. Methods. One hundred twenty-five candidates (mean age 52±12 years, 80 male, mean creatinine 608±272 µmol/l) were studied. All had angiography, dobutamine stress echocardiography, resting exercise electrocardiograph (ECG). Severe defined as...
To comprehensively investigate the cardiovascular consequences of a 160-km ultramarathon using traditional echocardiography, speckle tracking imaging, cardiac biomarkers, and heart rate variability (HRV) to examine relationship between changes in these variables.We examined athletes before an reassessed all finishers immediately after race. Left ventricular (LV) systolic (ejection fraction [EF], blood pressure/end-systolic volume [SBP/ESV] ratio) diastolic (ratio early [E] late [A], filling...
Ischemia-modified albumin (IMA) is a new marker of myocardial ischemia, there concern that IMA concentrations may be affected by ischemia occurring in tissues other than the myocardium.We assessed 23 consecutive patients (15 males; mean age, 67 years) with typical leg claudication and documented peripheral vascular disease (PVD). All underwent both treadmill-exercise stress testing to induce dobutamine echocardiography 1 week apart for assessment ischemia. Blood samples measurements were...
The purpose of this investigation was to, firstly, examine the effects repeated applications ice massage on indirect markers associated with muscle damage using a within‐subjects cross‐over design and secondly, to how affects function in both static dynamic contractions following unaccustomed eccentric exercise. Twelve males performed damaging exercise two separate occasions. protocol consisted three sets 10 maximal repetitions elbow flexors isokinetic dynamometry. Subjects were randomly...
We assessed segmental and global left ventricular (LV) diastolic function via tissue‐Doppler imaging (TDI) as well Doppler flow variables before after a marathon race to extend our knowledge of exercise‐induced changes in cardiac function. Twenty‐nine subjects (age 18–62 year) volunteered participate were pre‐ post‐race. Measurements longitudinal plane TDI myocardial velocities at five sites on the mitral annulus included peak early tissue velocity ( E ′), late (or atrial) A ′) ratio ′/ ′....
The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male nine female; age, 35±10 years; height, 1.74±0.08 m; body mass, 75.9±8.9 kg) were assessed pre- immediately post-marathon. function was using standard M-mode two-dimensional Doppler echocardiography TDI (tissue-Doppler imaging) echocardiography. Serum analysed for cTnT (cardiac...