A5060254611- Health disparities and outcomes
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Mental Health Treatment and Access
- Memory and Neural Mechanisms
- Employment and Welfare Studies
- Facial Nerve Paralysis Treatment and Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Ear Surgery and Otitis Media
- Neuroscience and Neuropharmacology Research
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Nasal Surgery and Airway Studies
- Health, psychology, and well-being
- Cardiovascular Health and Risk Factors
- Adolescent and Pediatric Healthcare
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal pain and rehabilitation
- Vaccine Coverage and Hesitancy
- Adipokines, Inflammation, and Metabolic Diseases
- Esophageal Cancer Research and Treatment
- Adipose Tissue and Metabolism
University College London
2012-2023
Imperial College London
2010-2023
King's College London
2018
London School of Hygiene & Tropical Medicine
2016-2017
National Hospital for Neurology and Neurosurgery
2017
Ghent University
2015
University College Cork
2015
Federico II University Hospital
2015
Agenzia Regionale Parchi
2009
Regione Lazio
2009
Significance Our observations provide evidence to link epidemiological studies implicating stress-related processes with biological dysfunction in type 2 diabetes. The patterns of cardiovascular, inflammatory, neuroendocrine, and cholesterol responses exemplify the disturbances reactivity recovery predicted by allostatic load model, including prolonged stress due delayed shutdown physiological reactivity, inadequate (blunted) resulting compensatory hyperactivity other mediating pathways....
Background The purpose of this study was to test whether lower socioeconomic status (SES) augments the effect psychological distress on mortality from stroke or coronary heart disease (CHD). Methods We prospectively linked data 66,500 participants 35 years older in Health Survey for England, selected using stratified random sampling 1994 2004, and free cardiovascular cancer at baseline, with records. median follow-up time 7.9 years. SES indexed by occupational class, assessed 12-item General...
The objective of this study was to examine the association between cortisol response mental stress and high-sensitivity cardiac troponin T (hs-cTnT) in healthy older individuals without history cardiovascular disease (CVD). Mental is a recognized risk factor for CVD, although mechanisms remain unclear. Cortisol, key hormone, associated with coronary atherosclerosis may accentuate structural functional disease. This cross-sectional involved 508 disease-free men women aged 53 76 years drawn...
In Brief Objective: To assess the trends in uptake of minimal invasive esophagectomy England over last 12 years (1996/1997–2007/2008) and to compare their clinical outcomes with those after open esophagectomy. Summary Background Data: Around 7400 people are affected each year United Kingdom. Prognosis following esophageal resection is, however, poor. Even "curative" surgery, 5-year survival rates do not exceed 25%. The minimally approach has attracted attention as a potentially less...
<b>Objectives</b> To describe national trends in bariatric surgery and examine the factors influencing outcome England. <b>Design</b> Observational population cohort study. <b>Setting</b> Hospital Episode Statistics database. <b>Participants</b> All patients who had primary gastric bypass, banding, or sleeve gastrectomy procedures between April 2000 March 2008. <b>Main measures</b> 30 day mortality, mortality at one year after surgery, unplanned readmission to hospitalwithin 28 days,...
To assess short- and long-term effects of rapid maxillary expansion (RME) on nasal flow in young children. Since RME has been reported to positively influence obstruction subjects with respiratory problems by reducing resistance, a similar efficacy could be expected children deciduous and/or mixed dentition who are affected constriction from different cause.Prospective study younger than 12 years, grades malocclusion oral breathing. Data included active anterior rhinomanometry both the...
Background: Psychological distress and low socioeconomic status (SES) are recognized risk factors for mortality.The aim of this study was to test whether lower SES amplifies the effect psychological on all-cause mortality.Methods: We selected 66 518 participants from Health Survey England who were 35 years or older, free cancer cardiovascular disease at baseline, living in private households 1994 2004.Selection used stratified random sampling, linked prospectively mortality records Office...
Abstract Background Common mental disorders (CMDs) including depression, anxiety, and stress are very common, but it is unclear whether the last decades of social, economic, political change have impacted incidence CMD. This study explored temporal trends in recorded CMD United Kingdom. Methods We used data from general practices Kingdom (Clinical Practice Research Datalink) to estimate annual for 2000–2020, symptoms, diagnosis, or pharmaceutical treatment. Trends were by sex, age,...
Psychological stress may contribute to type 2 diabetes but mechanisms are still poorly understood. In this study, we examined whether responsiveness is associated with glucocorticoid and mineralocorticoid sensitivity in a controlled experimental comparison of people non-diabetic participants. Thirty-seven patients 37 healthy controls underwent psychophysiological testing. Glucocorticoid (GR) (MR) were measured by dexamethasone- prednisolone-inhibition lipopolysaccharide (LPS)-induced...
Most research on the influence of psychosocial job characteristics health status has been conducted within affluent Western economies. This addresses same topic in a middle-income Southeast Asian country, enabling comparison with benchmark.We analysed and compared Health Survey for England 2010 Thai Cohort Study data at 2005 baseline workers aged 35-45 years. Multivariate logistic regression was used to assess relationships between health, measured as Adjusted Odd Ratios (AOR), controlling...
Post-traumatic stress disorder (PTSD) involves maladaptive long-term memory formation which underlies involuntary intrusive thoughts about the trauma. Preventing development of such is a key aim in preventing PTSD. We examined whether N-methyl d-aspartate receptor (NMDAR) antagonist gas nitrous oxide (N2O) could reduce frequency memories by inhibiting NMDAR-dependent consolidation laboratory analogue psychological trauma.Participants were randomized to inhale N2O (N = 25) or medical air...
Conclusion: Rehabilitation was significantly efficient in both groups of patients with synkinesis, especially those whom treatment botulinum toxin type A (BTX-A) preceded physical rehabilitation. Objective: To determine the influence preventive BTX-A on synkinesis when rehabilitation is planned. Methods: Twenty patients, who recovered from facial palsy final House-Brackmann (HB) grade II and III, were randomized to assess efficacy score after Synkinesis graded according four-point scale...
Preclinical reconsolidation research offers the first realistic opportunity to pharmacologically weaken maladaptive memory structures that support relapse in drug addicts. N-methyl D-aspartate receptor (NMDAR) antagonism is a highly effective means of blocking reconsolidation. However, no using this approach exists human addicts.The objective study was assess potential and clinical outcomes cue-smoking memories with memantine quitting smokers.Fifty-nine dependent motivated quit smokers were...
Background According to clinical guidelines, every patient affected by stroke should be given a brain-imaging scan (BIS) - Computerized Tomography or Magnetic Resonance Imaging immediately after being admitted hospital. Aim of the study To describe variation in use BIS among English public hospitals and identify any groups excluded from appropriate care. Methods We collected hospital administrative data for all patients with principal diagnosis 2006 2009. calculated proportion treated whole...
Socioeconomic status is a recognised determinant of health status, and the association may be mediated by unhealthy behaviours psychosocial adversities, which, in developed countries, both aggregate low socioeconomic sectors population. We explored hypothesis that behavioural choices psychological distress do not groups developing countries. Our study based on cross-sectional comparison between national population samples adults England Thailand. Psychological was assessed using General...
Transfusion-dependent patients typically develop iron-induced cardiomyopathy, liver disease, and endocrine complications. We aimed to estimate the incidence of disorders in transfusiondependent thalassemia (TDT) during long-term iron-chelation therapy with deferasirox (DFX). developed a multi-center follow-up study 426 TDT treated once-daily DFX for median duration 8 years, up 18.5 years. At baseline, 118, 121, 187 had 0, 1, or ≥2 diseases respectively. 104 additional were follow-up. The...