A5054793940- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Thermoregulation and physiological responses
- Cardiovascular Health and Disease Prevention
- Cardiac Ischemia and Reperfusion
- Blood Pressure and Hypertension Studies
- Cardiac Arrest and Resuscitation
- Infrared Thermography in Medicine
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Physical Activity and Health
- Exercise and Physiological Responses
- Sports Performance and Training
- Cardiac Health and Mental Health
- Cardiovascular Disease and Adiposity
- Sleep and related disorders
- Cardiovascular Effects of Exercise
- Circadian rhythm and melatonin
- Anesthesia and Neurotoxicity Research
- Cardiovascular Syncope and Autonomic Disorders
- Mobile Health and mHealth Applications
- Climate Change and Health Impacts
- Sleep and Wakefulness Research
- Liver Disease and Transplantation
Liverpool John Moores University
2016-2025
University of Liverpool
1992-2025
Liverpool Heart and Chest Hospital
2025
Transnational Press London
2024
NHS Lothian
2022-2023
English Institute of Sport
2023
Kelowna General Hospital
2022
Western General Hospital
2022
Royal Society for the Protection of Birds
2018-2021
University of Oxford
2021
Nonalcoholic fatty liver disease may be evident in women with polycystic ovary syndrome (PCOS), both conditions being associated obesity and insulin resistance. However, few studies have accounted for the high prevalence of PCOS. The aim this study was to determine whether PCOS is independently hepatic steatosis, compared healthy controls similar age body mass index (BMI), steatosis hyperandrogenemia. We conducted a cross-sectional, case-control at two tertiary referral centers. Twenty-nine...
Purpose Repeated bouts of ischemia followed by reperfusion (i.e., ischemic preconditioning (IPC)) protect against damage after a myocardial infarction. Recent observational data indicate that IPC improves exercise performance. However, no previous study has examined potential underlying mechanisms for this effect IPC. Therefore, we the to improve 5-km running time trial performance and reduce lactate accumulation during an incremental test. Methods In randomized, crossover study, 13 healthy...
Cold water immersion reduces exercise-induced muscle damage. Benefits may partly arise from a decline in limb blood flow; however, no study has comprehensively investigated the influence of different degrees cooling undertaken via cold on flow responses.To determine (8°C) and cool (22°C) lower cutaneous flow.Controlled laboratory study.Nine men were placed semireclined position lowered into 8°C or 22°C to iliac crest for two 5-minute periods interspersed with 2 minutes nonimmersion. Rectal...
Simple clinical algorithms including the fatty liver index (FLI) and lipid accumulation product (LAP) have been developed as surrogate markers for non-alcoholic disease (NAFLD), constructed using (semi-quantitative) ultrasonography. This study aimed to validate FLI LAP measures of hepatic steatosis, determined quantitatively by proton magnetic resonance spectroscopy (1H-MRS).Data were collected from 168 patients with NAFLD controls who had undergone clinical, biochemical anthropometric...
Non-alcoholic fatty liver disease (NAFLD) is associated with multi-organ (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise an effective treatment for lowering fat but its effect on IR in NAFLD unknown. We aimed to determine whether supervised exercise would reduce and improve hepatic peripheral (skeletal muscle sensitivity. Sixty nine patients were randomized 16 weeks supervision (n=38) or counselling (n=31) without dietary modification. All participants underwent...
Strenuous exercise is associated with an immediate decrease in endothelial function. Repeated bouts of ischemia followed by reperfusion, known as remote ischemic preconditioning (RIPC), able to protect the endothelium against ischemia-induced injury beyond area. We examined hypothesis that RIPC prevents function observed after strenuous healthy men. In a randomized, crossover study, 13 men performed running preceded lower limbs (4 × 5-min 220-mmHg bilateral occlusion) or sham intervention...
Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular (CVD). Endothelial dysfunction early manifestation of atherosclerosis and important prognostic marker future events. The aim this study was twofold: to examine 1) the association between fat, visceral adipose tissue (VAT), endothelial in obese NAFLD patients 2) impact supervised exercise training on vascular defect. Brachial artery function assessed by flow-mediated dilatation (FMD) 34 20 controls...
Endothelial function, assessed using brachial artery flow-mediated dilation (FMD), predicts future cardiovascular disease (CVD) risk. This study established age- and sex-specific reference intervals for FMD in healthy individuals examined the relation with CVD risk factors. In a retrospective design, we pooled (acquired according to expert-consensus guidelines protocol analysis) participant characteristics/medical history from 5362 (4–84 years; 2076 females). Healthy (n=1403 [582 females])...
Prolonged exercise has been shown to result in an acute depression cardiac function. However, little is known about the effect of this type on vascular Therefore, purpose present study was investigate impact bout prolonged strenuous and function appearance biomarkers cardiomyocyte damage 15 male (32 +/- 10 yr) nonelite runners. The subjects were tested two occasions, day before within hour finishing London marathon (229 38 min). Function brachial femoral arteries determined using...
It has been deemed important to normalize flow-mediated dilation (FMD), a marker of endothelial function, for between-subject differences in the eliciting shear rate (SR) stimulus. Conventionally, FMD is divided by area under curve SR In context cross-sectional comparison across different age cohorts, we examined whether this ratio approach adhered established statistical assumptions necessary reliable normalization. To quantify brachial artery and SR, forearm cuff inflation suprasystolic...
The objectives of our study were to examine 1) the proportion responders and nonresponders exercise training in terms vascular function; 2) a priori factors related training-induced changes conduit artery function, 3) contribution traditional cardiovascular risk exercise-induced function. We pooled data from laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type interventions with pre-/posttraining measures flow-mediated dilation (FMD%) assess All...
This study aimed to determine the influence of cold (8°C) and cool (22°C) water immersion on femoral artery cutaneous blood flow after exercise.Twelve men completed a continuous cycle exercise protocol at 70% peak oxygen uptake until core temperature 38°C was attained. Subjects were then immersed semireclined into 8°C or 22°C iliac crest for 10 min rested. Rectal thigh skin temperature, deep superficial muscle calf (laser Doppler flowmetry), (duplex ultrasound) measured before up 30...
BackgroundIschaemic preconditioning has well-established cardiac and vascular protective effects. Short interventions (one week) of daily ischaemic episodes improve conduit microcirculatory function. This study examined whether a longer (eight weeks) less frequent (three per protocol repeated improves
Introduction Adherence to unsupervised exercise is poor, yet interventions are utilised in most healthcare settings. Thus, investigating novel ways enhance adherence essential. This study aimed examine the feasibility of two mobile health (mHealth) technology–supported and physical activity (PA) increase exercise. Methods Eighty-six participants were randomised online resources ( n = 44, females 29) or MOTIVATE 42, 28). The group had access booklets videos assist performing a progressive...
Blood pressure (BP) fluctuates over a 24-hour period, but it is unclear to what extent this variation governed completely by changes in physical activity. Our aim was use BP "reactivity index" investigate whether the response given level of activity during normal sleep-wake cycle. Hypertensive patients (n=440) underwent simultaneous ambulatory BP, heart rate (HR), and monitoring. HR were measured every 20 minutes. Actigraphy data averaged 15 minutes that preceded measurement. Individual...
It is currently unclear to what extent diurnal variation and exercise effect endothelium-dependent nitric oxide (NO)-mediated vasodilation. Therefore, we measured brachial artery flow-mediated dilation (FMD) in 10 males (mean age = 28 yr, SD 7), before after a bout of intermittent cycling at 70% peak oxygen uptake on separate days beginning either 0800 or 1600. Edge-detection wall-tracking software was used measure changes arterial diameter, while shear rate (SR) assessed using...
The leading causes of mortality in nonalcoholic fatty liver disease (NAFLD) relate to cardiovascular (CVD). contribution nitric oxide (NO) endothelial function, a surrogate CVD risk, is currently unknown NAFLD. We hypothesize that NO-mediated cutaneous microvessel function would be impaired NAFLD compared with controls and exercise enhance conventional care. Thirteen patients (aged 50 ± 3 yr, BMI 31 1 kg/m 2 ) seven (48 4 30 were studied. randomized either 16 wk or Cutaneous was examined...