A5021159651- Cardiovascular Health and Disease Prevention
- Cardiovascular and exercise physiology
- Thermoregulation and physiological responses
- Heart Rate Variability and Autonomic Control
- Menopause: Health Impacts and Treatments
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Cancer survivorship and care
- Aortic aneurysm repair treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Climate Change and Health Impacts
- Infrared Thermography in Medicine
- Cardiac Health and Mental Health
- Optical Imaging and Spectroscopy Techniques
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Disease and Adiposity
- Physical Activity and Health
- Cardiac Ischemia and Reperfusion
- Peripheral Artery Disease Management
- Cardiac Arrest and Resuscitation
- Sports Performance and Training
- Fatty Acid Research and Health
- Hormonal and reproductive studies
The University of Queensland
2017-2025
University of Toronto
2016-2024
Mater Research
2022-2023
Nutrition Sciences (Belgium)
2017-2022
University of the Sunshine Coast
2015-2022
Anderson University - South Carolina
2021
McCarthy Family Foundation
2021
Society of Surgical Oncology
2019
Liverpool John Moores University
2012-2016
Waikato Hospital
2016
Purpose Repeated bouts of ischemia followed by reperfusion (i.e., ischemic preconditioning (IPC)) protect against damage after a myocardial infarction. Recent observational data indicate that IPC improves exercise performance. However, no previous study has examined potential underlying mechanisms for this effect IPC. Therefore, we the to improve 5-km running time trial performance and reduce lactate accumulation during an incremental test. Methods In randomized, crossover study, 13 healthy...
Ischemic preconditioning (IPC) protects tissue against ischemia-induced injury inside and outside ischemic areas. The purpose was to examine the hypothesis that daily IPC leads improvement in endothelial function skin microcirculation not only arm exposed but also contralateral arm. Thirteen healthy, young, normotensive male individuals (aged 22±2 years) were assigned 7-day exposure of (4×5 minutes). Assessment brachial artery (using flow-mediated dilation (FMD)) forearm (cutaneous vascular...
Strenuous exercise is associated with an immediate decrease in endothelial function. Repeated bouts of ischemia followed by reperfusion, known as remote ischemic preconditioning (RIPC), able to protect the endothelium against ischemia-induced injury beyond area. We examined hypothesis that RIPC prevents function observed after strenuous healthy men. In a randomized, crossover study, 13 men performed running preceded lower limbs (4 × 5-min 220-mmHg bilateral occlusion) or sham intervention...
<h3>Importance</h3> High-intensity interval training (HIIT) is recognized as a potent stimulus for improving cardiorespiratory fitness (volume of oxygen consumption [VO<sub>2</sub>] peak) in patients with coronary artery disease (CAD). However, the feasibility, safety, and long-term effects HIIT this population are unclear. <h3>Objective</h3> To compare moderate-intensity continuous (MICT) adherence, efficacy VO<sub>2</sub>peak CAD. <h3>Design, Setting, Participants</h3> In single-center...
Endothelial function, assessed using brachial artery flow-mediated dilation (FMD), predicts future cardiovascular disease (CVD) risk. This study established age- and sex-specific reference intervals for FMD in healthy individuals examined the relation with CVD risk factors. In a retrospective design, we pooled (acquired according to expert-consensus guidelines protocol analysis) participant characteristics/medical history from 5362 (4–84 years; 2076 females). Healthy (n=1403 [582 females])...
Abdominal aortic aneurysm (AAA) is associated with inflammation and oxidative stress, the latter of which contributes to activation macrophages, a prominent cell type in AAA. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported limit stress animal models The aim this study was evaluate effect n-3 PUFA docosahexaenoic acid (DHA) on antioxidant defence macrophages from patients Cells were obtained men small AAA (diameter 3.0-4.5 cm, 75 ± 6 yr, n = 19) age- matched male controls...
BackgroundIschaemic preconditioning has well-established cardiac and vascular protective effects. Short interventions (one week) of daily ischaemic episodes improve conduit microcirculatory function. This study examined whether a longer (eight weeks) less frequent (three per protocol repeated improves
Markers of chronic inflammation increase with aging, and are associated cardiovascular disease prevalence mortality. Increases in fitness exercise training have been lower circulating concentrations cytokines known to pro-inflammatory actions (such as interleukin-6 [IL-6]) higher anti-inflammatory (interleukin-10 [IL-10]). However, the effect cardiorespiratory on acute cytokine responses a single bout healthy older individuals is unknown. We compared response plasma IL-6, tumor necrosis...
Neurovascular coupling (NVC) is the matching between local neuronal activity and regional cerebral blood flow (CBF), but little known about effects of age sex on NVC. This study aimed to investigate relationships interaction Sixty-four healthy adults (18–85 years, N = 34 female) completed a visual stimulus evoked NVC assessment flashing checkerboard. responses were measured in posterior artery (PCAv) using transcranial Doppler ultrasound. A hierarchical multiple regression was used determine...
Exercise training has the potential to enhance cerebrovascular function. Warm water immersion recently been shown vascular function including response heating. We suggest that passive heating can be used alternatively exercise. Our aim was compare effects of exercise with warm-water on and thermoregulatory 18 females (25±5 y) performed 8 weeks cycling (70% HR<sub>max</sub>) or warm (42°C) for 30 min 3 times per week. Brachial artery flow-mediated dilation (FMD) peak cardiorespiratory fitness...
Aging is often associated with reduced leg blood flow, increased arterial stiffness, and endothelial dysfunction, all of which are related to declining nitric oxide (NO) bioavailability. Flow mediated dilatation (FMD) passive movement (PLM) hyperaemia two techniques used measure NO-dependent vascular function. We hypothesised that acute dietary nitrate (NO3−) supplementation would improve NO bioavailability, FMD, PLM hyperaemia. Fifteen healthy older men (69 ± 4 years) attended experiment...
Peripheral arterial disease (PAD) is characterized by stenosis and occlusion of the lower limb arteries. Although leg blood flow limited in PAD, it remains unclear whether skeletal muscle microvascular perfusion affected. We compared whole calf after cuff submaximal exercise between patients with PAD ( n = 12, 69 ± 9 yr) healthy age-matched control participants 68 7 yr). Microvascular (microvascular volume × velocity) medial gastrocnemius was measured before immediately following: 1) 5 min...
Postmenopausal hot flushes occur due to a reduction in estrogen production causing thermoregulatory and vascular dysfunction. Exercise training enhances control of sweating, skin brain blood flow. We aimed determine if improving function with exercise alleviated flushes.Twenty-one symptomatic women completed 7-day flush questionnaire underwent brachial artery flow-mediated dilation cardiorespiratory fitness test. Sweat rate flow temperature thresholds sensitivities, middle cerebral velocity...
Endothelial dysfunction is observed in patients with abdominal aortic aneurysm (AAA), who have increased risk of cardiovascular events and mortality. This study aimed to assess the acute effects moderate- higher-intensity exercise on endothelial function, as assessed by flow-mediated dilation (FMD), AAA (74 ± 6 yr old, n = 22) healthy adults (72 5 22). Participants undertook three randomized visits, including moderate-intensity continuous [40% peak power output (PPO)], interval (70% PPO), a...
Abstract It is now well established that vascular aging a significant predictor of cognitive decline in older age. But what remains less clear the role health plays social aging. Therefore, we aimed to provide first test relationship between arterial stiffness and theory mind (ToM) late adulthood. In sample 50 healthy adults (Age: M = 70.08, SD 3.93), measured via carotid-femoral pulse wave velocity cognition using two validated measures ToM (RMET, TASIT). The results revealed was...
ABSTRACT Context Gynecological cancer treatment can detrimentally affect physical and mental well-being by compromising physical, functional, emotional quality of life, despite the eradication tumor, limit return to pretreatment health function. Exercise after might offset these outcomes enhance overall yet women treated for gynecological remain largely inactive, with a significant proportion failing meet recommended activity guidelines. Structured, supervised exercise in this cohort is...
ABSTRACT Purpose Aging is associated with impaired cerebral blood flow (CBF) and increased risk of cerebrovascular disease. Acute increases in CBF during exercise may initiate improvements health, but the response diminished continuous older adults. The effect interval for promoting young old adults unknown. Methods We compared middle artery velocity (MCAv), end-tidal CO 2 (P ET ) pressure (mean arterial [MAP]) intensity- work-matched bouts (10-min 60% W max , followed by 10-min rest)...
Evidence of prospective associations between participation in sports and recreational activities (SRAs) health outcomes at the population level is scarce. We investigated SRAs 6‐year incidence hypertension, diabetes, obesity a cohort mid‐age Australian adults. analyzed data from HABITAT study (n = 8784), adults aged 40+ years living Brisbane, Australia. Mail surveys 2007, 2009, 2011, 2013 were used to collect on 11 past 12 months, as well self‐reported height, weight. Obesity was defined BMI...
Abstract Purpose We compared the effects of low-volume combined aerobic and resistance high-intensity interval training (C-HIIT), moderate-intensity continuous (C-MICT) waitlist control (CON) on vascular health after 8-weeks supervised training, an additional 10-months self-directed in adults with type 2 diabetes (T2D). Methods Sixty-nine low active T2D were randomised to C-HIIT (3 times/week, 78-min/week), C-MICT (current exercise guidelines, 4 210-min/week) or CON. CON underwent usual care...
Impaired endothelial function is observed with aging and in those low cardiorespiratory fitness (V̇o 2peak ). Improvements exercise training are somewhat dependent on the intensity of exercise. While acute stimulus for this improvement not completely understood, it may, part, be due to flow-mediated dilation (FMD) response We examined hypothesis that alters brachial (systemic) FMD elderly men modulated by V̇o . Forty-seven were stratified into lower = 24.3 ± 2.9 ml·kg −1 ·min ; n 27) higher...