A5083881922- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Blood Pressure and Hypertension Studies
- Fatty Acid Research and Health
- Aesthetic Perception and Analysis
- Photography and Visual Culture
- Cardiovascular and exercise physiology
- Macrophage Migration Inhibitory Factor
- Ethics, Aesthetics, and Art
- Visual Culture and Art Theory
- Heart Rate Variability and Autonomic Control
- Peripheral Artery Disease Management
- Immune cells in cancer
- Cinema and Media Studies
- Philosophical Ethics and Theory
- Educator Training and Historical Pedagogy
- Educational Strategies and Epistemologies
- Media Influence and Health
- Sports Performance and Training
- American Constitutional Law and Politics
- Platelet Disorders and Treatments
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Kierkegaardian Philosophy and Influence
- Geographies of human-animal interactions
University of the Sunshine Coast
2017-2025
University of Southampton
2024
Masaryk University
2023
Canterbury Christ Church University
2023
Sunshine Coast University Hospital
2021-2022
Northeastern University London
2020
University of Kent
2014-2019
Abdominal aortic aneurysm (AAA) is associated with inflammation and oxidative stress, the latter of which contributes to activation macrophages, a prominent cell type in AAA. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported limit stress animal models The aim this study was evaluate effect n-3 PUFA docosahexaenoic acid (DHA) on antioxidant defence macrophages from patients Cells were obtained men small AAA (diameter 3.0-4.5 cm, 75 ± 6 yr, n = 19) age- matched male controls...
Markers of chronic inflammation increase with aging, and are associated cardiovascular disease prevalence mortality. Increases in fitness exercise training have been lower circulating concentrations cytokines known to pro-inflammatory actions (such as interleukin-6 [IL-6]) higher anti-inflammatory (interleukin-10 [IL-10]). However, the effect cardiorespiratory on acute cytokine responses a single bout healthy older individuals is unknown. We compared response plasma IL-6, tumor necrosis...
Introduction Patients with peripheral artery disease (PAD) can experience intermittent claudication, which limits walking capacity and the ability to undertake daily activities. While exercise therapy is an established way improve in people PAD, it not feasible all patients. Neuromuscular electrical stimulation (NMES) provides a passively induce repeated muscle contractions has been widely used as for chronic conditions that limit functional capacity. Preliminary trials patients PAD...
Endothelial dysfunction is observed in patients with abdominal aortic aneurysm (AAA), who have increased risk of cardiovascular events and mortality. This study aimed to assess the acute effects moderate- higher-intensity exercise on endothelial function, as assessed by flow-mediated dilation (FMD), AAA (74 ± 6 yr old, n = 22) healthy adults (72 5 22). Participants undertook three randomized visits, including moderate-intensity continuous [40% peak power output (PPO)], interval (70% PPO), a...
Impaired endothelial function is observed with aging and in those low cardiorespiratory fitness (V̇o 2peak ). Improvements exercise training are somewhat dependent on the intensity of exercise. While acute stimulus for this improvement not completely understood, it may, part, be due to flow-mediated dilation (FMD) response We examined hypothesis that alters brachial (systemic) FMD elderly men modulated by V̇o . Forty-seven were stratified into lower = 24.3 ± 2.9 ml·kg −1 ·min ; n 27) higher...
Glycine receptors (GlyRs) containing the α2 subunit govern cell fate, neuronal migration and synaptogenesis in developing cortex spinal cord. Rare missense variants microdeletions X-linked GlyR gene (GLRA2) have been associated with human autism spectrum disorder (ASD), where they typically cause a loss-of-function via protein truncation, reduced cell-surface trafficking and/or glycine sensitivity (e.g., GLRA2Δex8-9 extracellular domain p.N109S p.R126Q). However, variant p.R323L...
Purpose Inflammation and extracellular matrix degeneration contribute to abdominal aortic aneurysm (AAA) development. We aimed assess the effect of exercise intensity on circulating biomarkers inflammation in patients with AAA healthy older adults. Methods Twenty (74 ± 6 yr) 20 males (72 5 completed moderate-intensity cycling at 40% peak power output, higher-intensity intervals 70% control (rest) separate days. Circulating metalloproteinase-9 (MMP-9), transforming growth factor beta 1,...
Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte content 43 AAA patients (diameter 3.0–4.5 cm) 52 healthy controls. addition, the effect omega-3 PUFA (n-3 PUFA) supplementation on was examined a cohort 30 as part 12 week...
Vascular diseases of the lower limb contribute substantially to global burden cardiovascular disease and comorbidities such as diabetes. Importantly, microvascular dysfunction can occur prior to, or alongside, macrovascular pathology, both potentially patient symptoms burden. Here, we describe a non-invasive approach using near-infrared spectroscopy (NIRS) during reactive hyperemia, which provides standardized assessment vascular (dys)function potential method evaluate efficacy therapeutic...
Abstract This introduction to the special issue of British Journal Aesthetics, ‘Remote Art: Engaging with Art from Distant Times and Cultures’, presents notion art’s remoteness in context debates about inter-cultural diversity. It discusses various aspects remoteness, how it figures individual contributions issue, suggests possible avenues for future scholarship.
I propose a definition of the uncanny: an anxious uncertainty about what is real caused by apparent impossibility. First, outline relevance uncanny to art and aesthetics. Second, disambiguate theoretical uses 'uncanny' establish sense term that am interested in—namely, emotional state (a kind anxiety) directed towards particular objects in world which are characteristically eerie, creepy, weird. Third, look at Edgar Allan Poe's 'The Fall House Usher' as means drawing out conditions claim...
Short-term changes in arterial stiffness with exercise are proposed to better reflect vascular impairments than resting measures alone and suggested as a prognostic indicator of cardiovascular risk older adults. Arterial indices reliable at rest, but the time-course reliability postexercise adults unknown. The precision should be determined prior their use large prospective trials. This study assessed between-day pulse wave velocity (PWV), augmentation index (AIx75) reflection magnitude (RM)...
Macrophages are implicated in the pathogenesis of abdominal aortic aneurysm (AAA). This study examined environmentally conditioned responses AAA macrophages to inflammatory stimuli. Plasma- and blood-derived monocytes were separated from whole blood patients with (30-45 mm diameter; n = 33) sex-matched control participants (n 44). Increased concentrations pro-inflammatory pro-oxidant biomarkers detected plasma patients, consistent systemic inflammation oxidative stress. However,...
Abstract Many hold that aesthetic appreciation is sensitive to the authenticity or genuineness of an object. In a recent body work, Carolyn Korsmeyer has defended claim itself property. Korsmeyer’s aim explain our objects afford sense being ‘in touch with past’. this paper, I argue cannot these objects. There no experience genuine.
Abstract Some objects we value because they afford a felt connection with people, events or places connected their past. Visiting Canterbury cathedral, you encounter the place where, in 1170, Archbishop Thomas Becket was murdered by four knights of Henry II. Knowing that are standing very where Becket's blood spilled gives past event sense tangible reality. One feels ‘in touch with’ past; history seems to ‘come alive’. In this paper, I propose an explanation for phenomenology such...
Vascular diseases of the lower limb contribute substantially to global burden cardiovascular disease and comorbidities such as diabetes. Importantly, microvascular dysfunction can occur prior to, or alongside, macrovascular pathology, both potentially patient symptoms burden. Here, we describe a non-invasive approach using near-infrared spectroscopy (NIRS) during reactive hyperemia, which provides standardized assessment vascular (dys)function potential method evaluate efficacy therapeutic...
Masculinities: Liberation through Photography PhotographyBarbican Art Gallery, 20 February–17 May 2020. Mark Windsor New College of the Humanities mark.windsor@nchlondon.ac.uk Search for other works by this author on: Oxford Academic Google Scholar The British Journal Aesthetics, Volume 60, Issue 3, July 2020, Pages 359–362, https://doi.org/10.1093/aesthj/ayaa017 Published: 06 August 2020
Anyone familiar with using a film camera will know how easy it is to talk of having taken roll photographs and the anticipation involved in waiting have them developed. In recent article, Dawn M. Wilson (2021) has argued that idea photographic images exist before development irredeemably confused. Wilson’s aim show single-stage accounts photography are untenable. According account: argues against account by arguing latent images. Concomitantly, she only viable multi-stage: The key point...