A5077945517- Fatty Acid Research and Health
- Aortic aneurysm repair treatments
- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Cardiovascular Disease and Adiposity
- Sports Performance and Training
- Birth, Development, and Health
- Lipid metabolism and biosynthesis
- Platelet Disorders and Treatments
- Diet and metabolism studies
- Exercise and Physiological Responses
- Peroxisome Proliferator-Activated Receptors
- Hemoglobin structure and function
- Erythrocyte Function and Pathophysiology
- Cardiovascular Health and Disease Prevention
- Obstructive Sleep Apnea Research
- Cardiovascular and exercise physiology
- Aortic Disease and Treatment Approaches
- Aquaculture Nutrition and Growth
- Extracellular vesicles in disease
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Eicosanoids and Hypertension Pharmacology
University of the Sunshine Coast
2017-2022
Abdominal aortic aneurysm (AAA) is associated with inflammation and oxidative stress, the latter of which contributes to activation macrophages, a prominent cell type in AAA. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported limit stress animal models The aim this study was evaluate effect n-3 PUFA docosahexaenoic acid (DHA) on antioxidant defence macrophages from patients Cells were obtained men small AAA (diameter 3.0-4.5 cm, 75 ± 6 yr, n = 19) age- matched male controls...
Markers of chronic inflammation increase with aging, and are associated cardiovascular disease prevalence mortality. Increases in fitness exercise training have been lower circulating concentrations cytokines known to pro-inflammatory actions (such as interleukin-6 [IL-6]) higher anti-inflammatory (interleukin-10 [IL-10]). However, the effect cardiorespiratory on acute cytokine responses a single bout healthy older individuals is unknown. We compared response plasma IL-6, tumor necrosis...
Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte content 43 AAA patients (diameter 3.0–4.5 cm) 52 healthy controls. addition, the effect omega-3 PUFA (n-3 PUFA) supplementation on was examined a cohort 30 as part 12 week...
Abdominal aortic aneurysm (AAA) is a vascular disease involving permanent focal dilation of the abdominal aorta (≥30 mm) that can lead to catastrophic rupture. Destructive remodeling connective tissue in AAA contributes wall stiffening, mechanical parameter arterial system linked heightened risk cardiovascular morbidity and mortality. Since stiffening associated with progression, treatment options target inflammation would appear prudent. Given this, growing evidence indicating robust...
Macrophages are implicated in the pathogenesis of abdominal aortic aneurysm (AAA). This study examined environmentally conditioned responses AAA macrophages to inflammatory stimuli. Plasma- and blood-derived monocytes were separated from whole blood patients with (30-45 mm diameter; n = 33) sex-matched control participants (n 44). Increased concentrations pro-inflammatory pro-oxidant biomarkers detected plasma patients, consistent systemic inflammation oxidative stress. However,...
Abstract Background Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range conditions including sepsis. Fresh frozen plasma (FFP) restores damaged EG to baseline thickness, however mechanism for this effect unknown, and some components FFP have adverse effects unrelated EG. There limited evidence that sphingosine-1-phosphate (S1P) within by activating cell S1P receptor 1 (S1PR ). However, there are disadvantages using clinically as an restorative therapy. A...