A5014812424- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Sodium Intake and Health
- Peripheral Artery Disease Management
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Renal and Vascular Pathologies
- Diet and metabolism studies
- Atherosclerosis and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Apelin-related biomedical research
- Venous Thromboembolism Diagnosis and Management
University of Pisa
2016-2025
Azienda Ospedaliera Universitaria Pisana
2008-2024
Ospedale Cisanello
2018-2024
Ospedale Versilia
2024
Academy of Emergency Medicine and Care
2022-2024
European Society of Hypertension
2008-2016
American Society of Echocardiography
2016
University of Florence
2016
May Institute
2016
Czech Academy of Sciences, Institute of Physiology
2016
Background —Essential hypertension is associated with impaired endothelium-dependent vasodilation. Inactivation of endothelium-derived nitric oxide by oxygen free radicals participates in endothelial dysfunction experimental hypertension. To test this hypothesis humans, we evaluated the effect antioxidant vitamin C on responses essential hypertensive patients. Methods and Results —In 14 healthy subjects (47.1±4.8 years; blood pressure, 120.6±4.5/80.9±3.5 mm Hg) patients (47.3±5.1...
Experimental data from normotensive and hypertensive animals indicate that aging is associated with impaired endothelium-dependent relaxations to acetylcholine, this possibility appears be confirmed in the human coronary artery. In present study, we evaluated effect of age on endothelial responsiveness forearm vessels either control subjects or essential patients.Within group (n = 53 n 57, respectively), were selected similar blood pressure, plasma cholesterol, glucose values,...
Endothelial dysfunction is involved in the development of atherosclerosis, which precedes asymptomatic structural vascular alterations as well clinical manifestations cardiovascular disease (CVD). function can be assessed non-invasively using flow-mediated dilation (FMD) technique. Flow-mediated represents an endothelium-dependent, largely nitric oxide (NO)-mediated dilatation conduit arteries response to imposed increase blood flow and shear stress. affected by (CV) risk factors, relates...
Age-related endothelial dysfunction could be caused by an alteration in the L-arginine-NO system and production of oxidative stress both normotensive hypertensive individuals. In 47 subjects 49 patients with essential hypertension, we evaluated forearm blood flow (by strain-gauge plethysmography) modifications induced intrabrachial sodium nitroprusside (1, 2, 4 microg/100 mL per minute) acetylcholine (0.15, 0.45, 1.5, 4.5, 15 minute), endothelium-independent vasodilator endothelium-dependent...
Background —Mental stress has been linked to increased morbidity and mortality in coronary artery disease atherosclerosis progression. Experimental studies have suggested that damage the endothelium may be an important mechanism. Methods Results —Endothelial function was studied 10 healthy men (aged 50.4±9.6 years) 8 non–insulin-dependent diabetic 52.0±7.2 years). Brachial flow-mediated dilation (FMD, dependent) response 50 μg of sublingual glyceryl trinitrate (GTN, independent) were...
To evaluate the effect of endogenous estrogens on endothelial function in humans, we examined whether menopause is associated with impairment endothelium-dependent vasodilation normotensive and essential hypertensive women. In 73 subjects (37 women, 36 men) patients (36 37 men), studied by measuring forearm blood flow modifications (strain-gauge plethysmography) induced intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, 15 micrograms/100 mL per minute), an vasodilator, sodium nitroprusside...
Background —Aging is associated with increased cardiovascular risk and endothelial dysfunction. Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related Methods Results —In 12 young elderly (age 26.9±2.3 62.9±5.8 years, respectively) healthy sedentary subjects 11 14 matched athletes 27.5±1.9 66.4±6.1 respectively), studied (with strain-gauge plethysmography) forearm blood flow modifications...
Subclinical hypothyroidism (sHT) is associated with enhanced cardiovascular risk. To test the hypothesis that patients sHT are characterized by endothelial dysfunction and impaired nitric oxide (NO) availability, in 14 [serum cholesterol, 218 +/- 41 mg/dl (5.6 0.9 mM)] 28 euthyroid subjects, subdivided into groups A B 170 19 (4.4 0.5 mM) 217 21 mM), respectively], we studied forearm blood flow (strain-gauge plethysmography) response to intrabrachial acetylcholine, an endothelium-dependent...
Sodium-glucose cotransporter-2 inhibitors reduce blood pressure (BP) and renal cardiovascular events in patients with type 2 diabetes through not fully elucidated mechanisms. Aim of this study was to investigate whether dapagliflozin is able acutely modify systemic vascular function, as well putative Neuro-hormonal variables, together 24 h diuresis, urinary sodium, glucose, isoprostanes free-water clearance were assessed before after a 2-day treatment 10 mg QD sixteen diabetic patients; data...
Flavanol consumption is favorably associated with cognitive function. We tested the hypothesis that dietary flavanols might improve function in subjects mild impairment. conducted a double-blind, parallel arm study 90 elderly individuals impairment randomized to consume once daily for 8 weeks drink containing ≈990 mg (high flavanols), ≈520 (intermediate or ≈45 (low flavanols) of cocoa per day. Cognitive was assessed by Mini Mental State Examination, Trail Making Test A and B, verbal fluency...
In vitro data support the use of combination aztreonam (ATM) with ceftazidime-avibactam (CAZ-AVI), but clinical studies are lacking. The aim our study was to compare outcome patients bloodstream infections (BSIs) due metallo-β-lactamase (MBL)-producing Enterobacterales treated either CAZ-AVI plus ATM or other active antibiotics (OAAs).This a prospective observational including admitted 3 hospitals in Italy and Greece. primary measure 30-day all-cause mortality. Secondary outcomes were...
The sympathetic nervous system (SNS) is known to play a pivotal role in short- and long-term regulation of different functions the cardiovascular system. In past decades increasing evidence demonstrated that neural control involved not only vasomotor small resistance arteries but also modulation large artery function. Sympathetic activity vascular function, both which are key factors development prognosis events disease, linked at several levels. Evidence from experimental studies indicates...
Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia few drug-induced adverse events, including large elderly cohort (median age, 81 years). An additional 48 cases mild-moderate recovered uneventfully. organotypic 3D cultures of primary human liver cells, demonstrate that interferon-α2 increases ACE2 expression infectivity parenchymal cells by...
OBJECTIVE To explore whether at-admission hyperglycemia is associated with worse outcomes in patients hospitalized for coronavirus disease 2019 (COVID-19). RESEARCH DESIGN AND METHODS Hospitalized COVID-19 (N = 271) were subdivided based on glycemic status: 1) glucose levels <7.78 mmol/L (NG) 149 [55.0%]; median 5.99 [range 5.38–6.72]), 2) known diabetes mellitus (DM) 56 [20.7%]; 9.18 [7.67–12.71]), and 3) no ≥7.78 (HG) 66 [24.3%]; 8.57 [8.18–10.47]). RESULTS Neutrophils higher...
To analyze the application of a lung ultrasound (LUS)-based diagnostic approach to patients suspected COVID-19, combining LUS likelihood COVID-19 pneumonia with patient's symptoms and clinical history.This is an international multicenter observational study in 20 US European hospitals. Patients were tested reverse transcription-polymerase chain reaction (RT-PCR) swab test had examination. We identified three phenotypes based on pre-existing chronic diseases (mixed phenotype), presence...
Abstract Background Bacterial and fungal superinfections may complicate the course of hospitalized patients with COVID-19. Objectives To identify predictors in Methods Prospective, observational study including COVID-19 consecutively admitted to University Hospital Pisa, Italy, between 4 March 30 April 2020. Clinical data outcomes were registered. Superinfection was defined as a bacterial or infection that occurred ≥48 h after hospital admission. A multivariate analysis performed factors...
To compare the effect of antihypertensive drugs on endothelium-dependent vasodilation in peripheral conduit arteries patients with essential hypertension, a prospective, randomized, parallel group study, endothelial function was assessed 168 hypertensive before and after 6-month treatment randomly assigned nifedipine GITS (30 to 60 mg, n=28), amlodipine (5 10 atenolol (50 100 n=29), nebivolol telmisartan (80 160 perindopril (2 4 n=28). If necessary, hydrochlorothiazide (25 mg) added each...
We designed the present study to evaluate whether in normotensive subjects and hypertensive patients aging causes endothelial dysfunction by a defect L-arginine–nitric oxide pathway or production of cyclooxygenase-dependent vasoconstrictors. In 43 47 essential patients, we evaluated forearm blood flow (strain-gauge plethysmography) modifications evoked intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, 15 μg/100 mL per minute), an endothelium-dependent vasodilator, presence saline, l...
Essential hypertension is characterized by impaired endothelium-dependent vasodilation. The present study was designed to investigate whether this abnormality a primary defect or consequence of blood pressure increases.In offspring essential hypertensive patients (n = 34) and normotensive subjects 30), we evaluated forearm flow (strain-gauge plethysmography) modifications induced intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, 15 micrograms.100 mL-1.min-1), an vasodilator, sodium...
Background:Essential hypertension is characterized by endothelial dysfunction, arterial stiffness, and increased oxidative stress. We evaluated the effect of short-term combined treatment with antioxidants vitamins C E on function, stress in untreated essential hypertensive patients.