A5042009011- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Cardiovascular Health and Disease Prevention
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Nitric Oxide and Endothelin Effects
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Apelin-related biomedical research
- Effects and risks of endocrine disrupting chemicals
- LGBTQ Health, Identity, and Policy
- Tracheal and airway disorders
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Regulation of Appetite and Obesity
- Birth, Development, and Health
Nuovo Ospedale San Giovanni di Dio
2020-2023
University of Pisa
2012-2020
Steno Diabetes Centers
2018-2020
University of Copenhagen
2018-2020
Gentofte Hospital
2018-2020
Azienda Usl Toscana Centro
2020
Sodium-glucose cotransporter-2 inhibitors reduce blood pressure (BP) and renal cardiovascular events in patients with type 2 diabetes through not fully elucidated mechanisms. Aim of this study was to investigate whether dapagliflozin is able acutely modify systemic vascular function, as well putative Neuro-hormonal variables, together 24 h diuresis, urinary sodium, glucose, isoprostanes free-water clearance were assessed before after a 2-day treatment 10 mg QD sixteen diabetic patients; data...
Abstract Context Mechanisms mediating the cardiovascular and renal protection exerted by SGLT2 inhibitors are still partially unknown. We investigated whether dapagliflozin modulates systemic vascular function structure, induces epigenetic modifications. Subjects Methods Forty hypertensive patients with type 2 diabetes were randomly assigned to 4-week treatment 10 mg or hydrochlorothiazide (HCT) 12.5 mg. Routine analyses; plasma renin activity; aldosterone, catecholamine, 24-hour urinary...
OBJECTIVE Sulfonylureas are first-line treatment of hepatocyte nuclear factor 1-α (HNF1A) diabetes (maturity-onset the young type 3), but many patients do not achieve optimal glycemic control without episodes hypoglycemia. We investigated combination sulfonylurea glimepiride and dipeptidyl peptidase 4 inhibitor linagliptin versus monotherapy with respect to variability, control, risk RESEARCH DESIGN AND METHODS In a randomized, double-blinded, crossover trial, HNF1A (n = 19; mean ± SD age 43...
Recent epidemiological observations have reported an association among phthalates exposure and insulin resistance, obesity, diabetes but not related to these environmental pollutants with microvascular complications of diabetes.To explore the relationship between renal function in subjects diabetes.Cross-sectional, case-only study. Concentrations three urinary metabolites di-2-ethylhexylphthalate were quantified a spot morning urine sample, normalized for creatinine excretion, clinical...
The P2X7 receptor-NLRP3 inflammasome complex (P2X7R-Infl) regulates inflammatory and immune responses. Physical exercise modulates heat-shock proteins (Hsps), influencing cytokine levels oxidative stress; Hsp72 triggers P2X7R-Infl-dependent responses.We studied the effect of a single bout maximal on lymphomonocyte expression P2X7R, NLRP3, caspase-1, NF-kB circulating IL-1β, IL-18 MCP-1, all modulated by P2X7R-Infl, in healthy sedentary (SED), trained (ATH), endurance (END) male...
To evaluate the effect of periodontitis (PD) on glucoregulatory hormones in obesity, never explored so far, a cross-sectional study was conducted 110 severely obese, non-diabetic individuals. We collected clinical periodontal parameters, including probing pocket depth (PPD), bleeding (BOP), attachment level (CAL). Insulin, glucagon, GLP-1 and GIP were measured after 3 days standardized diet. Forty-seven subjects had (PD+) 63 did not (PD−). PD+ showed 30.3% gingival sites with PPD > 4 mm,...
Objective Bariatric surgery may ameliorate renal function through vascular mechanisms. This study tested surgery’s ability to improve measured glomerular filtration rate (mGFR) and identified clinical, renal, systemic predictors of such improvement. Methods Twenty‐five nondiabetic subjects with severe obesity were studied before 1 year after Roux‐en‐Y gastric bypass, evaluating mGFR plasma flow, basal resistive index (RI) dynamic RI, visceral fat, parameters, including flow‐mediated...
Introduction Insulin regulates renal glucose production and utilization; both these fluxes are increased in type 2 diabetes (T2D). Whether insulin also controls urinary excretion is not known. Methods We applied the pancreatic clamp technique 12 healthy subjects 13 T2D subjects. Each participant received a somatostatin infusion variable to achieve (within 1 hour) maintain glycemia at 22 mmol/L for 3 hours; next, constant (240 pmol/min/kg) was added another hours. Urine collected separately...
Aims: The question asked by this study was whether β-cell function expressed insulin secretion/sensitivity measured during pregnancy in women with gestational diabetes (GDM) predicts post-partum long-term derangement glucose metabolism.
Heart failure (HF) is one of the most frequent cause hospitalization in elderly and often coexists with concurrent geriatric syndromes, like cognitive disturbances; various pathophysiological mechanisms are shared by HF decline, notably a substrate low-grade inflammation. We investigated whether SNPs purinergic receptor (P2X<sub>7</sub>R) apolipoprotein (APO) E genes, both involved series inflammatory responses, associated to or impairment able predict post-discharge mortality elderly....
Restoring euglycaemia for weeks or months improves insulin secretion in patients with type 2 diabetes (T2D). We tested whether mild decrements fasting glucose (FPG) acutely affect β-cell function and sensitivity. Thirteen normotolerant (NGT) 10 T2D volunteered pairs. In an isoglycemic test (Iso), after 100 min of stabilization, incremental infusion over 3 h was applied to raise plasma >22 mmol/l, followed by arginine challenge; a subisoglycemic (Sub), matching the time course Iso preceded...
The ß-cell dysfunction of type 2 diabetes is partly reversible. optimal time window to induce glycemic remission uncertain; short courses insulin treatment have been tested as a strategy remission. In pilot study in 38 newly-diagnosed patients, we assessed the time-course sensitivity and function (by repeat oral glucose tolerance tests) following 6-week basal compared metformin monotherapy equipoised control. At 6 weeks, secretion were increased both groups whilst was unchanged. From this...