A5051137654- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Thermoregulation and physiological responses
- Liver Disease Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Ovarian function and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver Disease and Transplantation
- Exercise and Physiological Responses
- Cardiovascular Effects of Exercise
- Nutrition and Health in Aging
- Optical Imaging and Spectroscopy Techniques
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Hydrogen's biological and therapeutic effects
- Sports Performance and Training
- Diet, Metabolism, and Disease
- Sports injuries and prevention
- Dietary Effects on Health
- Peripheral Artery Disease Management
- Genetics, Aging, and Longevity in Model Organisms
Cardiff Metropolitan University
2016-2025
University of Liverpool
2011-2025
Aintree University Hospitals NHS Foundation Trust
2025
NIHR Clinical Research Network
2024
Pennsylvania State University
2023
Kaiser Permanente Fontana Medical Center
2023
Penn State Milton S. Hershey Medical Center
2023
The University of Western Australia
2012-2017
University of Waterloo
2017
Liverpool John Moores University
2010-2015
Nonalcoholic fatty liver disease may be evident in women with polycystic ovary syndrome (PCOS), both conditions being associated obesity and insulin resistance. However, few studies have accounted for the high prevalence of PCOS. The aim this study was to determine whether PCOS is independently hepatic steatosis, compared healthy controls similar age body mass index (BMI), steatosis hyperandrogenemia. We conducted a cross-sectional, case-control at two tertiary referral centers. Twenty-nine...
Non-alcoholic fatty liver disease (NAFLD) is associated with multi-organ (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise an effective treatment for lowering fat but its effect on IR in NAFLD unknown. We aimed to determine whether supervised exercise would reduce and improve hepatic peripheral (skeletal muscle sensitivity. Sixty nine patients were randomized 16 weeks supervision (n=38) or counselling (n=31) without dietary modification. All participants underwent...
Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular (CVD). Endothelial dysfunction early manifestation of atherosclerosis and important prognostic marker future events. The aim this study was twofold: to examine 1) the association between fat, visceral adipose tissue (VAT), endothelial in obese NAFLD patients 2) impact supervised exercise training on vascular defect. Brachial artery function assessed by flow-mediated dilatation (FMD) 34 20 controls...
The objectives of our study were to examine 1) the proportion responders and nonresponders exercise training in terms vascular function; 2) a priori factors related training-induced changes conduit artery function, 3) contribution traditional cardiovascular risk exercise-induced function. We pooled data from laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type interventions with pre-/posttraining measures flow-mediated dilation (FMD%) assess All...
Episodic increases in cerebrovascular perfusion and shear stress may have beneficial impacts on endothelial function that improve brain health. We hypothesized water immersion to the level of right atrium humans would increase cerebral perfusion. continuously measured, 9 young (means ± SD, 24.6 2.0 yr) healthy men, systemic hemodynamic variables along with blood flows common carotid middle posterior arteries during controlled filling emptying a tank atrium. Mean arterial pressure (80 vs. 91...
Although physical activity (PA) is crucial in the prevention and clinical management of nonalcoholic fatty liver disease, most individuals with this chronic disease are inactive do not achieve recommended amounts PA. There a robust consistent body evidence highlighting benefit participating regular PA, including reduction fat improvement composition, cardiorespiratory fitness, vascular biology, health-related quality life. Importantly, benefits PA can be seen without clinically significant...
Abstract Background and Aims Exercise is recommended for the management of metabolic dysfunction‐associated steatotic liver disease (MASLD), yet effects on histology remain unknown, especially without significant weight loss. We aimed to examine changes in surrogate measures histological response with exercise training. Methods conducted a post hoc pooled analysis three randomised controlled trials (duration: 12–20 weeks) comparing aerobic interventions controls. The primary outcome measure...
The leading causes of mortality in nonalcoholic fatty liver disease (NAFLD) relate to cardiovascular (CVD). contribution nitric oxide (NO) endothelial function, a surrogate CVD risk, is currently unknown NAFLD. We hypothesize that NO-mediated cutaneous microvessel function would be impaired NAFLD compared with controls and exercise enhance conventional care. Thirteen patients (aged 50 ± 3 yr, BMI 31 1 kg/m 2 ) seven (48 4 30 were studied. randomized either 16 wk or Cutaneous was examined...
The aim of this study was to examine the contribution arterial shear changes in flow-mediated dilation (FMD) during sympathetic nervous system (SNS) activation healthy humans. Ten men reported our laboratory four times. Bilateral FMD, rate (SR), and catecholamines were examined before/after 10-min -35-mmHg lower body negative pressure (LBNP10). On day 1, localized forearm heating (LBNP10+heat) applied one limb abolish increase retrograde SR associated with LBNP. Day 2 involved unilateral...
Introduction: Regular exercise induces recurrent increases in cerebrovascular perfusion. In peripheral arteries, such episodic perfusion are responsible for improvement arterial function and health. We examined the hypothesis that during immersion augments cerebral blood flow velocity compared with intensity-matched land-based exercise. Methods: Fifteen normotensive participants were recruited (26 ± 4 yr, 24.3 1.9 kg·m-2). continuously assessed mean pressure, HR, stroke volume, oxygen...
Polycystic ovary syndrome (PCOS) is associated with cardiovascular disease. The contribution of the nitric oxide (NO) dilator system to cutaneous endothelial dysfunction currently unknown in PCOS. Our aim was examine whether women PCOS demonstrate impaired microvascular NO function and exercise training can ameliorate any impairment. Eleven (age, 29 ± 7 years; body mass index, 34 6 kg m(-2)) were compared six healthy obese control 5 m(-2)). Six (30 31 then completed 16 weeks training. Laser...
Abstract The May Measurement Month (MMM) campaign was carried out in the Republic of Ireland (RoI) and United Kingdom (UK) 2022 with aim raising awareness raised blood pressure (BP). Here, we report on findings campaign. Adults aged ≥ 18 years were recruited opportunistically at hospitals, general practice surgeries, community pharmacies, universities, gyms, various other public places. Three seated BP readings taken each participant, along completion a questionnaire demographics, lifestyle...
Polycystic ovarian syndrome (PCOS) is associated with an adverse cardiovascular disease (CVD) profile. A surrogate marker for CVD risk endothelial dysfunction. Limited studies exist examining the and metabolic effects of exercise in PCOS specifically its impact on function. Therefore, aim current study was to investigate function, parallel body composition, insulin resistance, cardiopulmonary fitness PCOS.Ten women (27 yr, 95% confidence interval [CI] = 23-32; 31 kg·m⁻², CI 28-34) completed...
PCOS (polycystic ovary syndrome) is associated with IR (insulin resistance), increased visceral fat and NAFLD (non-alcoholic fatty liver disease) all of which may contribute to endothelial dysfunction, an early marker CVD (cardiovascular risk. Our objective was examine the relationships between dysfunction in PCOS, volume AT (adipose tissue) compartments size intracellular TAG (triacylglycerol) pools skeletal muscle. A total 19 women (means±S.D.; 26±6 years, 36±5 kg/m2) 16 control (31±8 30±6...
Purpose We performed two experiments to determine whether cutaneous microvascular adaptations in response repeated core temperature (Tc) elevation are mediated by increases skin blood flow (SkBF) and/or temperature. Methods Healthy subjects participated for 8 wk thrice-weekly bouts of 30-min lower limb heating (40°C). In study 1, both forearms were "clamped" at basal throughout each bout (n = 9). Study 2 involved identical heating, with the under ambient conditions (unclamped, n 10)....
Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are used for treatment in type 2 diabetes mellitus (T2DM). Little is known about their cardiovascular (CV) impact. We sought to determine the effects of chronic on vascular function T2DM. Brachial artery endothelial-dependent flow-mediated dilation (FMD) and endothelial-independent glyceryl trinitrate (GTN) carotid intima-medial thickness (cIMT) were assessed 11 severely obese T2DMs (4 females, 7 males: 55 ± 8 years, duration 8.3 4.7 years...