A5079642827- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Organ Transplantation Techniques and Outcomes
- Frailty in Older Adults
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Clinical Nutrition and Gastroenterology
- Pancreatic and Hepatic Oncology Research
- Liver Diseases and Immunity
- Renal Transplantation Outcomes and Treatments
- Cardiovascular and exercise physiology
- Diet, Metabolism, and Disease
- Neuroendocrine Tumor Research Advances
- Drug-Induced Hepatotoxicity and Protection
- Dialysis and Renal Disease Management
- Body Composition Measurement Techniques
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Hip and Femur Fractures
Northwestern University
2022-2025
Northwestern Medicine
2022-2025
University of Pittsburgh
2019-2024
University of Arkansas for Medical Sciences
2014-2024
University of Pittsburgh Medical Center
2019-2024
VA Connecticut Healthcare System
2024
Loma Linda University
2024
Yale University
2024
Northwestern University
2023
Pennsylvania State University
2023
<h3>Context</h3>Chronic hepatitis C virus (HCV) infection outcomes include liver failure, hepatocellular carcinoma (HCC), and liver-related death.<h3>Objective</h3>To assess the association between sustained virological response (SVR) all-cause mortality in patients with chronic HCV advanced hepatic fibrosis.<h3>Design, Setting, Patients</h3>An international, multicenter, long-term follow-up study from 5 large tertiary care hospitals Europe Canada of 530 who started an interferon-based...
Failure of liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) and unreliable results occur in ≈ 5% 15% patients, respectively, mainly due to obesity. In this multicenter study, we evaluated the feasibility performance novel FibroScan XL probe 276 patients with chronic disease (42% viral hepatitis, 46% nonalcoholic fatty [NAFLD]) a body mass index (BMI) ≥ 28 kg/m(2) . Patients underwent biopsy TE standard M probes. failure was defined as no valid LSMs examinations <10...
Abstract Background Accurate tools for the noninvasive detection of hepatic steatosis are needed. The Controlled Attenuation Parameter ( CAP ) specifically targets liver using a process based on transient elastography. Methods Patients with chronic disease and body mass index BMI ≥28 kg/m 2 underwent biopsy stiffness measurement LSM simultaneous determination FibroScan ® M probe. performance diagnosing compared was assessed areas under receiver operating characteristic curves AUROC )....
Limitations of the Model for End-Stage Liver Disease (MELD) score include its failure to assess nutritional and functional status cirrhotic patients. Our objectives were evaluate impact sarcopenia in cirrhosis whether inclusion muscularity assessment within MELD could improve prediction mortality patients with cirrhosis.We included 669 who consecutively evaluated liver transplantation. Skeletal muscle index at third lumbar vertebra (L3 SMI) was measured by computed tomography, defined using...
Frailty has emerged as a powerful predictor of outcomes in patients with cirrhosis and inevitably made its way into decision making within liver transplantation. In an effort to harmonize integration the concept frailty among transplant centers, AST ASTS supported efforts our working group develop this statement from experts field. is multidimensional construct that represents end-manifestation derangements multiple physiologic systems leading decreased reserve increased vulnerability health...
Loss of muscle mass and function, or sarcopenia, is a common feature cirrhosis contributes significantly to morbidity mortality in this population. Sarcopenia main indicator adverse outcomes population, including poor quality life, hepatic decompensation, patients with evaluated for liver transplantation (LT), longer hospital intensive care unit stay, higher incidence infection following LT, overall health cost. Although it clear that an important predictor LT outcomes, many questions...
A consensus conference on frailty in kidney, liver, heart, and lung transplantation sponsored by the American Society of Transplantation (AST) endorsed Nephrology (ASN), Transplant Surgeons (ASTS), Canadian (CST) took place February 11, 2018 Phoenix, Arizona. Input from transplant community through scheduled calls enabled wide discussion current concepts frailty, exploration best practices for risk assessment candidates management after transplant, development ideas future research....
Sarcopenia and physical deconditioning are frequent complications in patients with cirrhosis end‐stage liver disease (ESLD). They the end result of impaired dietary intake, chronic inflammation, altered macronutrient micronutrient metabolism, low activity. Frailty is prolonged sarcopenia deconditioning. It severely affects a patient's functional status presents approximately 1 5 on transplantation waiting list. Sarcopenia, poor fitness/cardiopulmonary endurance (CPE), frailty all associated...
Sterling, Richard K.; Duarte-Rojo, Andres; Patel, Keyur; Asrani, Sumeet Alsawas, Mouaz; Dranoff, Jonathan A.; Fiel, Maria Isabel; Murad, M. Hassan; Leung, Daniel H.; Levine, Deborah; Taddei, Tamar Taouli, Bachir; Rockey, Don C. Author Information
Sterling, Richard K.; Patel, Keyur; Duarte-Rojo, Andres; Asrani, Sumeet Alsawas, Mouaz; Dranoff, Jonathan A.; Fiel, Maria Isabel; Murad, M. Hassan; Leung, Daniel H.; Levine, Deborah; Taddei, Tamar Taouli, Bachir; Rockey, Don C. Author Information
Objectives: Diagnosing minimal hepatic encephalopathy (MHE) is challenging, and point-of-care tests are needed. Stroop EncephalApp has been validated for MHE diagnosis in single-center studies. The objective of the study was to validate a multicenter study. Methods: Outpatient cirrhotics (with/without prior overt (OHE)) controls from three sites (Virginia (VA), Ohio (OH), Arkansas (AR)) underwent two gold standards, psychometric score (PHES) inhibitory control test (ICT)....
OBJECTIVES: Exercise has been scarcely studied in patients with cirrhosis, and prior evidence showed hepatic venous pressure gradient (HVPG) to be increased response exercise. The aim of this study was investigate the effects a supervised physical exercise program (PEP) cirrhosis. METHODS: In an open-label, pilot clinical trial, cirrhosis were randomized PEP (cycloergometry/kinesiotherapy plus nutritional therapy,n=14) or control (nutritional therapy,n=15); for 14 weeks. Primary outcomes...
Severe alcoholic hepatitis (sAH) is associated with a poor prognosis. There no proven effective treatment for sAH, which why early transplantation has been increasingly discussed. Hepatoblastoma-derived C3A cells express anti-inflammatory proteins and growth factors were tested in an extracorporeal cellular therapy (ELAD) study to establish their effect on survival subjects sAH. Adults bilirubin ≥8 mg/dL, Maddrey's discriminant function ≥ 32, Model End-Stage Liver Disease (MELD) score ≤ 35...
Liver disease and portal hypertension can be associated with pulmonary vascular complications, including portopulmonary (POPH), characterised by an elevated mean artery pressure secondary to increased resistance, hepatopulmonary syndrome (HPS), hypoxaemia due vasodilatation shunting. Although clear diagnostic guidelines exist for both conditions on the basis of echocardiography, right heart catheterisation arterial blood gases, there is considerable variation between centres regarding...
Management of hepatic encephalopathy (HE) remains challenging from a medical and psychosocial perspective. Members the International Society for Hepatic Encephalopathy Nitrogen Metabolism recognized 5 key unresolved questions in HE management focused on (i) driving, (ii) ammonia levels clinical practice, (iii) testing strategies covert or minimal HE, (iv) therapeutic options, (v) nutrition patient-reported outcomes. The consensus document addresses these topical issues with succinct review...