A5030372642- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Iron Metabolism and Disorders
- Liver Diseases and Immunity
- Vaccine Coverage and Hesitancy
- Endoplasmic Reticulum Stress and Disease
- Hepatitis Viruses Studies and Epidemiology
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Screening and Detection
- Inflammasome and immune disorders
- Global Cancer Incidence and Screening
- Healthcare professionals’ stress and burnout
- Global Health Care Issues
- Cholesterol and Lipid Metabolism
University of Washington
2016-2025
VA Puget Sound Health Care System
2016-2025
University of Puget Sound
2011-2024
Health Services Research & Development
2013-2024
Durham VA Health Care System
2024
National and Kapodistrian University of Athens
2024
Seattle University
2002-2024
Fred Hutch Cancer Center
2022-2023
University of Washington Medical Center
2002-2022
University Gastroenterology
2017-2022
MicroRNAs miR-122, miR-34a, miR-16 and miR-21 are commonly deregulated in liver fibrosis hepatocellular carcinoma. This study examined whether circulating levels of these miRNAs correlate with hepatic histological disease severity patients chronic hepatitis C infection (CHC) or non-alcoholic fatty-liver (NAFLD) can potentially serve as markers for stage assessment. We first used an vitro model virus (HCV) to measure the extracellular four miRNAs. Whereas were unchanged, miR-34a a lesser...
<h3>Importance</h3> Identifying independent risk factors for adverse outcomes in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can support prognostication, resource utilization, and treatment. <h3>Objective</h3> To identify excess associated hospitalization, mechanical ventilation, mortality SARS-CoV-2 infection. <h3>Design, Setting, Participants</h3> This longitudinal cohort study included 88 747 tested nucleic acid by polymerase chain reaction between...
Abstract The majority of patients with nonalcoholic fatty liver disease (NAFLD) have “simple steatosis,” which is defined by hepatic steatosis in the absence substantial inflammation or fibrosis and considered to be benign. However, 10%-30% NAFLD progress fibrosing steatohepatitis (NASH), characterized varying degrees fibrosis, addition steatosis, can lead cirrhosis. cause(s) progression are unclear. We aimed test relative contributions dietary fat cholesterol their interaction on...
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced disease. Mechanisms that underlie this progression remain poorly understood, partly due lack good animal models resemble human NASH. We previously showed several syndrome features develop in LDL receptor-deficient (LDLR-/-) mice fed a diabetogenic diet are worsened by dietary cholesterol. To test whether cholesterol alter phenotype we LDLR-/-...
We sought to determine whether hepatic cholesterol crystals are present in patients or mice with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH), and their presence distribution correlates the of NASH as compared simple steatosis. identified, by filipin staining, free within hepatocyte lipid droplets C57BL/6J that developed following a high-fat high-cholesterol diet. Under polarized light these exhibited strong birefringence suggesting some was form crystals. Activated...
The underlining mechanisms of dietary cholesterol and nonalcoholic steatohepatitis (NASH) in contributing to hepatocellular carcinoma (HCC) remain undefined. Here we demonstrated that high-fat-non-cholesterol-fed mice developed simple steatosis, whilst high-fat-high-cholesterol-fed NASH. Moreover, induced larger more numerous NASH-HCCs than non-cholesterol-induced steatosis-HCCs diethylnitrosamine-treated mice. displayed significantly aberrant gene expression-enriched signaling pathways...
Information about the effectiveness of oral antivirals in preventing short- and long-term COVID-19-related outcomes setting Omicron variant transmission COVID-19 vaccination is limited.
The presence of elevated serum aminotransferase activity is a sign possible underlying liver disease. We aimed to describe the prevalence and associations in recent, nationally representative U.S. survey.We described predictors alanine (ALT >43 IU/L) or aspartate (AST >40 among 6,823 participants National Health Nutrition Examination Survey (NHANES) conducted between 1999 2002. compared our findings results already published based on NHANES 1988 1994.In 1999-2002, prevalences ALT, AST,...
Our aim was to identify predictors of colorectal cancer screening in the United States and subgroups with particularly low rates screening.The responses a telephone-administered questionnaire nationally representative sample 61,068 persons aged >/=50 yr were analyzed. Current defined as either sigmoidoscopy/colonoscopy preceding 5 years or fecal occult blood testing (FOBT) year, both.Overall, current reported by 43.4% (sigmoidoscopy/colonoscopy 22.8%, FOBT 9.9%, both 10.7%). The lowest...
Gestational diabetes and pregnancy-induced hypertension are common, their relation is not well understood. The authors conducted a population-based case-control study using 1992-1998 Washington State birth certificate hospital discharge records to investigate this relation. Consecutive cases of were divided into four groups based on International Classification Diseases, Ninth Revision codes: eclampsia (n=154), severe preeclampsia (n=1,180), mild (n=5,468), gestational (n=8,943). Cases...