A5032915645- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Clinical Nutrition and Gastroenterology
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Transplantation: Methods and Outcomes
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Oral health in cancer treatment
- Mesenchymal stem cell research
Fred Hutch Cancer Center
2013-2024
University of Washington
2012-2024
Cancer Research Center
1994-2022
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
1998-2022
University of Newcastle Australia
2019
John Hunter Hospital
2019
Seattle University
1980-2018
Cancer Research Institute
2013
University of Washington Medical Center
1980-2011
International Society for Heart and Lung Transplantation
2011
The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity chronic graft-versus-host disease (GVHD). 2014 NIH consensus maintains framework prior with further refinement based on evidence. Revisions have been made to address areas controversy or confusion, such as overlap GVHD subcategory distinction between active past tissue damage. Diagnostic involvement mouth, eyes, genitalia, lungs revised. Categories should be defined...
This consensus document is intended to serve 3 functions. First, it standardizes the criteria for diagnosis of chronic graft-versus-host disease (GVHD). Second, proposes a new clinical scoring system (0-3) that describes extent and severity GVHD each organ or site at any given time, taking functional impact into account. Third, guidelines global assessment are based on number organs sites involved degree involvement in affected (mild, moderate, severe). Diagnosis requires presence least 1...
Over the past decade, advances have been made in care of patients undergoing transplantation. We conducted a study to determine whether these improved outcomes transplantation.We analyzed overall mortality, mortality not preceded by relapse, recurrent malignant conditions, and frequency severity major complications transplantation, including graft-versus-host disease (GVHD) hepatic, renal, pulmonary, infectious complications, among 1418 who received their first allogeneic transplants at our...
Objective: To determine the incidence and clinical course of veno-occlusive disease liver (VOD) after bone marrow transplantation to analyze risk factors for severe VOD. Design: Cohort study 355 consecutive patients. Setting: A center. Measurements: Each patient was prospectively evaluated VOD, many VOD were analyzed using logistic regression models. The relation renal cardiopulmonary failure time-dependent proportional hazards Results: Veno-occlusive developed in 190 patients (54%; 95% CI,...
Venocclusive disease (VOD) of the liver, a fibrous obliteration small hepatic venules, can be caused by chemoradiation therapy. We reviewed 255 consecutive patients undergoing bone marrow transplantation for malignancy during 1978 to 1980 in order determine incidence VOD and predisposing factors. Fifty-three met our criteria VOD, an 21%. Multivariate analysis showed that most significant risk factors were age over 15, underlying other than acute lymphocytic leukemia hepatitis prior...
The lack of standardized criteria for quantitative measurement therapeutic response in clinical trials poses a major obstacle the development new agents chronic graft-versus-host disease (GVHD). This consensus document was developed to address several objectives be used GVHD-related trials. proposed measures should practical use both by transplantation and nontransplantation medical providers, adaptable adults children, focused on most important GVHD manifestations. also give preference...
This consensus document provides an update for pathologists and clinicians about the interpretation of biopsy results use this information in management hematopoietic cell transplantation patients. Optimal sampling tissue preparation are discussed. Minimal criteria diagnosis graft-versus-host disease (GVHD) proposed, together with specific requirements chronic GVHD. Four final diagnostic categories (no GVHD, possible consistent definite GVHD) reflect integration histopathology clinical,...
Allogeneic hematopoietic cell transplantation is indicated for refractory hematologic cancer and some nonmalignant disorders. Survival limited by recurrent organ toxicity.To determine whether survival has improved over the past decade note impediments to better outcomes.The authors compared cohorts that had transplants during 2003 2007 versus 2013 2017. outcome measures were analyzed, along with transplant-related complications.A center performing allogeneic transplant procedures.All...
The 2006 National Institutes of Health (NIH) Consensus paper presented recommendations by the Ancillary Therapy and Supportive Care Working Group to support clinical research trials in chronic graft-versus-host disease (GVHD). Topics covered that inaugural effort included prevention management infections common complications GVHD, as well for patient education appropriate follow-up. Given new literature has emerged during past 8 years, we made further organ-specific refinements these...
We evaluated the relationship between signs and symptoms of clinical syndrome called veno-occlusive disease liver after bone marrow transplantation histological findings in 76 patients who later came to autopsy. Coded necropsy was scored for individual features that were correlated with prospectively assessed had exhibited during life. Patients stratified into two groups: those severe (n = 32) without. Clinically statistically several zone 3 acinar changes: occluded hepatic venules,...
Evaluation of the diagnostic utility rectal biopsy in graft-versus-host disease (GVHD), using crypt abscess as a major criterion, was based on 52 patients who had received marrow allografts for leukemia or aplastic anemia. Thirty-six these acute GVHD by skin criteria. These 36 demonstrated strong association with severity clinical GVHD. High stool volume also correlated strongly abscess. Patients without clear evidence usually normal histology. Serial studies showed good correlation results...
Therapeutic options for severe hepatic veno-occlusive disease (VOD) are limited and outcomes dismal, but early phase I/II studies have suggested promising activity acceptable toxicity using the novel polydisperse oligonucleotide defibrotide. This randomized II dose-finding trial determined efficacy of defibrotide in patients with VOD following hematopoietic stem cell transplantation (HSCT) identified an appropriate dose future trials. Adult pediatric received either lower-dose (arm A: 25...