A5002048183- Hematopoietic Stem Cell Transplantation
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Cystic Fibrosis Research Advances
- Acute Myeloid Leukemia Research
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Respiratory viral infections research
- Sirtuins and Resveratrol in Medicine
- Curcumin's Biomedical Applications
- Mycobacterium research and diagnosis
- Corneal Surgery and Treatments
- Neurogenetic and Muscular Disorders Research
- Hemoglobinopathies and Related Disorders
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
Fred Hutch Cancer Center
2015-2025
University of Washington
2013-2025
University of Washington Medical Center
2019
Cancer Research Center
2017
Bristol-Myers Squibb (Germany)
2017
Mayo Clinic in Florida
2017
Gilead Sciences (United States)
2017
Incyte (United States)
2017
Pfizer (United Kingdom)
2017
Janssen (France)
2017
The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity chronic graft-versus-host disease (GVHD). 2014 NIH consensus maintains framework prior with further refinement based on evidence. Revisions have been made to address areas controversy or confusion, such as overlap GVHD subcategory distinction between active past tissue damage. Diagnostic involvement mouth, eyes, genitalia, lungs revised. Categories should be defined...
Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (HCT) is associated with high mortality. We hypothesized that inhaled fluticasone, azithromycin, and montelukast (FAM) a brief steroid pulse could avert progression of new-onset BOS. tested this in phase II, single-arm, open-label, multicenter study (NCT01307462). Thirty-six patients were enrolled within 6 months BOS diagnosis. The primary endpoint was treatment failure, defined as 10% or greater...
Recognition of the earliest signs and symptoms chronic graft-versus-host disease (GVHD) that lead to severe manifestations remains a challenge. The standardization provided by National Institutes Health (NIH) 2005 2014 consensus projects has helped improve diagnostic accuracy severity scoring for clinical trials, but utilization these tools in routine practice is variable. Additionally, when patients meet NIH criteria, many already have significant morbidity possibly irreversible organ...
Section:ChooseTop of pageAbstract <<OverviewIntroductionWorkshop Format and Metho...Defining ICHPICH PopulationsConsensus DefinitionDefining Diagnostic Crite...Current Approa...ConclusionsReferences
The natural history of lung function in patients with bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplant is poorly characterized. Understanding the trajectory necessary for prompt clinical recognition and treatment also rational design prospective studies.To describe longitudinal parameters, including FEV1, BOS transplant.Subjects defined by National Institutes Health consensus guidelines criteria from a recent multicenter trial combination fluticasone,...
Abstract Background Hematopoietic-cell transplant (HCT) recipients are at risk for severe respiratory syncytial virus (RSV) infection. We evaluated the RSV fusion inhibitor presatovir in a randomized, double-blind, Phase II trial HCT with upper tract infections. Methods Patients were stratified by lymphopenia (&lt;200/µL) and ribavirin use; (&lt;200/μL) use, to receive oral 200 mg or placebo on Days 1, 5, 9, 13, 17, followed through Day 28. The coprimary efficacy endpoints...
We examined the formation, participation, and functional specialization of virus-reactive Foxp3(+) regulatory T cells (Tregs) in a mouse model influenza virus infection. "Natural" Tregs generated intrathymically, based on interactions with self-peptide, proliferated response to homologous viral Ag lungs and, lesser extent, lung-draining mediastinal lymph nodes (medLNs) virus-infected mice. In contrast, conventional CD4(+) identical TCR specificity underwent little or no conversion become...
Purpose To compare the risks of serious health outcomes among hematopoietic cell transplantation (HCT) survivors versus a matched population patients with cancer who did not undergo HCT, where primary difference may be exposure to HCT. Methods Two-year HCT treated at comprehensive center from 1992 through 2009 were Washington State residents (n = 1,792; 52% allogeneic and 90% hematologic malignancies) frequency by demographic characteristics underlying diagnosis (as applicable) non-HCT...
Approximately 2,500 pediatric hematopoietic cell transplants (HCTs), most of which are allogeneic, performed annually in the United States for life-threatening malignant and nonmalignant conditions. Although HCT is undertaken with curative intent, post-HCT complications limit successful outcomes, pulmonary dysfunction representing leading cause nonrelapse mortality. To better understand, predict, prevent, and/or treat after HCT, a multidisciplinary group 33 experts met 2-day National...
Other than lung transplantation (LT), no specific therapies exist for end-stage disease resulting from hematopoietic stem cell (HCT)-related complications, such as bronchiolitis obliterans syndrome (BOS). We report the indications and outcomes in patients who underwent LT after HCT hematologic a retrospective case series at our institution review of medical literature. identified total 70 cases HCT, including 9 allogeneic recipients between 1990 2010. In cohort, median age was 16 years...
Early detection of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (HCT) depends on recognition subclinical spirometric changes, which is possible only with frequent interval spirometry. We evaluated the feasibility home monitoring weekly spirometry via a wireless handheld device and web portal in cohort high-risk patients for lung function changes preceding BOS diagnosis. In this observational study, 46 chronic graft-versus-host disease or decline...
Abstract Background Limited data exist on the association between specific symptoms and viral loads of common cold coronavirus (ccCOV). We investigated this potential in allogeneic hematopoietic cell transplant (HCT) recipients.Figure 1.Proportion sampling time points with each symptom Methods Four hundred seventy-one children adults were prospectively followed weekly questionnaires through one year after HCT at Fred Hutchinson Cancer Center (12/2005-2/2010). Multiplex PCR for 11 respiratory...
Parametric response mapping (PRM) is a novel computed tomography (CT) technology that has shown potential for assessment of bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HCT). The primary aim this study was to evaluate whether variations in image acquisition under real-world conditions affect the PRM measurements clinically diagnosed BOS. CT scans were obtained retrospectively from 72 HCT recipients with BOS and graft-versus-host disease Fred...
Highlights•Frequent lung function monitoring after hematopoietic cell transplantation is expensive and inconvenient•Forced expiratory volume in 1 second from a portable handheld device correlated agreed with laboratory forced second•Handheld spirometers can be used to screen for decline transplantationAbstractEarly detection of subclinical may help identify allogeneic transplant (HCT) recipients who are at increased risk late noninfectious pulmonary complications, including bronchiolitis...
Influenza infection in humans evokes a potent CD8+ T-cell response, which is important for clearance of the virus but may also exacerbate pulmonary pathology. We have previously shown mice that expression TNF-α required severe and lethal lung injury following recognition an influenza antigen expressed by alveolar epithelial cells. Since first as transmembrane protein then proteolytically processed to release soluble form, we sought characterize role processing T-cell-mediated injury. In this...
Historically, diagnosis of enigmatic pulmonary disease after hematopoietic cell transplantation (HCT) required lung biopsy, but recent advancements in and therapy for respiratory infections have changed how clinicians approach abnormalities. We examined temporal trends the use biopsy HCT. retrospectively reviewed patients who underwent their first allogeneic HCT at Fred Hutchinson Cancer Research Center between years 1993 to 1997, 2003 2007, 2013 2015 subsequently surgical any reason. Lung...
Drugs that can rapidly inhibit respiratory infection from influenza or other pathogens are needed. One approach is to engage primary innate immune defenses against viral infection, such as activating the IFN pathway. In this study, we report a small, cell-permeable compound called 5,6-di-methylxanthenone-4-acetic acid (DMXAA) induce protection vesicular stomatitis virus in vitro and H1N1 A vivo through activation. Using mouse C10 bronchial epithelial cell line cultures of nasal cells,...