A5016042733- Cystic Fibrosis Research Advances
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- Tannin, Tannase and Anticancer Activities
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Biotin and Related Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Nematode management and characterization studies
Icahn School of Medicine at Mount Sinai
2022-2025
Stanford University
2016-2022
Harvard University
2021
Abstract Immune suppression heightens the risk for fungal infections, but mechanisms that result in clinical disease are poorly understood. Here we demonstrate macrophage ferroptosis, an iron-dependent form of regulated cell death, inhibits Aspergillus fumigatus ( Af ) killing. In a mouse tracheal transplant model infection, observed increase lipid peroxidation, decreased expression negative ferroptosis regulators Gpx4 and Slc7a11 , positive Ptgs2 Nox2 relative to syntransplants. Depletion...
Purpose NCIC Clinical Trials Group PA.3 was a randomized control trial that demonstrated improved overall survival (OS) in patients receiving erlotinib addition to gemcitabine for locally advanced or metastatic pancreatic cancer. Prior therapy, had plasma samples drawn future study. We sought identify biomarkers within these samples. Experimental Design Using the proximity ligation assay (PLA), probe panel built from commercially available antibodies 35 key proteins selected global genetic...
Cystic fibrosis (CF) lung transplant recipients (LTRs) exhibit a disproportionately high rate of life-threatening invasive aspergillosis (IA). Loss the cystic transmembrane conductance regulator (CFTR-/-) in macrophages (mφs) has been associated with lyosomal alkalinization. We hypothesize that this alkalinization would persist iron-laden post-transplant microenvironment increasing risk IA. To investigate our hypothesis, we developed murine CF orthotopic tracheal (OTT) model. Iron levels...
Abstract Background: Hormone receptor-positive (HR+) breast cancer (BC) is a disease of late recurrence. HR+ BC patients who are free after five years adjuvant hormonal therapy, have an ongoing risk recurrence and death for at least 15 from diagnosis. Multiple trials demonstrated consistent absolute benefits with extending endocrine therapy to 10 in patients. In several extended trials, we shown that BCI(HoxB13/IL17BR) [BCI(H/I)]-high biomarker expression benefit while those low BCI(H/I)-low...