A5055233483- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Polyomavirus and related diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Tracheal and airway disorders
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Antifungal resistance and susceptibility
- Respiratory Support and Mechanisms
- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Hepatitis C virus research
- Atrial Fibrillation Management and Outcomes
- Medical Imaging and Pathology Studies
- Cardiac Arrhythmias and Treatments
- Infections and bacterial resistance
- Sarcoidosis and Beryllium Toxicity Research
- Dysphagia Assessment and Management
- Peptidase Inhibition and Analysis
- Herpesvirus Infections and Treatments
Stanford University
2016-2025
Queen's University
2025
University of California, San Francisco
2025
Newcastle University
2024
Stanford Medicine
2011-2023
University of Oxford
2023
Stanford Health Care
2009-2022
Palo Alto University
2013-2022
British Heart Foundation
2017-2018
Pulmonary and Critical Care Associates
2016
Pulmonary arterial hypertension (PAH) is an incurable disease associated with viral infections and connective tissue diseases. The relationship between inflammation pathogenesis in these disorders remains poorly understood. To determine whether immune dysregulation due to absent T-cell populations directly contributes the development of PAH. Vascular endothelial growth factor receptor 2 (VEGFR2) blockade induced significant pulmonary apoptosis T-cell-deficient rats but not...
Pulmonary hypertension (PH) is a serious condition that affects mainly young and middle-aged women, its etiology poorly understood. A prominent pathological feature of PH accumulation macrophages near the arterioles lung. In both clinical tissue SU5416 (SU)/athymic rat model severe PH, we found accumulated expressed high levels leukotriene A4 hydrolase (LTA4H), biosynthetic enzyme for B4 (LTB4). Moreover, macrophage-derived LTB4 directly induced apoptosis in pulmonary artery endothelial...
Lymphedema is a common debilitating condition with very limited treatment options, and leukotriene B 4 may be key pathogenic molecule therapeutic target.
Respiratory syncytial virus (RSV) infection in lung transplant recipients is associated with high morbidity. This study evaluated the RSV fusion inhibitor presatovir RSV-infected recipients.
Implemented in 2005, the lung allocation score (LAS) aims to distribute donor organs based on overall survival benefits for all potential recipients, rather than waiting list time accrued. While prior work has shown that patients with scores greater 46 are at increased risk of death, it is not known whether equivalent among such when stratified by LAS and diagnosis. We retrospectively evaluated 5331 adult transplant recipients from May 2005 February 2009 determine association (groups < or...
In 2005, the lung allocation score (LAS) was implemented to prioritize organ minimize waiting-list mortality and maximize 1-year survival. It resulted in transplantation of older sicker patients without changing Its effect on resource use is unknown.To determine changes over time transplant admissions.Solid recipients were identified within Nationwide Inpatient Sample (NIS) data from 2000 2011. Joinpoint regression methodology performed identify a point change mean total hospital charges...
Implementation of the lung allocation score (LAS) in 2005 led to transplantation older and sicker patients without altering 1-year survival. However, long-term survival has not been assessed emphasizing metric may actually sustain while reflecting worsening longer-term Therefore, we overall conditional survival; effect crossing threshold on hazard death three temporal cohorts: historical (1995-2000), pre-LAS (2001-2005) post-LAS (2005-2010). One-year remained similar (83.1% vs. 82.1%) better...
Donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) are associated with worse outcomes after lung transplantation. To determine the incidence and characteristics of DSA early transplantation, we conducted a prospective multicenter observational study that used standardized treatment testing protocols. Among 119 transplant recipients, 43 (36%) developed DSA: 6 (14%) only class I HLA, 23 (53%) II 14 (33%) both HLA. The median mean fluorescence intensity (MFI) was 3197....
Respiratory syncytial virus (RSV) and parainfluenza (PIV) can cause significant morbidity mortality in lung heart-lung transplant recipients. We evaluated the utility of a multi-drug protocol for treatment RSV- PIV-related infections.RSV or PIV was identified 25 patients with total 29 infectious episodes between January 2006 December 2007. The study included 20 women 5 men, mean age 42 +/- 13 years. Fifteen had received bilateral remainder either single transplant. Mean time from to...
Chronic rejection, manifested pathologically as airway fibrosis, is the major problem limiting long-term survival in lung transplant recipients. Airway hypoxia and ischemia, resulting from a failure to restore bronchial artery (BA) circulation at time of transplantation, may predispose patients chronic rejection. To address this possibility, clinical information needed describing status perfusion oxygenation after transplantation.To determine relative pulmonary arterial blood flow, tissue BA...
Abstract Purpose Non‐tuberculous mycobacteria ( NTM ) are important pathogens in lung transplant recipients. This study describes the spectrum of respiratory tract infections and examines association with complications. Methods Data from 208 recipients transplanted November 1990 to 2005 were analyzed. Follow‐up data available 2010. Lung infection was defined by bronchoalveolar lavage, sputum, or blood cultures appropriate clinical setting. All identified tabulated. The cohort patients +)...
Although controlled donation after circulatory determination of death (cDCDD) could increase the supply donor lungs within United States, yield from cDCDD donors remains low compared with neurologic (DNDD). To explore reason for lung donors, Scientific Registry Transplant Recipient data were used to assess impact quality on utilization by fitting a logistic regression model. The relationship between center volume and use was assessed, distance hospital calculated status. survival using...
Primary graft dysfunction (PGD) is acute lung injury within 72 hours of transplantation. We hypothesized that cell-free hemoglobin (CFH) contributes to PGD by increasing microvascular permeability and tested this in patients, ex vivo human lungs, cultured endothelial cells. In a nested case control study 40 patients with severe at 80 matched controls without PGD, elevated preoperative CFH was independently associated increased risk (odds ratio [OR] 2.75, 95%CI, 1.23–6.16, P = 0.014). The...
Patients with idiopathic pulmonary arterial hypertension (IPAH) have improved survival after heart-lung transplantation (HLT) and double-lung (DLT). However, the optimal procedure for patients IPAH undergoing remains unclear. We hypothesized that critically ill patients, defined by admission to intensive care units (ICU), would demonstrate HLT vs. DLT. All adult (>18 yr) in Scientific Registry of Transplant Recipients (SRTR) database, who underwent either or DLT between 1987 2012, were...