A5101585871- Immune cells in cancer
- Pulmonary Hypertension Research and Treatments
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Research on Leishmaniasis Studies
- Neonatal and fetal brain pathology
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Phytochemical compounds biological activities
- Immunotherapy and Immune Responses
- Phytochemicals and Medicinal Plants
- Banana Cultivation and Research
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- Epilepsy research and treatment
- Insect Pest Control Strategies
- Traditional and Medicinal Uses of Annonaceae
- Medicinal Plants and Neuroprotection
- Cell death mechanisms and regulation
- EEG and Brain-Computer Interfaces
- Immune Response and Inflammation
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Toxin Mechanisms and Immunotoxins
Universidad de Antioquia
2014-2025
The University of Texas Southwestern Medical Center
2012-2025
Instituto de Investigación Biomédica de A Coruña
2023-2025
Southwestern Medical Center
2012-2025
Complexo Hospitalario Universitario A Coruña
2023-2025
Universidade de Santiago de Compostela
2015-2024
Center for Research in Molecular Medicine and Chronic Diseases
2015-2024
IRCCS Humanitas Research Hospital
2019-2024
Kaiser Permanente
2024
Los Angeles Medical Center
2024
We studied the organization of somatosensory cortex in proficient Braille readers, recording evoked potentials (SEPs) 10 subjects and using transcranial magnetic stimulation (TMS) five subjects, compared results with those 15 control subjects. Somatosensory were elicited by a focal electrical stimulus to tip index finger recorded from contralateral 4 x grid scalp electrodes centred around C3' C4'. Transcranial stimulation, an 8-shaped coil over same positions, was delivered simultaneously...
Engineered nanomaterials offer numerous and tantalizing opportunities in many sectors of society, including medicine. Needless to say, attention should also be paid the potential for unexpected hazardous effects these novel materials. To date, much nanotoxicology literature has focused on assessment cell viability or death using primitive assays detection plasma membrane integrity mitochondrial function cellular morphology. However, when assessing cytotoxic engineered nanomaterials,...
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was performed in the FP7-MARINA project, with objective to identify evaluate vitro test methods toxicity order facilitate development an intelligent testing strategy (ITS). Six representative oxide NMs provided by EC-JRC Repository were tested nine laboratories. evaluated 12 cellular models representing 6 different target...
Abstract Eosinophil peroxidase (EPO) is one of the major oxidant‐producing enzymes during inflammatory states in human lung. The degradation single‐walled carbon nanotubes (SWCNTs) upon incubation with EPO and H 2 O reported. Biodegradation SWCNTs higher presence NaBr, but neither alone nor caused nanotubes. Molecular modeling reveals two binding sites for on EPO, located at proximal side (same as catalytic site) other distal EPO. oxidized groups both cases are stabilized by electrostatic...
Single-walled carbon nanotubes (SWCNTs) have become potential candidates for a wide range of medical applications including sensing, imaging, and drug delivery. Their photophysical properties (i.e., the capacity to emit in near-infrared), excellent photostability, fluorescence, which is highly sensitive local environment, make SWCNTs promising optical probes biomedicine. In this Perspective, we discuss existing strategies challenges using diagnosis based on intracellular sensing as well also...
Background Tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of immune system to fight cancer and hinder antitumoral efficacy most treatments currently applied in clinic. Previous studies have evaluated response triggered by (TLR) agonists, such as poly(I:C), imiquimod (R837) or resiquimod (R848) monotherapies; however, their combination for treatment has not been explored. This study investigates macrophage reprogramming poly(I:C) combined with...
Respiratory syncytial virus (RSV) infection in lung transplant recipients is associated with high morbidity. This study evaluated the RSV fusion inhibitor presatovir RSV-infected recipients.
Background In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits ability of immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able reprogram TAMs towards M1-like antitumor effector cells. The objective our work has been develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, improve drug stability systemic toxicity, their targeting therapeutic...
Abstract Visual evoked responses (VERs) to brief light flashes were recorded from occipital regions in a group of 30 “cortically blind” children aged 4 months 15 years and compared with those 31 similar age range who had the same type central nervous system diseases but without signs or symptoms blindness. The VERs analyzed for amplitude, number peaks, morphology, follwing method used previously by other authors. All some degree abnormality, there no significant differences between two...
Abstract Carbon-based nanomaterials including carbon nanotubes (CNTs) have been shown to trigger inflammation. However, how these materials are ‘sensed’ by immune cells is not known. Here we compared the effects of two carbon-based nanomaterials, single-walled CNTs (SWCNTs) and graphene oxide (GO), on primary human monocyte-derived macrophages. Genome-wide transcriptomics assessment was performed at sub-cytotoxic doses. Pathway analysis microarray data revealed pronounced chemokine-encoding...
A model of risk potential for developmental outcome was created based on cardiac, medical, surgical, and family-stress factors in 31 children with transposition the great arteries who had undergone reparative open heart surgery utilizing cardiopulmonary bypass during infancy. Impact these assessed by 4 current neurologic measures (neurologic anatomic abnormalities, functional impairment, electroencephalograph [EEG], Pattern Visual Evoked Potential [PVEP]) psychologic (IQ, achievement,...
Neutrophils extrude neutrophil extracellular traps (NETs) consisting of a network chromatin decorated with antimicrobial proteins to enable non-phagocytic killing microorganisms. Here, utilizing model ex vivo activated human neutrophils, we present evidence entrapment and degradation carboxylated single-walled carbon nanotubes (SWCNTs) in NETs. The SWCNTs was catalyzed by myeloperoxidase (MPO) purified NETs the reaction facilitated addition H2O2 NaBr. These results show that can undergo...
Based on the previously reported in vitro antiplasmodial activity of several xanthones from Garcinia mangostana , two xanthones, α‐mangostin and a new compound, δ‐mangostin, were isolated mangosteen husk, cytotoxic effects determined. α‐Mangostin was more active against resistant Plasmodium falciparum chloroquine‐resistant (FCR3) strain (IC 50 = 0.2 ± 0.01 μM) than δ‐mangostin 121.2 1.0 μM). Furthermore, therapeutic response according to administration route evaluated berghei malarial murine...
Abstract Macrophage plasticity is the ability of mononuclear phagocytes to change phenotype, function, and genetic reprogramming upon encounter specific local stimuli. In tumor microenvironment, Tumor‐Associated Macrophages (TAMs) acquire an immune‐suppressive tumor‐promoting phenotype. With aim re‐educate TAMs antitumor effectors, in this study, we used two immunestimulatory compounds: TLR7 agonist Imiquimod (IMQ) TLR3 Poly(I:C). To better mimic vitro response TAMs, Tumor‐Conditioned...