A5101710545- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Cancer survivorship and care
- Family Support in Illness
- Chemotherapy-induced cardiotoxicity and mitigation
- Palliative Care and End-of-Life Issues
- Adolescent and Pediatric Healthcare
- Cancer Risks and Factors
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Sarcoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Resilience and Mental Health
- Polyomavirus and related diseases
- Lymphatic System and Diseases
- Cancer-related cognitive impairment studies
- Testicular diseases and treatments
- Optimism, Hope, and Well-being
- Renal Transplantation Outcomes and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Neuroblastoma Research and Treatments
- Multiple and Secondary Primary Cancers
- Autoimmune and Inflammatory Disorders Research
Fred Hutch Cancer Center
2016-2025
University of Washington
2016-2025
University of Colorado Denver
2025
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2010-2024
Seattle Children's Hospital
2013-2023
University of Minnesota System
2005-2022
Stony Brook University Hospital
2014-2022
Cancer Research Center
2005-2021
Center for Cancer and Blood Disorders
2015-2021
Michigan State University
2019-2021
To identify risk factors associated with outcomes in children metastatic rhabdomyosarcoma (RMS) treated on the fourth Intergroup Rhabdomyosarcoma Study (IRS-IV).Patients RMS were one of two regimens that incorporated a window either ifosfamide and etoposide (IE) vincristine, dactinomycin, cyclophosphamide (VAC) or melphalan (VM) VAC. end points failure-free survival (FFS) overall (OS). Clinical including age, histology, sites primary disease, number disease correlated those points.One...
Abstract Background Physical activity (PA) may be important for preventing chronic diseases adolescent and young adult (AYA) childhood cancer survivors. Randomized controlled trials (RCTs) of PA interventions AYA survivors are sparse, but necessary to determine effective programs increasing among this population. Thus, we conducted a pilot RCT, testing the feasibility mobile health (mHealth) intervention promote Procedure We recruited 14– 18–year–olds who were ≥1‐year post therapy from...
Abstract Background Adolescents and young adults (AYAs) with cancer are at risk for poor psychosocial outcomes. This study aimed to determine whether a novel intervention targeting resilience resources would improve patient‐reported resilience, quality of life, psychological distress. Methods In this parallel, phase 2 randomized controlled trial, English‐speaking AYAs (12‐25 years old) were the Promoting Resilience in Stress Management (PRISM) or usual care (UC). PRISM is brief, skills‐based...
To determine the incidence and risk factors for development of new malignancies occurring after stem-cell transplantation (SCT).Between January 1, 1974, March 31, 2001, 3,372 patients underwent SCT at University Minnesota. From these transplants, 147 posttransplant (PTMs) were identified in 137 patients.Excluding nonmelanoma skin cancers (n = 19) carcinoma-in-situ 5), remaining 123 cases represented an 8.1-fold (95% confidence interval [CI], 6.7 to 9.6) increased a PTM, excess 102.7...
The purpose of the study was to determine prevalence metabolic syndrome, growth hormone deficiency, and cardiovascular risk factors among adult survivors childhood acute lymphoblastic leukemia (ALL) treated with or without cranial irradiation.Follow-up undertaken 75 randomly selected long-term ALL survivors. Testing included fasting insulin, glucose, lipids, (GH) releasing plus arginine stimulation test. syndrome compared population norms from 1999-2002 National Health Nutrition Examination...
To examine the feasibility and format of Promoting Resilience in Stress Management (PRISM) intervention among two groups adolescents young adults (AYAs) at-risk for poor outcomes: those with Type 1 diabetes (T1D) or cancer.PRISM consists long four short skills-based modules. English-speaking patients 12-25 years old were eligible if they had T1D >6 months cancer >2 weeks. Feasibility was defined as an 80% completion rate high satisfaction. Ongoing monitoring shaped iterative refinement...
Many cancer survivors experience physical and/or psychosocial side effects, which can be severe, debilitating, and sometimes permanent. These NCCN Guidelines for Survivorship provide screening, evaluation, treatment recommendations common consequences of health care professionals who work with adult-onset in the posttreatment period. introductory sections guidelines include panel's definition survivors, a discussion effects its treatment, general principles standards survivorship care,...
The current study was performed to describe frequencies and risk factors of altered oral health odontogenesis in childhood cancer survivors.In total, 9308 survivors who were diagnosed between 1970 1986 2951 siblings from the Childhood Cancer Survivor Study completed a survey that contained oral-dental information. authors analyzed treatment impact, socioeconomic data, patient demographics on dental outcomes using univariate multivariate logistic regression models estimate odds ratios...
Childhood cancer survivors (CCSs) are at risk for physical disability. The aim of this investigation was to characterize and compare performance among CCSs a group siblings age < 18 years determine if diagnosis, treatment, activity levels were associated with lower scores.CCSs ≥ 5 from diagnosis sibling comparison recruited evaluated strength, mobility, fitness. Physical measures compared in regression models between by treatment exposures levels.CCSs (n = 183; mean ± standard deviation...
Background The psychosocial function of parents children with cancer can impact the well-being entire family. Resilience resources are likely related to outcomes and may be amenable intervention. We hypothesized that lower would report worse outcomes. Methods In "Understanding in Parents Children Cancer" study, comprehensive surveys were mailed consecutive, English-speaking who treated at Seattle Children's Hospital completed therapy between January 1, 2009 December 31, 2010. measured by...
Long-term morbidity after hematopoietic cell transplantation (HCT) is unknown. The risk of physical and psychological health in 324 patients who had survived 10 or more years HCT a sibling comparison group (n = 309) was evaluated. Using the Common Terminology Criteria for Adverse Events, 15-year cumulative incidence severe/life-threatening/fatal conditions 41% (95% confidence interval, 34% to 48%). survivors were 5.7 times as likely develop severe/life-threatening condition (P < .001) 2.7...
BACKGROUND Low patient‐reported resilience is associated with an ongoing risk of poor health and psychosocial outcomes. Using a large cross‐sectional sample survivors hematopoietic cell transplantation (HCT), this study explored associations between resilience, psychological distress, posttraumatic growth, health‐related quality life. METHODS Between July 1, 2013 June 30, 2014, the annual Fred Hutchinson Cancer Research Center (FHCRC) posttransplant survivorship survey queried functional...
The authors sought to better understand the combined effects of pretransplant, transplant, and post-transplant factors in determining risks serious cardiovascular disease after hematopoietic cell transplantation (HCT). Hospitalizations deaths associated with outcomes were identified among 1379 Washington State residents who received HCT (57% allogeneic 43% autologous) at a single center from 1985 2005, survived ≥ 2 years, followed through 2008. Using nested case-cohort design, relationships...