A5006192909- Sarcoma Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Infection Control in Healthcare
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Orthopedic Infections and Treatments
- Liver Disease and Transplantation
- Orthopaedic implants and arthroplasty
- Organ Transplantation Techniques and Outcomes
- Birth, Development, and Health
- Total Knee Arthroplasty Outcomes
- Clinical Nutrition and Gastroenterology
- Retinoids in leukemia and cellular processes
- Cardiac Structural Anomalies and Repair
- Bacterial Identification and Susceptibility Testing
- Infant Nutrition and Health
- Nutritional Studies and Diet
- Acute Myeloid Leukemia Research
- Testicular diseases and treatments
- Renal Transplantation Outcomes and Treatments
- Vitamin D Research Studies
- Central Venous Catheters and Hemodialysis
- Antibiotic Use and Resistance
- Acute Lymphoblastic Leukemia research
- Surgical site infection prevention
University of Nebraska Medical Center
2016-2025
Nebraska Medical Center
2014-2024
New York Proton Center
2015-2024
Communities In Schools of Orange County
2022-2024
Oregon Medical Research Center
2022-2024
Lindsay Unified School District
2022-2024
University of Pittsburgh
2022-2024
Health Innovations (United States)
2024
Houston Methodist
2023
Methodist Hospital
2023
To identify risk factors associated with outcomes in children metastatic rhabdomyosarcoma (RMS) treated on the fourth Intergroup Rhabdomyosarcoma Study (IRS-IV).Patients RMS were one of two regimens that incorporated a window either ifosfamide and etoposide (IE) vincristine, dactinomycin, cyclophosphamide (VAC) or melphalan (VM) VAC. end points failure-free survival (FFS) overall (OS). Clinical including age, histology, sites primary disease, number disease correlated those points.One...
To identify risk factors associated with outcome in children metastatic rhabdomyosarcoma a large cohort of patientsPooled data were obtained from 788 patients treated nine studies performed by European and American cooperative groups. Clinical factors, including age, histology, site primary, site(s) number sites disease, correlated event-free survival (EFS) overall (OS).Seven hundred eighty-eight eligible for analysis. The 3-year OS EFS 34% (SE, 1.7) 27% 1.6), respectively. By univariate...
Patients with metastatic rhabdomyosarcoma (RMS), except those younger than 10 years embryonal RMS, have an estimated long-term event-free survival (EFS) of less 20%. The main goal this study was to improve outcome patients RMS by dose intensification interval compression, use the most active agents determined in phase II window studies, and irinotecan as a radiation sensitizer.Patients received 54 weeks therapy: blocks therapy vincristine/irinotecan (weeks 1 6, 20 25, 47 52), compression...
Purpose To estimate the antitumor activity and toxicity of irinotecan alone in combination with vincristine when administered as window therapy standard chemotherapy pediatric patients newly diagnosed metastatic rhabdomyosarcoma. Patients Methods Nineteen younger than age 21 years rhabdomyosarcoma or undifferentiated sarcoma received two cycles (20 mg/m 2 daily for 5 days, repeated weeks) 50 1.5 (weeks 0, 1, 3, 4) weeks). who achieved a partial response (PR) complete (CR) these agents...
Recent findings suggest that marital status affects survival in patients with different types of cancer. However, its role the pancreatic ductal adenocarcinoma is unknown. In this study, we investigated whether there was an association between and overall (OS) (PDAC).Adult diagnosed PDAC 1998 2003 known statuses were identified from Surveillance, Epidemiology, End Results registry National Cancer Institute. OS for these plotted using Kaplan-Meier method. Comparative risks mortality evaluated...
To simplify the recommended staging evaluation by correlating tumor and clinical features with patterns of distant metastasis in newly diagnosed patients embryonal rhabdomyosarcoma (ERMS) or alveolar (ARMS).Patient data from Intergroup Rhabdomyosarcoma Study Group Children's Oncology over two periods were analyzed: 1991 to 1997 1999 2004. We used recursive partitioning analyses identify factors (including histology, age, regional nodal metastatic status, size, local invasiveness, primary...
The primary aim of this clinical trial was to prioritize bevacizumab or temsirolimus for additional investigation in rhabdomyosarcoma (RMS) when administered combination with cytotoxic chemotherapy patients RMS first relapse unfavorable prognosis.Patients were randomly assigned receive on day 1 days 1, 8, and 15 each 21-day treatment cycle, together vinorelbine cyclophosphamide a maximum 12 cycles. Local tumor control surgery and/or radiation therapy permitted after 6 weeks treatment. end...
Abstract Background Specialty societies, including the Infectious Diseases Society of America, strive to address gender and racial inequities in professional advancement. Microaggressions remain a persistent pervasive barrier these goals. Nonprofessional speaker introductions are manifestation race- gender-based microaggressions, which have not been previously assessed at IDWeek. We disparities IDWeek over 7-year period that included formal equity initiatives introduced 2016. Methods...
Regional lymph node disease (RLND) is a component of the risk-based treatment stratification in rhabdomyosarcoma (RMS). The purpose this study was to determine contribution RLND prognosis for patients with RMS.Patient characteristics and survival outcomes enrolled onto Intergroup Rhabdomyosarcoma Study IV (N = 898, 1991 1997) were evaluated among following three patient groups: nonmetastatic clinical or pathologic negative nodes (N0, 696 patients); positive (N1, 125 single site metastatic...
To compare response rates for two schedules of irinotecan with vincristine in patients rhabdomyosarcoma at first relapse or disease progression.Patients progression and an unfavorable prognosis were randomly assigned to one treatment vincristine: regimen 1A included 20 mg/m(2)/d intravenously 5 days weeks 1, 2, 4, 1.5 mg/m(2) administered on day 1 5; 1B 50 4 as 1A. Disease was assessed week 6. Those responsive continued receive 44 multiagent chemotherapy that incorporated the...
Blood culture contamination is a clinically significant problem that results in patient harm and excess cost. In prospective, controlled trial at an academic center Emergency Department, device diverts sequesters the initial 1.5–2 mL portion of blood (which presumably carries contaminating skin cells microbes) was tested against standard phlebotomy procedures patients requiring cultures due to clinical suspicion serious infection. sum, 971 subjects granted informed consent were enrolled...
Abstract BACKGROUND: Rhabdomyosarcoma (RMS), the most common soft‐tissue sarcoma in children, occurs less commonly infants. Historically, poorer outcomes have been reported for infants diagnosed with RMS than older children. METHODS: The authors analyzed characteristics, treatment administered, outcomes, and patterns of failure aged < 1 year nonmetastatic who received multimodal therapy on Intergroup Study (IRS) protocols IRS‐IV, D9602, D9803. RESULTS: Seventy‐six were treated 3 from 1991...
Omega-3 fatty acids play critical roles during fetal growth and development with increased intakes associated improved maternal-fetal outcomes. acid intake in Western diets is low, the impact of socioeconomic factors on omega-3 pregnant women childbearing age has not been reported. We used National Health Nutrition Examination Survey (NHANES) cycles 2003–2012 to assess relationship between age. Out 7266 eligible participants, 6478 were age, while 788 identified as at time survey. Mean...
Extensive research supports a protective effect of high-fiber diet in certain disease states; however, little is known about its relationship to lung health. The National Health and Nutrition Examination Surveys (NHANES) contain spirometry measures dietary intake information, allowing us assess this relationship.Determine the association between fiber function representative sample U.S. adults.Participants included 1,921 adults who had measurements available. primary outcomes were...
Human milk is the optimal food for human infants, including infants born prematurely. In event that a mother of hospitalized infant cannot provide breast milk, donor considered an acceptable alternative. It known macronutrient composition different than with variable fat content and protein content. However, much less about micronutrient nutritional antioxidants. Samples from 12 mothers in Newborn Intensive Care Unit until were collected analyzed concentrations antioxidants, α-carotene,...
Management of post-transplant diabetes mellitus is challenging; there a lack prospective randomized controlled trials for safety and efficacy antidiabetic medications in solid organ recipients. Glucagon-like peptide 1 receptor agonists (GLP-1RA) are relatively new class used to manage type 2 the general population. They have several benefits besides glycemic control, including weight loss improved cardiovascular risk. However, they not been studied extensively population efficacy. We...
PURPOSE: To investigate the antitumor activity and toxicity of topotecan, used alone in combination with conventional therapy, patients metastatic rhabdomyosarcoma (RMS). PATIENTS AND METHODS: Forty-eight younger than 21 years age newly diagnosed RMS received 2.0 to 2.4 mg/m 2 topotecan intravenously daily for 5 days every before standard therapy. Two courses were given absence progressive disease or excessive response was assessed. Patients at least a partial (PR) proceeded therapy...