A5009794067- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related cognitive impairment studies
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Adolescent and Pediatric Healthcare
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Nutrition and Health in Aging
- Cancer survivorship and care
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Coenzyme Q10 studies and effects
- Renal and related cancers
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- Congenital Diaphragmatic Hernia Studies
- Lymphoma Diagnosis and Treatment
- Cancer Risks and Factors
- Frailty in Older Adults
- Neuroblastoma Research and Treatments
- Mitochondrial Function and Pathology
- Neonatal Respiratory Health Research
St. Jude Children's Research Hospital
2016-2025
University of Tennessee Health Science Center
2013-2022
University of Tennessee at Knoxville
2013-2020
Cancer Research Center
2009-2018
The University of Texas Health Science Center at San Antonio
2018
City of Hope
2018
Fred Hutch Cancer Center
2009-2017
University of Alberta
2017
Baylor College of Medicine
2016
Wake Forest University
2016
Adult survivors of childhood cancer are known to be at risk for treatment-related adverse health outcomes. A large population has not been evaluated using a comprehensive systematic clinical assessment determine the prevalence chronic conditions.To outcomes and proportion associated with exposures in cohort adult cancer.Presence was ascertained exposure-based medical assessments among 1713 (median age, 32 [range, 18-60] years) time from diagnosis, 25 10-47] enrolled St Jude Lifetime Cohort...
<b>Objectives </b>To assess the incidence of and risks for congestive heart failure, myocardial infarction, pericardial disease, valvular abnormalities among adult survivors childhood adolescent cancers. <b>Design </b>Retrospective cohort study. <b>Setting </b>26 institutions that participated in Childhood Cancer Survivor Study. <b>Participants </b>14 358 five year cancer diagnosed under age 21 with leukaemia, brain cancer, Hodgkin’s lymphoma, non-Hodgkin’s kidney neuroblastoma, soft tissue...
To evaluate the relative contribution of modifiable cardiovascular risk factors on development major cardiac events in aging adult survivors childhood cancer.Among 10,724 5-year (median age, 33.7 years) and 3,159 siblings Childhood Cancer Survivor Study, prevalence hypertension, diabetes mellitus, dyslipidemia, obesity was determined, along with incidence severity such as coronary artery disease, heart failure, valvular arrhythmia. On longitudinal follow-up, rate ratios (RRs) subsequent...
Frailty, a phenotype reported among 9.9% of individuals 65 years old and older (9.6% women; 5.2% men), has not been assessed adult childhood cancer survivors (CCS). We estimated the prevalence frailty examined associations with morbidity mortality.
Purpose To create clinically useful models that incorporate readily available demographic and cancer treatment characteristics to predict individual risk of heart failure among 5-year survivors childhood cancer. Patients Methods Survivors in the Childhood Cancer Survivor Study (CCSS) free significant cardiovascular disease 5 years after diagnosis (n = 13,060) were observed through age 40 for development (ie, requiring medications or transplantation leading death). Siblings 4,023) established...
Background: Studies of cardiac disease among adult survivors childhood cancer have generally relied on self-reported or registry-based data. Objective: To systematically assess outcomes cancer. Design: Cross-sectional study. Setting: St. Jude Children's Research Hospital. Patients: 1853 cancer, aged 18 years older, who received cancer-related cardiotoxic therapy at least 10 earlier. Measurements: Baseline history and physical examination, fasting metabolic lipid panels, echocardiography,...
BACKGROUND Childhood cancer survivors (CCS) are at an increased risk of developing metabolic syndrome (MetSyn), which may be reduced with lifestyle modifications. The purpose this investigation was to characterize habits and associations MetSyn among CCS. METHODS CCS who were ≥ 10 years from diagnosis, aged > 18 years, participating in the St. Jude Lifetime Cohort Study completed medical laboratory tests a food frequency questionnaire. Third Report National Cholesterol Education Program...
Abstract BACKGROUND: Long‐term survivors of childhood cancer are at risk for fatigue, sleep problems, and neurocognitive impairment, although the association between these outcomes has not been previously examined. METHODS: Outcomes were evaluated in 1426 from Childhood Cancer Survivor Study using a validated Neurocognitive Questionnaire. Relative risks impairment calculated demographic treatment factors, survivors' report on Functional Assessment Chronic Illness Therapy‐Fatigue, Short...
Childhood cancer survivors (CCSs) are at risk for physical disability. The aim of this investigation was to characterize and compare performance among CCSs a group siblings age < 18 years determine if diagnosis, treatment, activity levels were associated with lower scores.CCSs ≥ 5 from diagnosis sibling comparison recruited evaluated strength, mobility, fitness. Physical measures compared in regression models between by treatment exposures levels.CCSs (n = 183; mean ± standard deviation...
Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors childhood cancer. Patients Methods Participants the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for development stroke. Siblings (n 4,023) established baseline population risk. Piecewise exponential models with backward selection estimated relationships between potential predictors each outcome. The St Jude Lifetime Cohort 1,842) Emma Children’s...
Abstract Objective To investigate the impact of modifications to contemporary cancer protocols, which minimize exposures cardiotoxic treatments and preserve long term health, on serious cardiac outcomes among adult survivors childhood cancer. Design Retrospective cohort study. Setting 27 institutions participating in Childhood Cancer Survivor Study. Participants 23 462 five year (6193 (26.4%) treated 1970s, 9363 (39.9%) 1980s, 7906 (33.6%) 1990s) leukemia, brain cancer, Hodgkin lymphoma,...
The impacts of radiotherapy dose and exposed cardiac volume, select chemotherapeutic agents, age at exposure on risk for late-onset disease in survivors childhood cancer remain unresolved.We determined the rates severe to fatal 24,214 5-year Childhood Cancer Survivor Study diagnosed between 1970 1999 a median 7.0 years (range, 0 20.9 years), with attained 27.5 5.6 58.9 years). Using piecewise exponential models, we evaluated association demographic treatment characteristics.The cumulative...
To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort.Adult of siblings, all participants the Childhood Cancer Survivor Study, completed three surveys assessing status. At each time points, were classified as having poor outcomes general health, mental function, or daily activities if they indicated moderate to extreme impairment. Generalized linear mixed models used with siblings for outcome function age identify host- treatment-related...
Background: Hypertension potentiates cardiovascular risk in survivors of childhood cancer previously exposed to cardiotoxic therapies, so it is important determine the prevalence and factors for hypertensive blood pressure this high-risk group.Methods: Participants included 3,016 adult 10-year who had resting measurements performed at St. Jude Children's Research Hospital (Memphis, TN). We characterized status participants, calculated standardized ratios based on U.S. population rates,...
Abstract Background Childhood cancer survivors have an increased risk of heart failure, ischemic disease, and stroke. They may benefit from prediction models that account for cardiotoxic treatment exposures combined with information on traditional cardiovascular factors such as hypertension, dyslipidemia, diabetes. Methods Cancer Survivor Study participants (n = 22 643) were followed through age 50 years incident Siblings 5056) served a comparator. Participants assessed longitudinally...