A5084551863- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Effects of Radiation Exposure
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Esophageal Cancer Research and Treatment
- Renal and related cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Advances in Oncology and Radiotherapy
- Respiratory Support and Mechanisms
- Neurological Complications and Syndromes
- Testicular diseases and treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Renal function and acid-base balance
- Sarcoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Thermal Regulation in Medicine
- Neonatal Respiratory Health Research
- Spine and Intervertebral Disc Pathology
Amsterdam University Medical Centers
2018-2024
University of Amsterdam
2017-2024
Cancer Center Amsterdam
2023-2024
Institute of Oncology Ljubljana
2020
Amsterdam UMC Location University of Amsterdam
2010-2018
Fred Hutch Cancer Center
2017
St. Jude Children's Research Hospital
2017
University of Alberta
2017
Boston Children's Hospital
2013
Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors childhood cancer. Patients Methods Participants the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for development stroke. Siblings (n 4,023) established baseline population risk. Piecewise exponential models with backward selection estimated relationships between potential predictors each outcome. The St Jude Lifetime Cohort 1,842) Emma Children’s...
Abstract Background During the day-night cycle, gravity and applied stress to body mass spine causes a decrease in height, which is restored overnight. This diurnal length variation has not yet been quantified during radiotherapy. Therefore, we aimed quantify on cone beam CTs (CBCTs) of pediatric patients (< 18 years) who underwent Methods For this retrospective study, included 32 (mean age 10.0, range 2.7–16.1 received image guided radiotherapy between 2012 2018 two institutes. Patients...
Abstract Background Due to respiratory motion, accurate radiotherapy delivery thoracic and abdominal tumors is challenging. We aimed quantify the ability of mechanical ventilation reduce by measuring diaphragm motion magnitudes in same volunteers during free breathing (FB) , mechanically regularized (RB) at 22 breaths per minute (brpm), variation mean position across multiple deep inspiration breath-holds (DIBH) drift single prolonged (PBH) two MRI sessions. Methods In sessions, MRIs were...
Background: Pediatric safety margins are generally based on data from adult studies; however, adult-based might be too large for children. The aim of this study was to quantify and compare interfractional organ position variation in children adults.Material methods: For 35 adults treated with thoracic/abdominal irradiation, 850 (range 5–30 per patient) retrospectively collected cone beam CT images were registered the reference that used radiation treatment planning purposes. Renal assessed...
Respiratory motion presents a challenge in radiotherapy of thoracic and upper abdominal tumors. Techniques to account for respiratory include tracking. Using magnetic resonance imaging (MRI) guided systems, tumors can be tracked continuously. conventional linear accelerators, tracking lung is possible by determining tumor on kilo voltage (kV) imaging. But with kV hampered limited contrast. Therefore, surrogates the are used. One diaphragm. However, there no universal method establishing...
Interfractional organ position variation might differ for abdominal organs and this could have consequences defining safety margins. Therefore, the purpose of study is to quantify interfractional variations in children order investigate possible correlations between determine whether location-dependent.For 20 (2.2-17.8 years), we retrospectively analyzed 113 CBCTs acquired during treatment course, which were registered reference CT assess liver, spleen, kidneys, both diaphragm domes. Organ...
The aim of this study is to establish the first step toward a novel and highly individualized three-dimensional (3D) dose distribution reconstruction method, based on CT scans organ delineations recently treated patients. Specifically, feasibility automatically selecting scan childhood cancer patient who similar given historically child suffered from Wilms' tumor assessed.A cohort 37 children between 2- 6-yr old are considered. Five potential notions ground-truth similarity proposed, each...
Purpose The purpose of this work was to assess the feasibility using surrogate CT scans matched patients for organ dose reconstructions childhood cancer (CC) survivors, treated in past with only 2D imaging data available instead 3D data, and particular current literature standard matching based on similarity age gender. Methods Thirty‐one recently CC abdominal were divided into six age‐ gender‐matched groups. From each group, two radiotherapy plans Wilms’ tumor selected as reference applied...
In adults, a single pre-treatment four-dimensional CT (4D-CT) acquisition is often used to account for respiratory-induced target motion during radiotherapy. However, studies have indicated that 4D-CT not always representative respiratory motion. Our aim was investigate whether diaphragm in children on 4DCT can accurately predict as observed cone beam CTs (CBCTs).Twelve patients (mean age 14.5 yrs.; range 8.6-17.9 yrs) were retrospectively included based visibility of the abdominal or...
For accurate thoracic and abdominal radiotherapy, inter- intrafractional geometrical uncertainties need to be considered enable margin sizes. We aim quantify interfractional diaphragm organ position variations, motion in a large multicenter cohort of pediatric cancer patients (< 18 years). investigated the correlation variations with age, general anesthesia (GA).In 189 children (mean age 8.1; range 0.4-17.9 years) from six institutes, variation both hemidiaphragms, spleen, liver, left right...
PurposeOur purpose was to validate and compare the performance of 4 organ dose reconstruction approaches for historical radiation treatment planning based on 2-dimensional radiographs.Methods MaterialsWe considered 10 patients with Wilms tumor computed tomography images whom we developed typical historic plans, using anteroposterior posteroanterior parallel-opposed 6 MV flank fields, normalized 14.4 Gy. Two plans were created each patient, without corner blocking. Regions interest (lungs,...
Abstract Background While four‐dimensional computed tomography (4 DCT ) is extensively used in adults, reluctance remains to use 4 children. Day‐to‐day (interfractional) variability and irregular respiration (intrafractional variability) have shown be limiting factors of effectiveness adults. In order evaluate applicability children, the purpose this study quantify inter‐ intrafractional respiratory motion children The pooled analysis enables a solid comparison reveal if application for...
In retrospective radiation treatment (RT) dosimetry, a surrogate anatomy is often used for patients without 3D CT. To gain insight in what the crucial aspects are to enable accurate dose reconstruction, we investigated relation of patient characteristics and internal anatomical features with deviations reconstructed organ using patient's CT scans. Abdominal scans 35 childhood cancer (age: 2.1–5.6 yr; 17 boys, 18 girls) undergoing RT during 2004–2016 were included. Based on whether an intact...