A5100378167- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced cardiotoxicity and mitigation
- Maternal and fetal healthcare
- Adolescent and Pediatric Healthcare
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- Mitochondrial Function and Pathology
- Pediatric Urology and Nephrology Studies
- Menstrual Health and Disorders
- Urological Disorders and Treatments
- Neonatal and fetal brain pathology
- Pregnancy and preeclampsia studies
- Renal and related cancers
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Pregnancy-related medical research
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Gestational Trophoblastic Disease Studies
- Neonatal Health and Biochemistry
- Coenzyme Q10 studies and effects
- Maternal and Perinatal Health Interventions
- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
St. Jude Children's Research Hospital
2010-2025
XinHua Hospital
2019-2024
Shanghai Jiao Tong University
2014-2024
University of Alberta
2014-2023
University of Calgary
2018-2023
Kunming Medical University
2022
International Peace Maternity & Child Health Hospital
2014-2022
Changsha Hospital for Maternal and Child Health Care
2021
Shanghai First Maternity and Infant Hospital
2020
Jiangmen Central Hospital
2020
To evaluate the relative contribution of modifiable cardiovascular risk factors on development major cardiac events in aging adult survivors childhood cancer.Among 10,724 5-year (median age, 33.7 years) and 3,159 siblings Childhood Cancer Survivor Study, prevalence hypertension, diabetes mellitus, dyslipidemia, obesity was determined, along with incidence severity such as coronary artery disease, heart failure, valvular arrhythmia. On longitudinal follow-up, rate ratios (RRs) subsequent...
Among patients in whom childhood cancer was diagnosed the 1970s and 1980s, 18% of those who survived for 5 years died within subsequent 25 years. In recent decades, treatments have been modified with goal reducing life-threatening late effects.
Abstract Background: Childhood cancer survivors are at higher risk of morbidity and mortality from cardiovascular disease compared with the general population. Methods: Eight thousand five hundred ninety-nine (52% male) 2,936 siblings (46% Cancer Survivor Study, a retrospectively ascertained, prospectively followed study persons who survived 5 years after childhood diagnosed 1970 to 1986, were evaluated for body mass index ≥30 kg/m2 based on self-reported heights weights use medications...
Purpose To create clinically useful models that incorporate readily available demographic and cancer treatment characteristics to predict individual risk of heart failure among 5-year survivors childhood cancer. Patients Methods Survivors in the Childhood Cancer Survivor Study (CCSS) free significant cardiovascular disease 5 years after diagnosis (n = 13,060) were observed through age 40 for development (ie, requiring medications or transplantation leading death). Siblings 4,023) established...
Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors childhood cancer. Patients Methods Participants the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for development stroke. Siblings (n 4,023) established baseline population risk. Piecewise exponential models with backward selection estimated relationships between potential predictors each outcome. The St Jude Lifetime Cohort 1,842) Emma Children’s...
Abstract Background Childhood cancer survivors have an increased risk of heart failure, ischemic disease, and stroke. They may benefit from prediction models that account for cardiotoxic treatment exposures combined with information on traditional cardiovascular factors such as hypertension, dyslipidemia, diabetes. Methods Cancer Survivor Study participants (n = 22 643) were followed through age 50 years incident Siblings 5056) served a comparator. Participants assessed longitudinally...
Risk-stratified therapy, which modifies treatment on the basis of clinical and biologic features, has improved 5-year overall survival childhood acute lymphoblastic leukemia (ALL) to 90%, but its impact long-term toxicity remains unknown.We assessed all-cause health-related late mortality (including effects cancer therapy), subsequent malignant neoplasms (SMNs), chronic health conditions, neurocognitive outcomes among 6,148 survivors ALL (median age, 27.9 years; range, 5.9-61.9 years)...
Background Determine the prevalence and predictors associated with underdiagnosis undertreatment of modifiable cardiovascular disease (CVD) risk factors (hypertension, dyslipidemia, glucose intolerance/diabetes) among adult survivors childhood cancer at high premature CVD. Methods Results This was a cross‐sectional study adult‐aged treated anthracyclines or chest radiotherapy, recruited across 9 US metropolitan regions. Survivors completed questionnaires in‐home clinical assessments. The...
Little is known about infections among adult survivors of childhood cancer. The authors report the occurrence and risk factors for in a large cohort cancer.The Childhood Cancer Survivor Study was used to compare incidence rates 12,360 5-year cancer with 4023 siblings. Infection-related mortality compared that US population. Demographic treatment variables were analyzed using Poisson regression determine rate ratios (RRs) corresponding 95% confidence intervals (CIs) associations infectious...
BACKGROUND Pulmonary complications after cancer therapy are varied. This study describes pulmonary outcomes among childhood survivors and evaluates their impact on daily activities. METHODS The incidence of (asthma, chronic cough, emphysema, lung fibrosis, oxygen need, recurrent pneumonia) reported 5‐year (n = 14,316) the death due to causes all eligible 20,690) in Childhood Cancer Survivor Study were compared with those for sibling controls 4027) cumulative incidence, standardized mortality...
The effect of temporal changes in cancer therapy on health status among childhood survivors has not been evaluated.To compare proportions self-reported adverse outcomes across 3 decades.Cross-sectional. (ClinicalTrials.gov: NCT01120353).27 North American institutions.14 566 adults, who survived for 5 or more years after initial diagnosis (median age, 27 years; range, 18 to 48 years), treated from 1970 1999.Patient report poor general mental health, functional impairment, activity limitation,...
To evaluate childhood cancer survivors' adherence to surveillance protocols for late effects of treatment and determine the factors affecting adherence.Between 2014 2016, 11,337 survivors 2,146 siblings in Childhood Cancer Survivor Study completed a survey ascertaining Children's Oncology Group (COG) guidelines at high risk second malignant neoplasms or cardiac dysfunction American Society (ACS) screening average-risk populations. Adherence rates were analyzed.Median age diagnosis was 7...
Abstract PURPOSE It is not known whether temporal changes in childhood cancer therapy have reduced risk of subsequent malignant neoplasms (SMNs) the central nervous system (CNS), a frequently fatal late effect therapy. METHODS Five-year survivors primary cancers diagnosed between 1970-1999 Childhood Cancer Survivor Study with CNS SMN were identified. Cumulative incidence rates and standardized ratios (SIR) compared among 1970-1979 (N = 6223), 1980-1989 9680), 1990–1999 8999). Multivariable...
Abstract While >85% of children with cancer will become five-year survivors, they are at substantially increased risk developing subsequent neoplasms (SNs) in part due to DNA-damaging therapy. However, the effects primary therapy on SN genomic landscape unknown. We utilized biospecimens collected through Childhood Cancer Survivor Study (CCSS) and employed whole-genome, exome, RNA sequencing analyze 199 SNs (median diagnosis age 37.8 years, range 13.0-54.4) matched germline tissue from...
Adult survivors of childhood central nervous system (CNS) tumors may be at risk for pulmonary dysfunction. This study enumerates the incidence dysfunction and explores associations between craniospinal irradiation (CSI) among CNS tumors.Participants included Childhood Cancer Survivor Study (CCSS) cohort members treated malignancies when <age 21, who survived 5+ years, sibling comparisons. Medical records were abstracted participants completed questionnaires that asked about nature timing...
PURPOSE To investigate longitudinal associations between physical activity (PA) and neurocognitive problems in adult survivors of childhood cancer. METHODS A total 12,123 5-year diagnosed 1970 1999 (median [range] age at diagnosis, 7 [0-21] years, time since diagnosis baseline, 16 [6-30] years) 720 siblings self-reported PA problems. was collected data were obtained (1-12) years 12 (9-14) later. consistency defined as any combination ≥ 75 minutes vigorous or 150 moderate per week on all...
Abstract Cardiomyopathy occurs at significantly higher rates in survivors of childhood cancer than the general population, but few studies have evaluated racial or ethnic disparities, and none assessed potential genetic factors contributing to this outcome. In study, African ancestry exposed cardiotoxic therapies (anthracyclines and/or heart radiotherapy; n = 246) were compared with cardiotoxic-exposed European (n 1,645) St. Jude Lifetime Cohort. Genetic variants examined using whole-genome...
To estimate the prevalence of financial hardship among adult survivors childhood cancer compared with siblings and identify sociodemographic, diagnosis, treatment correlates in era after implementation Affordable Care Act.
Kidney failure is a rare but serious late effect following treatment for childhood cancer. We developed model using demographic and characteristics to predict individual risk of kidney among 5-year survivors
Importance Cardiovascular disease is the leading noncancer cause of premature death among survivors childhood cancer. Adult cancer are largely managed by primary care practitioners (PCPs), and health utilization patterns related to cardiovascular screening not well described. Objective To examine at high risk for complications. Design, Setting, Participants This multicenter cross-sectional study included participants enrolled in a randomized clinical trial from 2017 2021. Abstracted...
Background Use of an emergency peripartum hysterectomy (EPH) as a lifesaving measure to manage intractable postpartum hemorrhage (PPH) appears be increasing recently around the world, and indications for EPH have changed. The object this study is identify risk factors associated with EPH. Methods We conducted case-control 21 patients who underwent because PPH between January 1, 2005 June 30, 2013, at International Peace Maternity Child Health Hospital Shanghai Jiao Tong University, School...
The widely used, risk-based Lymphome Malin de Burkitt (LMB) chemotherapy regimen has improved survival rates for children with mature B-cell non-Hodgkin lymphoma (NHL); however, associated late effects remain understudied. We assessed health outcomes after LMB treatment in the Childhood Cancer Survivor Study.Multivariable regression models compared chronic conditions, status, and socioeconomic neurocognitive between survivors of NHL treated (n = 126), non-LMB regimens 444), siblings...