A5087007852- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Reproductive Biology and Fertility
- Family Support in Illness
- Hemoglobinopathies and Related Disorders
- Neuroblastoma Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Prenatal Screening and Diagnostics
- Ethics and Legal Issues in Pediatric Healthcare
- Reproductive Health and Technologies
- Pituitary Gland Disorders and Treatments
- Renal and related cancers
- Cancer Risks and Factors
- Palliative Care and End-of-Life Issues
- Ovarian function and disorders
- Adolescent and Pediatric Healthcare
- Testicular diseases and treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Glioma Diagnosis and Treatment
- Diet and metabolism studies
- RNA modifications and cancer
Children's Healthcare of Atlanta
2015-2024
Aflac (United States)
2015-2024
Emory University
2015-2024
Children’s Institute
2024
Center for Cancer and Blood Disorders
2018-2023
Rotterdam University of Applied Sciences
2022
St. Jude Children's Research Hospital
2007-2018
Memorial Sloan Kettering Cancer Center
2007-2018
Boston Children's Hospital
2018
Vanderbilt University Medical Center
2018
To evaluate the relative contribution of modifiable cardiovascular risk factors on development major cardiac events in aging adult survivors childhood cancer.Among 10,724 5-year (median age, 33.7 years) and 3,159 siblings Childhood Cancer Survivor Study, prevalence hypertension, diabetes mellitus, dyslipidemia, obesity was determined, along with incidence severity such as coronary artery disease, heart failure, valvular arrhythmia. On longitudinal follow-up, rate ratios (RRs) subsequent...
Laron-type dwarfism is an autosomal recessive genetic disorder that characterized by high levels of growth hormone and low insulin-like factor I in the circulation. Several lines evidence suggest this disease caused a defect receptor. In order to analyze receptor gene patients with other disorders, we have first determined structure normal individuals. There are nine exons encode several additional 5' untranslated region. The coding span at least 87 kilobase pairs chromosome 5....
Childhood cancer survivors are at increased risk of morbidity and mortality. To further characterize this risk, study aimed to compare the prevalence diabetes mellitus (DM) in childhood their siblings.Participants included 8599 Cancer Survivor Study (CCSS), a retrospectively ascertained North American cohort long-term who were diagnosed between 1970 1986 as well 2936 randomly selected siblings survivors. The main outcome was self-reported DM.The mean ages 31.5 years (age range, 17.0-54.1...
Abstract Background: Childhood cancer survivors are at higher risk of morbidity and mortality from cardiovascular disease compared with the general population. Methods: Eight thousand five hundred ninety-nine (52% male) 2,936 siblings (46% Cancer Survivor Study, a retrospectively ascertained, prospectively followed study persons who survived 5 years after childhood diagnosed 1970 to 1986, were evaluated for body mass index ≥30 kg/m2 based on self-reported heights weights use medications...
Purpose To create clinically useful models that incorporate readily available demographic and cancer treatment characteristics to predict individual risk of heart failure among 5-year survivors childhood cancer. Patients Methods Survivors in the Childhood Cancer Survivor Study (CCSS) free significant cardiovascular disease 5 years after diagnosis (n = 13,060) were observed through age 40 for development (ie, requiring medications or transplantation leading death). Siblings 4,023) established...
The development of endocrinopathies in survivors childhood cancer as they age remains understudied. We characterized endocrine outcomes aging from the Childhood Cancer Survivor Study on basis therapeutic exposures.We analyzed self-reported conditions 14,290 5-year Study, with a median 6 years (range, < 1 to 20 years) at diagnosis and 32 5 58 last follow-up. Identification high-risk exposures was adopted Children's Oncology Group Long-Term Follow-Up Guidelines. Cumulative incidence curves...
We examined the rate of increase in body mass index (BMI; kg/m(2)) after final height attainment survivors acute lymphoblastic leukemia (ALL) and a noncancer comparison group.Childhood Cancer Survivor Study (CCSS) is retrospectively ascertained cohort study that prospectively tracks health status adults who were diagnosed with childhood cancer between 1970 1986 group siblings. Changes BMI from baseline enrollment to time completion follow-up (mean interval, 7.8 years) calculated for 1,451...
The majority of children, adolescents, and young adults diagnosed with cancer will become long-term survivors. Although therapy is associated many adverse effects, one the primary concerns male survivors reproductive health. Future fertility often focus concern; however, it must be recognized that all aspects health, including pubertal development, testosterone production, sexual function, can impaired by therapy. pretreatment strategies to preserve health have been beneficial some patients,...
Abstract BACKGROUND The goals of the current study were to determine distribution body mass index (BMI) survivors common pediatric malignancies and identify factors associated with abnormal BMI. METHODS Childhood Cancer Survivor Study (CCSS) is a multicenter cohort ≥ 5‐year cancer diagnosed between 1970 1986. Self‐reported heights weights used calculate BMI for 7195 adult survivors, compared population‐based, age‐specific, gender‐specific norms from 1995 National Health Interview Survey....
Cranial radiation therapy (CRT) predisposes to GH deficiency and subsequent neoplasms (SNs) of the central nervous system (CNS). Increased rates SNs have been reported in GH-treated survivors. The objective study was evaluate association between treatment development CNS-SNs. designed with a retrospective cohort longitudinal follow-up. setting multiinstitutional. A total 12 098 5-year pediatric cancer survivors from Childhood Cancer Survivor Study, diagnosed prior age 21 years, whom 338...
Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors childhood cancer. Patients Methods Participants the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for development stroke. Siblings (n 4,023) established baseline population risk. Piecewise exponential models with backward selection estimated relationships between potential predictors each outcome. The St Jude Lifetime Cohort 1,842) Emma Children’s...
Abstract Background Childhood cancer survivors have an increased risk of heart failure, ischemic disease, and stroke. They may benefit from prediction models that account for cardiotoxic treatment exposures combined with information on traditional cardiovascular factors such as hypertension, dyslipidemia, diabetes. Methods Cancer Survivor Study participants (n = 22 643) were followed through age 50 years incident Siblings 5056) served a comparator. Participants assessed longitudinally...