A5050736924- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Viral Infectious Diseases and Gene Expression in Insects
- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Pluripotent Stem Cells Research
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Breast Cancer Therapies
- Single-cell and spatial transcriptomics
- Nosocomial Infections in ICU
- Neonatal Respiratory Health Research
- Alcohol Consumption and Health Effects
- IL-33, ST2, and ILC Pathways
- Hepatitis C virus research
- DNA and Nucleic Acid Chemistry
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
Qilu Hospital of Shandong University
2025
Gannan Medical University
2025
University of California, Los Angeles
2016-2024
Anhui Medical University
2011-2024
Fifth Hospital of Shijiazhuang
2014-2024
Hebei Medical University
2022-2024
First Affiliated Hospital of Anhui Medical University
2012-2024
North China University of Science and Technology
2021
Broad Center
2019-2020
UCLA Health
2020
Childhood cancer survivors are at increased risk of morbidity and mortality. To further characterize this risk, study aimed to compare the prevalence diabetes mellitus (DM) in childhood their siblings.Participants included 8599 Cancer Survivor Study (CCSS), a retrospectively ascertained North American cohort long-term who were diagnosed between 1970 1986 as well 2936 randomly selected siblings survivors. The main outcome was self-reported DM.The mean ages 31.5 years (age range, 17.0-54.1...
Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors childhood young adult acute myeloid leukemia (AML).This analysis included 272 5-year AML who participated in Childhood Cancer Survivor Study (CCSS). All patients were diagnosed at age < or =21 years between 1970 1986, none underwent stem cell transplantation. Rates survival, relapse, outcomes analyzed.The average follow-up was 20.5 (range, 5-33 years). The overall survival rate 97%...
To construct normal values for the tests of psychometric hepatic encephalopathy score (PHES) and to evaluate its usefulness in diagnosis minimal (MHE) among Chinese individuals with cirrhosis.The five PHES, number connection test-A (NCT-A), test-B, serial dotting test, line tracing test digit symbol (DST), were administered all enrolled subjects a quiet room sufficient light. Cirrhotic overt HE excluded by West-Haven criteria detailed neurological examination. Based on nomograms healthy...
Abstract Purpose: Recent randomized trials in advanced TNBC have demonstrated improved efficacy with the addition of atezo to 1L nab-PAC patients (pts) PD-L1+ tumors (IMpassion130 [Schmid 2018]), and oral AKT inhibitor IPAT PAC, particularly pts PIK3CA/AKT1/PTEN-altered (LOTUS [Kim 2017]). Loss PTEN, a negative regulator AKT, has emerged as potential mechanism for resistance checkpoint therapy; inhibiting PI3K/AKT pathway led reversal T-cell-mediated immunotherapy [Peng 2016]. We report...
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency autoimmunity, but mechanistic basis for these outcomes incompletely understood. Here, we identify two immune lineage-dependent consequences inactivation dictated by distinct gene interactions. During T cell development, synthetically lethal downregulation dNTP triphosphohydrolase SAMHD1. This interaction requires...
Abstract Background Oral care is critical for preventing ventilator‐associated pneumonia (VAP) in intensive unit (ICU) patients. ICU nurses play a key role delivering this but often encounter challenges stemming from knowledge gaps and inconsistent practices. Aim To assess nurses' knowledge, attitudes practices (KAP) oral VAP prevention identify demographic factors influencing these variations using random forest analysis. Study Design A multi‐centre cross‐sectional study was conducted....
Abstract Background Ventilator‐associated pneumonia (VAP) is a common hospital‐acquired infection in the intensive care unit (ICU), often linked to poor oral care. Despite its importance, frequently neglected ICU settings, leading increased morbidity and health costs. Aim To explore challenges nurses face providing mechanically ventilated patients identify their specific educational needs. Study Design This study employed qualitative descriptive design detail experiences ICU. Standardized...
Generation of chimeric antigen receptor (CAR) T cells from pluripotent stem (PSCs) will enable advances in cancer immunotherapy. Understanding how CARs affect cell differentiation PSCs is important for this effort. The recently described artificial thymic organoid (ATO) system supports vitro to cells. Unexpectedly, transduced with a CD19-targeted CAR resulted diversion the innate lymphoid 2 (ILC2) lineage ATOs. and ILC2s are closely related lineages shared developmental transcriptional...
We report a serum-free, 3D murine artificial thymic organoid (M-ATO) system that mimics normal thymopoiesis with the production of all T cell stages, from early progenitors to functional single-positive (CD8SP and CD4SP) TCRαβ TCRγδ cells. RNA sequencing aligns M-ATO-derived populations phenotypically identical primary thymocytes. M-ATOs initiated Rag1
Ulcerative colitis is a gastrointestinal disorder characterized by local inflammation and impaired epithelial barrier. Previous studies demonstrated that CXC chemokine receptor 4 (CXCR4) antagonists could reduce colonic mucosal damage in dextran sulfate sodium (DSS)-induced colitis. Whether CXCR4 antagonist has action on intestinal barrier the possible mechanism, largely undefined. In present study, experimental was induced administration of 5% DSS for 7 days, AMD3100 administered...
Various mesenchymal cell types have been identified as critical components of the hematopoietic stem/progenitor (HSPC) niche. Although several groups described generation mesenchyme from human pluripotent stem cells (hPSCs), capacity such to support hematopoiesis has not reported. Here, we demonstrate that distinct subpopulations co-emerge mesoderm during hPSC differentiation. Despite co-expression common markers (CD73, CD105, CD90, and PDGFRβ), a subset defined CD146hiCD73hi expressed genes...
Standard care for preventing mother-to-child transmission (MTCT) of hepatitis B virus (HBV) in highly viremic mothers consists maternal antiviral prophylaxis beginning at gestational week 28 combined with an HBV vaccine series and immune globulin (HBIG) birth. However, HBIG is unavailable some resource-limited areas.
Current literature on cancer epidemiology typically discusses etiology of by type. Risks different types are, however, correlated at population level and may provide etiological clues. We showed previously an unexpected very high positive correlation between breast (BC) young-adult Hodgkin disease incidence rates. In a population-based case-control study BC, older ages the first Epstein-Barr virus exposure, indicated onset infectious mononucleosis, were associated with elevated BC risk. Here...
<title>Abstract</title> <bold>Background:</bold>Pancreatic stenting has been shown to effectively lower the occurrence of post-ERCP pancreatitis (PEP) and reduce its severity. To date, no evidence exists determine optimal timing for pancreatic stent placement in prospective trials. Our aim is compare early versus late preventing PEP among patients with naive papilla. <bold>Methods/Design: </bold>The<bold> </bold>EVL (Early vs. Late stenting) trial a multi-centre, single-blind, randomized,...
The thesis aims to study the subtitle translation of Song Life, a nature documentary, under guidance Eco-translatology. And it is conduct case analyses from linguistic, cultural and communicative dimensions. tries verify feasibility Eco-translatology in guiding providing new perspective for such researches accumulating more practical experience. As result, construction global ecological civilization biodiversity protection can be better promoted, making realize its value.
Abstract Genetically modified, induced pluripotent stem cells (iPSCs) offer a promising allogeneic source for the generation of functionally enhanced, chimeric antigen receptor (CAR) T cells. However, signaling CARs during early cell development and removal endogenous required to prevent alloreactivity pose significant challenges production mature conventional CAR from iPSCs. Here, we show that TCR-null, CD8αβ can be efficiently generated iPSCs by engineering stage-specific onset expression...