A5050127916- Mycorrhizal Fungi and Plant Interactions
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- High Temperature Alloys and Creep
- Forest Ecology and Biodiversity Studies
- Direction-of-Arrival Estimation Techniques
- Speech and Audio Processing
- Microstructure and Mechanical Properties of Steels
- Advancements in Transdermal Drug Delivery
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Metabolism, Diabetes, and Cancer
- Lipid Membrane Structure and Behavior
- Hydrogen embrittlement and corrosion behaviors in metals
- High-Temperature Coating Behaviors
- Isotope Analysis in Ecology
- Ecology and Vegetation Dynamics Studies
- Metallurgy and Material Forming
- Covalent Organic Framework Applications
- nanoparticles nucleation surface interactions
- Intermetallics and Advanced Alloy Properties
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Thermodynamic properties of mixtures
- Computational Drug Discovery Methods
Xuzhou Medical College
2016-2025
Jilin University
2023-2025
First Affiliated Hospital of Gannan Medical University
2022-2025
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2023-2025
Chinese Academy of Sciences
2023-2024
University of Science and Technology of China
2023-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2022-2024
Liaoning University
2019-2024
Shenyang University of Technology
2018-2022
Affiliated Hospital of Xuzhou Medical College
2016-2021
Mesenchymal stem cells (MSCs) have emerged as ideal cell-based therapeutic candidates for the structural and functional restoration of diseased kidney. Glial cell line-derived neurotrophic factor (GDNF) has been demonstrated to promote effect MSCs on ameliorating renal injury. The mechanism may involve transfer endogenous molecules via paracrine factors salvage injured cells, but these remain unknown. Methods: GDNF was transfected into human adipose mesenchymal a lentiviral transfection...
The aims of this study were to design and characterize methazolamide (MTZ)-loaded solid lipid nanoparticles (SLN) with without modification low molecular weight chitosan (CS) compare their potentials for ocular drug delivery. Low CS was obtained via a modified chemical oxidative degradation method. SLN (CS-SLN-MTZ) (SLN-MTZ) prepared according emulsion-solvent evaporation SLN-MTZ CS-SLN-MTZ 199.4 ± 2.8 nm 252.8 4.0 in particle size, −21.3 1.9 mV +31.3 1.7 zeta potential, respectively....
To successfully prepare the diclofenac sodium (DS)-loaded solid lipid nanoparticles (SLNs), phospholipid complexes (PCs) technology was applied here to improve liposolubility of DS. Solid (SLNs) loaded with were prepared by modified emulsion/solvent evaporation method. DS could be solubilized effectively in organic solvents existence and apparent partition coefficient PCs increased significantly. X-ray diffraction analysis suggested that either molecularly dispersed or an amorphous form....
Methazolamide (MTA) is an antiglaucoma drug; however, there are many side effects of its systemic administration with insufficient ocular therapeutic concentrations. The aim this study was to formulate MTA-loaded solid lipid nanoparticles (SLNs) and evaluate the potential SLNs as a new system for glaucoma. were prepared by modified emulsion–solvent evaporation method their physicochemical characteristics evaluated. pharmacodynamics investigated determining percentage decrease in intraocular...
An automated analyzer was developed to achieve fast, precise, and accurate measurements of seawater total alkalinity (AT) based on single-point titration spectrophotometric pH detection. The carried out in a circulating loop, which allowed the titrant (hydrochloric acid bromocresol green solution) sample mix at constant volume ratio. dissolved CO2 sample-titrant mixture efficiently removed by an inline remover, consists gas-permeable tubing (Teflon AF2400) submerged sodium hydroxide (NaOH)...
Combination therapy has been developed as a promising therapeutic approach for hepatocellular carcinoma therapy. Here we report low toxicity and high performance nanoparticle system that was self-assembled from poly(ethylenimine)–glycyrrhetinic acid (PEI–GA) amphiphilic copolymer versatile gene/drug dual delivery nanoplatform. PEI–GA synthesized by chemical conjugation of hydrophobic GA moieties to the hydrophilic PEI backbone via an acylation reaction. The nanocarrier could encapsulate...
The microstructure evolution of the wrought superalloy GH4698 bar subjected to annealing was investigated during solution treatment, with managing temperature and duration. differences in mechanical properties between core edge annealed rod are attributed residual stresses introduced by surface grinding shallow layers bar. Experimental findings heat treatment revealed that grains grow normally, average size exhibiting exponential growth respect time. Abnormally large (ALGs) were observed at...
Purpose: In this study, a thermosensitive in situ gelling vehicle was prepared to increase the precorneal resident time and bioavailability of methazolamide (MTA). Method: Poloxamer analogs were used as agents, gel obtained by using cold method. The gelation temperature, rheological properties, vitro release well vivo evaluation (the elimination MTA aqueous humor intraocular-lowering effect) optimized formulations investigated. Results: optimum concentrations poloxamer for gel-forming...
The present study aimed to develop and optimize chitosan coated solid lipid nanoparticles (chitosan-SLNs) encapsulated with methazolamide. Chitosan-SLNs were successfully prepared by a modified oil-in-water emulsification-solvent evaporation method glyceryl monostearate as the phospholipid surfactant. Systematic screening of formulation factors was carried out. optimized formula for preparation screened orthogonal design well Box-Behnken entrapment efficiency, particle size zeta potential...
Considering the essential role of FLT3-ITD mutations in development acute myeloid leukemia (AML), research and FLT3 inhibitors hold significant therapeutic potential. In this study, we identified a novel, highly potent small molecule inhibitor, FLIN-4, targeting through structure-based virtual screening. Notably, FLIN-4 showed exceptional inhibitory effects kinase activity inhibition assays, exhibiting effect against (IC 50 = 1.07 ± 0.04 nM). This potency was significantly superior to that...
Abstract Background Oral care is critical for preventing ventilator‐associated pneumonia (VAP) in intensive unit (ICU) patients. ICU nurses play a key role delivering this but often encounter challenges stemming from knowledge gaps and inconsistent practices. Aim To assess nurses' knowledge, attitudes practices (KAP) oral VAP prevention identify demographic factors influencing these variations using random forest analysis. Study Design A multi‐centre cross‐sectional study was conducted....
A novel strategy is presented for synthesizing isoreticular 3D COFs (JUC-300 to JUC-302) using high-coordinated building blocks as binodal tetrahedral nodes, enabling tunable pore sizes (1.6–5.2 nm) and a non-interpenetrated pcu -derived dia topology.
An increased risk of colorectal cancer is related to the development metabolic syndromes including hyperglycemia, and hyperinsulinemia. The high circulatory levels glucose and/or insulin or application exogenous may promote carcinogenesis, progression metastasis, which can be attributed Warburg effect aerobic glycolysis. We attempted resolve these existing questions by applying analog 2-deoxyglucose (2DG). According in vitro studies we performed, glycolysis cells could interrupted 2DG as it...
This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages diabetic nephropathy (DN) vivo and evaluating mechanism high glucose (HG)-treated renal tubular epithelial cells (RTECs) vitro. Sprague-Dawley (SD) rats were used to establish a model DN, changes biochemical indicators body weight measured. The degree was quantified using histological analysis, immunohistochemistry, immunoblot. underlying relationship between autophagy cellular...