A5101766067- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Liver physiology and pathology
- Dendrimers and Hyperbranched Polymers
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Inhalation and Respiratory Drug Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Mesoporous Materials and Catalysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Endoplasmic Reticulum Stress and Disease
China Pharmaceutical University
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2025
Chongqing Medical University
2014-2025
Chinese PLA General Hospital
2025
Yanbian University
2023
Shandong Tumor Hospital
2023
Shandong First Medical University
2023
Xinjiang Medical University
2019-2021
First Hospital of Jilin University
2020-2021
Jilin University
2020-2021
Abstract Background Increasing studies have shown that circRNA is closely related to the carcinogenesis and development of many cancers. However, biological functions underlying molecular mechanism circRNAs in triple-negative breast cancer (TNBC) remain largely unclear so far. Methods Here, we investigated expression pattern four pairs TNBC tissues paracancerous normal using RNA-sequencing. The prognostic significance circSEPT9 were evaluated with qRT-PCR situ hybridization two cohorts....
In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement initiation progression diverse kinds human diseases, especially cancer. However, regulatory role, clinical significance underlying mechanisms circRNAs in triple-negative breast cancer (TNBC) still remain largely unknown.Here, the expression profile 4 pairs TNBC tissues adjacent non-tumor was analyzed by RNA-sequencing. Quantitative real-time...
Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs stored in the mesopores under a physiological environment. Upon H+ stimulus endosomal and lysosomal compartments, released into intracellular organelles of cancer cells, effectively killing cells. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
Abstract Background Hypoxia has long been considered as a hallmark of solid tumors and is closely associated with tumor progression. Circular RNAs (circRNAs) have identified critical modulator in various cancers. However, the connections between hypoxia circRNAs are largely unknown. Methods Here, we investigated expression profile breast cancer (BC) MCF-7 cells under normoxia using microarray. We novel hypoxia-responsive circRNA named circWSB1, whose pattern, potential diagnostic value...
During liver fibrogenesis, the reciprocal crosstalk among capillarized sinusoidal endothelial cells (LSECs), activated hepatic stellate (HSCs), and dysfunctional hepatocytes constructs a self-amplifying vicious cycle, greatly exacerbating disease condition weakening therapeutic effect. Limited by malignant cellular interactions, previous single-cell centric treatment approaches show unsatisfactory efficacy fail to meet clinical demand. Herein, cycle-breaking strategy is proposed target...
Abstract Oxygen plays an essential role in the photodynamic therapy (PDT) of cancer. However, hypoxia inside tumors severely attenuates therapeutic effect PDT. To address this issue, a novel strategy is reported for cutting off oxygen consumption pathway by using sub‐50 nm dual‐drug nanoparticles (NPs) to attenuate hypoxia‐induced resistance PDT and enhance efficiency. Specifically, NPs that encapsulate photosensitizer (PS) verteporfin (VER) oxygen‐regulator atovaquone (ATO) with diameters...
In this study, a dual-targeting drug delivery system based on bovine serum albumin nanoparticles (BSA-NPs) modified with both lactoferrin (Lf) and mPEG2000 loading doxorubicin (DOX) was designed, its blood–brain barrier (BBB) penetration brain glioma cells targeting properties were explored. BSA-NPs prepared by desolvation technique, incorporated onto the surface of reacting free amino-group BSA to form mPEG2000-modified (P2000-NPs). Finally, Lf-modified P2000-NPs (Lf-NPs) obtained absorbing...
Abstract Background Recent studies have revealed that circular RNAs (circRNAs) play significant roles in the occurrence and development of many kinds cancers including breast cancer (BC). However, potential functions most circRNAs molecular mechanisms underlying progression BC remain elusive. Method Here, Circular RNA microarray was executed 4 pairs tissues para-cancer tissues. The expression prognostic significance circACTN4 cells were determined by qRT-PCR situ hybridization. Gain-and...
During liver fibrogenesis, sinusoidal capillarization and extracellular matrix (ECM) deposition construct dual pathological barriers to drug delivery. Upon capillarization, the vanished fenestrae in endothelial cells (LSECs) significantly hinder substance exchange between blood cells, while excessive ECM further hinders delivery of nanocarriers activated hepatic stellate (HSCs). Herein, an efficient nanodrug system was constructed sequentially break through capillarized LSEC barrier...
Abstract Non-small cell lung cancer (NSCLC) shows high drug resistance and leads to low survival due the level of mutated Tumor Protein p53 ( TP53 ). Cisplatin is a first-line treatment option for NSCLC, mutation major factor in chemoresistance. We demonstrate that cisplatin chemotherapy increases risk mutations, further contributing resistance. Encouragingly, we find combination fluvastatin can alleviate this problem. Therefore, synthesize Fluplatin, prodrug consisting fluvastatin. Then,...
Abstract Pancreatic fibrosis (PF) is primarily characterized by aberrant production and degradation modes of extracellular matrix (ECM) components, resulting from the activation pancreatic stellate cells (PSCs) pathological cross‐linking ECM mediated lysyl oxidase (LOX) family members. The excessively deposited increases stiffness, over‐accumulated reactive oxygen species (ROS) induces oxidative stress, which further stimulates continuous PSCs advancing PF; challenging strategy toward...
Abstract Capturing circulating tumor cells (CTCs) in vivo from the bloodstream lessens metastasis and recurrence risks. However, absence of CTC receptors due to epithelial‐mesenchymal transition (EMT), limited binding capacity a single ligand, complexity blood flow environment significantly reduce efficiency capture vivo. Herein, multivalent ligand‐decorated microsphere enrichment system (MLMES) is crafted that incorporates column replete with an immunosorbent precisely recognizes binds...
Multidrug resistance (MDR) greatly impedes the therapeutic efficacy of chemotherapeutic agents. Overexpression ATP-binding cassette (ABC) transporters, such as P-gp, on surface tumor cells is a major mechanism in MDR. In this study, we fabricated manganese dioxide (MnO2)/doxorubicin (DOX)-loaded albumin nanoparticles (BMDN) for magnetic resonance imaging and reversing MDR resistant tumor. BMDN facilitated delivery DOX into through their reversal effects including enhanced cellular uptake,...