A5100442526- Cancer-related molecular mechanisms research
- Oral microbiology and periodontitis research
- Complement system in diseases
- Platelet Disorders and Treatments
- Plant Gene Expression Analysis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Light effects on plants
- Immune Response and Inflammation
- Inflammasome and immune disorders
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Cancer-related gene regulation
- Atherosclerosis and Cardiovascular Diseases
- Gout, Hyperuricemia, Uric Acid
- Galectins and Cancer Biology
- Immune cells in cancer
- HIV Research and Treatment
- Heat shock proteins research
- SARS-CoV-2 and COVID-19 Research
- Biological Research and Disease Studies
- Chemokine receptors and signaling
- Dental Health and Care Utilization
- Cardiovascular Issues in Pregnancy
- Ferroptosis and cancer prognosis
Chongqing Medical University
2019-2025
Sichuan Agricultural University
2025
First People's Hospital of Chongqing
2025
Chongqing University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2023
First Affiliated Hospital of Fujian Medical University
2021-2023
Fujian Medical University
2021-2023
Daping Hospital
2022
Army Medical University
2022
Johns Hopkins University
2019-2020
Abstract Background Hypoxia has long been considered as a hallmark of solid tumors and is closely associated with tumor progression. Circular RNAs (circRNAs) have identified critical modulator in various cancers. However, the connections between hypoxia circRNAs are largely unknown. Methods Here, we investigated expression profile breast cancer (BC) MCF-7 cells under normoxia using microarray. We novel hypoxia-responsive circRNA named circWSB1, whose pattern, potential diagnostic value...
Abstract Background Breast cancer (BC) is a common malignant tumor in women worldwide. Circular RNA (circRNA) has been proven to play critical role BC progression. However, the exact biological functions and underlying mechanisms of circRNAs remain largely unknown. Methods Here, we first screened for differentially expressed 4 pairs tissues adjacent non-tumor using circRNA microarray. Functionally, gain- loss-of-function experiments vitro vivo showed that circDNAJC11 promoted cell...
Abstract Aim This Mendelian randomization (MR) study was performed to explore the potential bidirectional causal relationship between gut microbiome (GM) and periodontitis. Materials Methods We used genetic instruments from genome‐wide association of European descent for periodontitis GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium (17,353 cases 28,210 controls) FinnGen (4434 259,234 investigate with GM (the MiBioGen consortium, 18,340 samples), vice versa. Several MR...
Introduction Arthrinium phaeospermum can cause large areas wilted and death of Bambusa pervariabilis × Dendrocalamopsis grandis , resulting in serious ecological economic losses. Previous studies found that the appressorium A. must form to invade host cells disease. A short-chain dehydrogenase/reductase gene has been shown maintain osmotic pressure by synthesizing fungal melanin penetrate plant epidermis The SDR family was be highly expressed during penetration transcriptome sequencing...
Atherosclerosis is a significant contributor to cardiovascular disease, and conventional diagnostic methods frequently fall short in the timely accurate detection of early-stage atherosclerosis. Abnormal lipid metabolism plays critical role development Consequently, identification new markers essential for precise diagnosis this condition. The datasets related atherosclerosis utilized research were obtained from GEO database (GSE2470, GSE24495, GSE100927 GSE43292). ssGSEA technique was first...
Published studies proved that both pyroptosis and periodontitis owned a substantial relationship with immunity, recent research revealed solid correlation between pyroptosis. While abundant findings have confirmed has strong impact on the tumor microenvironment, function of in influencing immune microenvironment remains poorly understood. Thus, we aimed to identify pyroptosis-related genes whose expression signature can well discriminate from healthy controls comprehend role...
To identify the value of radiomics method derived from CT images to predict prognosis in patients with COVID-19.A total 40 COVID-19 were enrolled study. Baseline clinical data, images, and laboratory testing results collected all patients. We defined that ROIs absorption group decreased density scope GGO, progress progressed consolidation. A 180 (n = 118) consolidation 62) randomly divided into a training set 145) validation 35) (8:2). Radiomics features extracted radiomics-based models...
Background Periodontitis (PD), an age-related disease, is characterized by inflammatory periodontal tissue loss, and with the general aging of global population, burden PD becoming a major health concern. Nevertheless, mechanism underlying this phenomenon remains indistinct. We aimed to develop classification model for explore relationship between subtypes immune microenvironment based on bioinformatics analysis. Materials Methods The PD-related datasets were acquired from Gene Expression...
This study aims to investigate the differences in epigenomic patterns of N6-methyladenosine (m6A) methylation gingival tissues between patients with periodontitis (PD) and healthy controls, identifying potential biomarkers.As a multifactorial disease, PD involves multiple genetic environmental effects. The m6A modification is most prevalent internal mRNA linked various inflammatory diseases. However, pattern m6A-related signatures remain unclear.An microarray human was conducted eight...
Introduction: Immune microenvironment and microRNAs serve as common predictors for diagnosis prognosis of tumors. Methods: Expression 122 genes 126 in thymoma was obtained from TCGA database. The proportion tumor-infiltrating cells calculated, IMRS constructed. TREM2hi score calculated before functional enrichment analysis on gene sets. Results: IMRS3, score, CD8+ T lymphocyte abundance were significantly different among WHO classifications. classification, Masaoka staging, miR-130b-5p,...
Abstract Background and Objectives Periodontitis, a prevalent chronic inflammatory condition, poses significant risk of tooth loosening subsequent loss. Within the realm programmed cell death, recently recognized process known as necroptosis has garnered attention for its involvement in numerous diseases. Nevertheless, correlation with periodontitis is indistinct. Our study aimed to identify necroptosis‐related lncRNAs crucial lncRNA‐miRNA‐mRNA regulatory axes further understand pathogenesis...
This study aimed to identify potential biomarkers for prostate cancer (PCa) progression and metastasis, discern their biological functions.Bioinformatics methods were used screen hub genes. The expression level of key genes in PCa was determined prognostic significance examined. A series functional assays performed investigate the function highest-ranking gene.Actin related protein 2/3 complex subunit 1A (ARPC1A) identified as gene. ARPC1A highly expressed tissues cell lines, an independent...
Abstract Objective This study aimed to investigate the effect of METTL3 knockdown on osteogenic differentiation human periodontal ligament stem cells (PDLSCs) in weak inflammation microenvironments, as well underlying mechanisms. Materials and Methods PDLSCs were stimulated by lipopolysaccharide from Escherichia coli ( E. LPS), followed quantification METTL3. expression was assessed using RT‐qPCR Western blot analysis periodontitis. with or without LPS. The evaluation included...
Pheochromocytoma and paraganglioma (PCPG) is a rare neuroendocrine tumor. This study aims to identify vital prognostic genes which were associated with PCPG tumor microenvironment (TME). We downloaded transcriptome data of from TCGA database calculated the immune scores stromal by using ESTIMATE algorithm. DEGs related TMB then identified. conducted WGCNA further extract TME-related modules. GO, KEGG pathway analysis, PPI network performed. Survival analysis was hub prognosis PCPG. A total...