A5078644299- Pneumonia and Respiratory Infections
- Plant Virus Research Studies
- Insect symbiosis and bacterial influences
- Bacterial Infections and Vaccines
- Immune Response and Inflammation
- Insect-Plant Interactions and Control
- Ear Surgery and Otitis Media
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Cancer-related gene regulation
- Asthma and respiratory diseases
- Bioactive natural compounds
- RNA modifications and cancer
- Insect Resistance and Genetics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Streptococcal Infections and Treatments
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Mosquito-borne diseases and control
- Plant Parasitism and Resistance
- Neonatal and Maternal Infections
- dental development and anomalies
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
Shaanxi University of Science and Technology
2025
Ningbo University
2019-2025
Chongqing Medical University
2014-2023
Nanjing Agricultural University
2021-2022
Second People’s Hospital of Huai’an
2021
Xuzhou Medical College
2021
ZheJiang Academy of Agricultural Sciences
2019
Children's Hospital of Chongqing Medical University
2010-2019
Wuhan University of Science and Technology
2017
The Ohio State University
2011-2014
Abstract Salivary elicitors secreted by herbivorous insects can be perceived host plants to trigger plant immunity. However, how secrete other salivary components subsequently attenuate the elicitor-induced immunity remains poorly understood. Here, we study small brown planthopper, Laodelphax striatellus sheath protein LsSP1. Using Y2H, BiFC and LUC assays, show that LsSP1 is into binds via mucin-like (LsMLP). Rice pre-infested with ds LsSP1- treated L. are less attractive nymphs than those...
Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait, which widely used to treat diseases such as viral hepatitis, cardiac arrhythmia and skin inflammations. As indicated by previous reports, molecular mechanism matrine's anti-cancer effect has been poorly clarified. In this study, we both in vitro vivo models investigate antitumor its possible mechanisms. Murine hepatocellular carcinoma H22 cells were cultured presence matrine at various concentrations (0.2...
Abstract Background: Increased cell-free DNA (cf-DNA) and the integrity of cf-DNA in plasma patients with cancer has been described. We investigated clinical utility detection monitoring progression leukemia. Methods: Plasma samples from 60 acute leukemia were analyzed comparison to 30 healthy controls. was determined by quantitative PCR (qPCR) amplifying β-actin gene ( ACTB ). The index calculated as ratio qPCR results 384/106). Paired diagnostic/complete remission (CR)/relapse eight...
Abstract A large number of insect-specific viruses (ISVs) have recently been discovered, mostly from hematophagous insect vectors because their medical importance, but little attention has paid to important plant virus such as the whitefly Bemisia tabaci , which exists a complex cryptic species. Public SRA datasets B. and newly generated transcriptomes three Chinese populations are here comprehensively investigated characterize viromes different Twenty novel ISVs were confidently identified,...
Abstract Aim This Mendelian randomization (MR) study was performed to explore the potential bidirectional causal relationship between gut microbiome (GM) and periodontitis. Materials Methods We used genetic instruments from genome‐wide association of European descent for periodontitis GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium (17,353 cases 28,210 controls) FinnGen (4434 259,234 investigate with GM (the MiBioGen consortium, 18,340 samples), vice versa. Several MR...
Abstract The utilization of plant‐derived exosome‐like nanovesicles (ELNs) as nanocarriers for oral delivery bioactives has garnered significant attention. However, their distinctive lipid membrane composition may result in elevated permeability within the gastrointestinal environment, leading to leakage carried bioactives. Inspired by concept projectile design, Tartary buckwheat‐derived ELNs (TB‐ELNs) based dual‐carriers are fabricated loading chlorogenic acid (CGA) into cores and bonding...
ABSTRACT Many plant viruses are persistently transmitted by insect vectors. The viral antagonism of innate immune responses is a critical step in ensuring persistent infection. Recent studies have shown that the Toll pathway mediates and propagative transmission rice stripe virus (RSV) its vector ( Laodelphax striatellus ). However, whether other host factors involved how RSV counteracts response L. remain unclear. Here, we reported LsPellino also inhibited infection interacting with LsTube...
Dental follicle stem cells are a group of possessing osteogenic, adipogenetic and neurogenic differentiations, but the specific mechanism underlying multilineage differentiation remains still unclear.Great attention has been paid to bone morphogenetic protein-9 (BMP-9) due its potent osteogenic activity.In present study, rat dental were isolated purified, passage 3 underwent adenovirus mediated BMP-9 gene transfection prepare with stable expression.Detection alkaline phosphatase (ALP)...
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Interaction between virulence factors of streptococcus pneumoniae and innate immune receptors elicits host responses through specific signaling pathways during infection. Insights into the events may provide a better knowledge starting for host-pathogen interaction. Here we demonstrated significant induction response elicited by recombinant endopeptidase O (rPepO), newer pneumococcal protein, both in vivo vitro. Intratracheal instillation rPepO protein resulted increase cytokines production...
Published studies proved that both pyroptosis and periodontitis owned a substantial relationship with immunity, recent research revealed solid correlation between pyroptosis. While abundant findings have confirmed has strong impact on the tumor microenvironment, function of in influencing immune microenvironment remains poorly understood. Thus, we aimed to identify pyroptosis-related genes whose expression signature can well discriminate from healthy controls comprehend role...
Pneumococcal polysaccharide-based vaccines are effective in preventing pneumococcus infection; however, some drawbacks preclude their widespread use developing and undeveloped countries. Here, we evaluated the protective effects of ATP-dependent caseinolytic protease (ClpP), pneumolysin mutant (DeltaA146 Ply), putative lipoate-protein ligase (Lpl), or combinations thereof against pneumococcal infections mice. Vaccinated mice were intraperitoneally and/or intranasally challenged with...
ABSTRACT Streptococcus pneumoniae is a Gram-positive and human-restricted pathogen colonizing the nasopharynx with an absence of clinical symptoms as well major causing otitis media (OM), one most common childhood infections. Upon bacterial infection, neutrophils are rapidly activated recruited to infected site, acting frontline defender against emerging microbial pathogens via different ways. Evidence shows that interleukin 17A (IL-17A), neutrophil-inducing factor, plays important roles in...
The Toll pathway plays an important role in defense against infection of various pathogenic microorganisms, including viruses. However, current understanding was mainly restricted mammal and some model insects such as Drosophila mosquitoes. Whether plant viruses can also activate the signaling vector is still unknown. In this study, using rice stripe virus (RSV) its insect (small brown planthopper, Laodelphax striatellus ) a model, we found that activated upon RSV infection. comparison...
Throughout evolution, arboviruses have developed various strategies to counteract the host’s innate immune defenses maintain persistent transmission. Recent studies shown that, in addition bacteria and fungi, Toll-Dorsal system also plays an essential role preventing viral infections invertebrates. However, whether classical Toll pathway is involved maintaining homeostatic process ensure propagative transmission of insect vectors remain unclear. In this study, we revealed that transcription...
We recently reported that the complement system plays a pivotal role in innate immune defense against Streptococcus pneumoniae during acute otitis media (OM) mice. The current study was designed to determine which of pathways are activated pneumococcal OM and whether components expressed middle ear epithelium. Gene expression determined by quantitative PCR, enzyme-linked immunosorbent assay (ELISA), immunofluorescence staining. found S. induced increased gene factor B alternative pathway C3...
Summary Airway inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and asthma are associated with elevated expression of interleukin‐32 (IL‐32), a recently described cytokine that appears to play critical role in inflammation. However, so far, the regulation IL‐32 production has not been fully established. We examined by tumour necrosis factor‐ α (TNF‐ ) primary human lung fibroblasts. Human fibroblasts were cultured presence or absence TNF‐ and/or other...
Negeviruses are a proposed group of insect-specific viruses that can be separated into two distinct phylogenetic clades, Nelorpivirus and Sandewavirus. well-known for their wide geographic distribution broad host range among hematophagous insects. In this study, the full genomes novel negeviruses from each these clades were identified by RNA extraction sequencing single dungfly (Scathophaga furcata) collected Arctic Yellow River Station, where first cold zone regions to discovered. dungfly1...
Zoonoses are diseases and infections naturally transmitted between humans vertebrate animals. They form the dominant group of among emerging infectious represent critical threats to global health security. This dilemma is largely attributed our insufficient knowledge pathogenesis regarding zoonotic spillover. Long non-coding RNAs (lncRNAs) transcripts with limited coding capacity. Recent technological advancements have enabled identification numerous lncRNAs in humans, animals, even...
The advancement of bioinformatics and sequencing technology has resulted in the identification an increasing number new RNA viruses. This study systematically identified virome willow-carrot aphid, Cavariella aegopodii (Hemiptera: Aphididae), using metagenomic rapid amplification cDNA ends (RACE) approaches. C. is a sap-sucking insect widely distributed Europe, Asia, North America, Australia. deleterious effects on crop growth primarily stem from its feeding activities role as vector for...
Zinc metalloprotease B (ZmpB) is present in all isolated pneumococcal strains and contributes to the pathogenesis of infection. In this study, recombinant ZmpB was cloned expressed Escherichia coli. The expression by different detectable Western blotting with antisera raised ZmpB. Flow cytometry analysis demonstrated that anti-ZmpB polyclonal antibodies could bind cell surface analyzed. Both protein significantly inhibited adhesion Streptococcus pneumoniae D39 A549 cells. mouse models,...