A5101819624- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Response and Inflammation
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Pediatric health and respiratory diseases
- Streptococcal Infections and Treatments
- Orthopedic Infections and Treatments
Chongqing Medical University
2011-2020
Affiliated Hospital of Zunyi Medical College
2016
Children's Hospital of Chongqing Medical University
2016
Ministry of Education of the People's Republic of China
2012
To investigate the molecular epidemiology of pneumococcal isolates in Chongqing, China.In this cross-sectional study, 51 invasive Streptococcus pneumoniae (S. pneumoniae) strains were from children with disease (IPD) and 32 carriage healthy January 2010 to December 2013 at Children's Hospital Chongqing Medical University, China. Multilocus sequence typing was used identify types (STs). Capsular serotypes determined by multiplex polymerase chain reaction. Drug susceptibility resistance...
Streptococcus pneumoniae resides on the mucosal surface of upper respiratory tract and is ready to spread trigger clinical diseases. Hence vaccine that can eliminate nasopharyngeal colonization was thought be an ideal protective strategy against pneumococcal invasive Caseinolytic protease X (ClpX), a caseinolytic ATPase subunit, shown non-transmembrane protein by bioinformatics analysis. Consistent with in silico prediction, secretory expression ClpX, instead exposure, further confirmed flow...
Pneumolysin (Ply) is a major virulence factor of Streptococcus pneumoniae. Ply-induced interferon-β (IFN-β) expression in host macrophages has been shown to be due the accumulation mitochondrial deoxyribonucleic acid (mtDNA) cytoplasm during S. pneumoniae infection. Our findings extend this work show human bronchial epithelial cells that reside at interface inflammatory injury, BEAS-2B, adapt local cues by altering states and releasing excess mtDNA. The results research showed purified Ply...