Abstract The COVID-19 is currently spreading around the world, which has posed significant threats to global health and economy. Convalescent plasma confirmed effective against novel corona virus in preliminary studies. In this paper, we first described therapeutic schedule, antibody detection method, indications, contraindications of convalescent plasmas, reported operability treatment by case study.

In recent years, the hemoglobin, albumin, lymphocyte, and platelet (HALP) score has emerged as a potential marker of immunological nutritional status. This study aimed to evaluate association between HALP prognosis in patients with sepsis. retrospective cohort analyzed sepsis using clinical data from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients were classified into Low-score High-score groups. Confounding factors controlled through propensity matching (PSM)...

Abstract We aimed to explore the association between FFP transfusion and outcomes of DC patients with significant coagulopathy. A total 693 coagulopathy were analyzed 233 per group after propensity score matching (PSM). Patients who received matched those receiving conventional therapy via PSM. Regression analysis showed had no benefit in 30-day (HR: 1.08, 95% CI 0.83–1.4), 90-day 1.03, 0.80–1.31) in-hospital(HR: 1.30, 0.90–1.89) mortality, associated increased risk liver failure (OR: 3.00,...

Multidrug-resistant staphylococcus aureus infected wounds can lead to nonhealing, systemic infections, and even death. Although advanced dressings are effective in protecting, disinfecting, maintaining moist microenvironments, they often have limitations such as single functionality, inadequate drug release, poor biosafety, or high rates of resistance.Here, a novel wound dressing comprising glycyrrhizic acid (GA) tryptophan-sorbitol carbon quantum dots (WS-CQDs) was developed, which exhibit...

Abstract Background Serum calcium levels disorder have been reported to be associated with poor prognosis in different diseases. Studies on the association between serum and outcomes of septic patients remained limited. The aim this study is investigate 28-day mortality patients. Method Patients diagnosed sepsis Medical Information Mart for Intensive Care III database were included. divided into five groups according quintiles levels, their baseline characteristics compared. Multivariate Cox...

Zinc metalloprotease B (ZmpB) is present in all isolated pneumococcal strains and contributes to the pathogenesis of infection. In this study, recombinant ZmpB was cloned expressed Escherichia coli. The expression by different detectable Western blotting with antisera raised ZmpB. Flow cytometry analysis demonstrated that anti-ZmpB polyclonal antibodies could bind cell surface analyzed. Both protein significantly inhibited adhesion Streptococcus pneumoniae D39 A549 cells. mouse models,...

Previous studies have already established that low platelet count is related to adverse outcomes in patients with type A acute aortic dissection (AAAD). However, there are yet limited investigating the association of and risk postoperative pneumonia AAAD patients.This retrospective cohort study was conducted Xiangya Hospital Central South University from January 2014 May 2019. Clinical laboratory data were collected. The correlation between analyzed using multivariate logistic regression...

ABSTRACT Background: Despite advancements in sepsis treatment, mortality remains high. Plasmapheresis (PE) targeting multiple pathways simultaneously seems to be a potential treatment option, but evidence is insufficient. We aimed investigate the efficacy of PE for with organ failure (MOF). Method: Septic patients MOF were identified from Medical Information Mart Intensive Care IV database. Patients who received matched those receiving conventional therapy via propensity score matching....

The recent outbreak of COVID-19 in the world is currently a big threat to global health and economy. Convalescent plasma has been confirmed effective against novel corona virus preliminary studies. In this paper, we first described therapeutic schedule, antibody detection method, indications, contraindications convalescent plasmas reported effectiveness therapy by retrospective cohort study.

Abstract Background The platelet-lymphocyte ratio (PLR), a novel inflammatory marker, is generally associated with increased in-hospital mortality risk. We aimed to investigate the association between PLR and postoperative risk in patients type A acute aortic dissection (AAAD). Methods Patients (n = 270) who underwent emergency surgery for AAAD at Xiangya Hospital of Central South University January 2014 May 2019 were divided into three PLR-based tertiles. used multiple regression analyses...

Anemia is a common complication of hepatitis B-related acute-on-chronic liver failure (HB-ACLF). Eryptosis, suicidal erythrocyte death characterized by phosphatidylserine (PS) externalization and red blood cell-derived microparticle (RMP) generation, decreases lifespan. Herein, we investigated whether enhanced eryptosis involved in the anemia pathophysiology associated with HB-ACLF. PS exposure, cell volume, cytosolic Ca2+, reactive oxygen species (ROS) production were determined using flow...

Abstract We aimed to establish a predictive model assessing perioperative blood transfusion risk using nomogram. Clinical data for 97,443 surgery patients were abstracted from the DATADRYAD website; approximately 75% of these enrolled in derivation cohort, while 25% validation cohort. Multivariate logical regression was used identify factors transfusion. Receiver operating characteristic (ROC) curves, calibration plots, and decision curves assess performance. In total, 5888 received > 1...

Background Blood transfusion is a frequent and necessary practice in acute type A aortic dissection (AAAD) patients, but the effect of plasma/red blood cells (RBCs) ratio on mortality remains unclear. The aim this study to investigate association between plasma/RBCs in-hospital patients with AAAD. Methods Patients were admitted Xiangya Hospital Central South University from January 1, 2016 December 31, 2021. Clinical parameters recorded. Multivariate Cox regression model was used analyze...

To assess the serotype distribution and antimicrobial susceptibility of pneumococci isolated from inpatients all ages suspected having bacterial infections.In this retrospective study, pneumococcal isolates were consecutively collected Third Affiliated Hospital Zunyi Medical University, in city, China, between January 2014 December 2016. Pneumococci identified using routine microbiological assays. We performed analyses bacteria identification/susceptibility system VITEK2 E-tests. Capsular...

Given the high incidence and mortality rate of sepsis, early identification high-risk patients timely intervention are crucial. However, existing risk prediction models still have shortcomings in terms operation, applicability, evaluation on long-term prognosis. This study aims to investigate factors for death with construct model short-term risk.

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), has rapidly spread throughout China and worldwide. Little is known about dynamic changes in patient immune responses to SARS-CoV-2 how different are correlated with severity outcomes. Seventy-four patients confirmed COVID-19 were enrolled this prospective research. demographic information, medical history, symptoms, signs laboratory results analyzed compared between non-severe patients....

Background Platelet distribution width (PDW), as a widely applied and reliable marker of platelet activation, was associated with adverse outcomes in cardiovascular diseases. However, there is little literature on the relationship between PDW postoperative pneumonia patients type A acute aortic dissection (AAAD). Methods In this retrospective cohort study, we collected consecutive who underwent emergency surgery for AAAD at Xiangya Hospital Central South University from January 1, 2014 June...

：Objective To analyze the diagnostic value of 4 serumautoantibodies in nasopharyngeal carcinoma patients (anti-Rho-GDI-2, -HSP70, -CK19 and-LAP3 antibodies) using a serological proteomic approach. Methods The conditions forblocking, antigen concentrations and serum dilution were optimized to establish ELISAmethod for detection autoantibodies Rho-GDI-2, HSP70, CK19 LAP3. Theserum these detected by established method 36NPC patients, 20 other cancer healthy individuals. statisticalanalysis was...

Abstract Background COVID-19 elicits a range of different responses in patients and can manifest into mild to very severe cases individuals, depending on many factors. We aimed establish prediction model risk patients, help clinicians achieve early prevention, intervention, aid them choosing effective therapeutic strategy. Methods selected confirmed who admitted First Hospital Changsha city between January 29 February 15, 2020 collected their clinical data. Multivariate logical regression...

Abstract Coronavirus disease-2019 (COVID-19) elicits a range of different responses in patients and can manifest into mild to very severe cases individuals, depending on many factors. We aimed establish prediction model risk COVID-19 patients, help clinicians achieve early prevention, intervention aid them choosing effective therapeutic strategy. selected confirmed who were admitted First Hospital Changsha city between 29 January 15 February 2020 collected their clinical data. Multivariate...