A5009762529- Erythrocyte Function and Pathophysiology
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Blood groups and transfusion
- Pancreatitis Pathology and Treatment
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- Ion channel regulation and function
- Gut microbiota and health
- Cannabis and Cannabinoid Research
- Renal function and acid-base balance
- Liver Disease and Transplantation
- Cholesterol and Lipid Metabolism
- Hepatitis C virus research
- Hemoglobin structure and function
- Blood properties and coagulation
- Hepatitis Viruses Studies and Epidemiology
- Immune cells in cancer
Xiangya Hospital Central South University
2020-2025
Central South University
2020-2025
Abstract Hemolytic anemia (HA) is characterized by massive destruction of red blood cells (RBCs) and insufficient oxygen supply, which can lead to shock, organ failure, even death. Recent studies have preliminarily demonstrated the therapeutic effectiveness whole exchange (WBE) in management acute hemolytic exhibited potential for reducing duration corticosteroid treatment, while underlying mechanism WBE therapy was not investigated preclinical study. Hence, we investigate mechanisms HA...
Abstract Background Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein (VCP) a member AAA-ATPase family associated with multiple molecular functions and involved in tumor metastasis prognosis. However, role VCP HCC progression still unclear. Methods We examined expression using RNA sequencing microarray data from public databases measured it clinical samples cell lines by western blot, immunohistochemistry (IHC). also evaluated...
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. NAFLD encompasses a spectrum damage starting with steatosis and lipid disorders presented as hallmark. Cannabinoid-2 receptor (CB2R) endocannabinoids mainly expressed in immune cells. Our preliminary study revealed preventative role CB2R injury related to metabolism. In this study, we aimed explore underlying mechanism microbial community. High-fat diet-induced model was established mice. We found...
BACKGROUND Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with poor prognosis, which often associated chronic hepatitis B virus infection in China. Our previous study has shown that long non-coding RNA semaphorin 6A-antisense 1 (SEMA6A-AS1) was significantly downregulated virus-related HCC and prognosis. AIM To explore the underlying mechanism of SEMA6A-AS1 progression. METHODS The expression levels SEMA6A were detected using quantitative polymerase chain reaction,...
Abstract We aimed to explore the association between FFP transfusion and outcomes of DC patients with significant coagulopathy. A total 693 coagulopathy were analyzed 233 per group after propensity score matching (PSM). Patients who received matched those receiving conventional therapy via PSM. Regression analysis showed had no benefit in 30-day (HR: 1.08, 95% CI 0.83–1.4), 90-day 1.03, 0.80–1.31) in-hospital(HR: 1.30, 0.90–1.89) mortality, associated increased risk liver failure (OR: 3.00,...
Abstract Background Serum calcium levels disorder have been reported to be associated with poor prognosis in different diseases. Studies on the association between serum and outcomes of septic patients remained limited. The aim this study is investigate 28-day mortality patients. Method Patients diagnosed sepsis Medical Information Mart for Intensive Care III database were included. divided into five groups according quintiles levels, their baseline characteristics compared. Multivariate Cox...
ABSTRACT Background: Despite advancements in sepsis treatment, mortality remains high. Plasmapheresis (PE) targeting multiple pathways simultaneously seems to be a potential treatment option, but evidence is insufficient. We aimed investigate the efficacy of PE for with organ failure (MOF). Method: Septic patients MOF were identified from Medical Information Mart Intensive Care IV database. Patients who received matched those receiving conventional therapy via propensity score matching....
Liver fibrosis is a major global healths problem; nevertheless, its molecular mechanism are not completely clear. This study aimed to build lncRNA-miRNA-mRNA network, identify potentially related lncRNAs, and explore the pathogenesis of liver fibrosis. We used Gene Expression Omnibus databases bioinformatics analysis differentially expressed genes (DEGs) between normal tissues. The ceRNA network was constructed according interactions DElncRNA, miRNA, DEmRNA. Then, these DEGs were identified...
Blood exchange therapy, specifically Whole blood (WBE), is increasingly being utilized in clinical settings to effectively treat a range of diseases. Consequently, there an urgent requirement establish convenient and clinically applicable animal models that can facilitate the exploration therapy mechanisms. Our study conducted continuous WBE rats through femoral tail vein catheterization using dual-directional syringe pumps. To demonstrate applicability WBE, drug-induced hemolytic anemia...
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by high-grade inflammation and multi-organ failure. Our previous study shows that targeting the M2 isoform of pyruvate kinase (PKM2) to inhibit macrophage may be promising strategy for ALF treatment. however, mechanism which PKM2 regulates inflammatory response unclear. Here we demonstrate contributes modulating NLRP3-mediated pyroptosis activation in macrophages. The specific knockout myeloid cells reduces...
Tenofovir alafenamide (TAF) is one of the most potent first-line nucleot(s)ide analogs for treating chronic hepatitis B virus (HBV) infections. To date, no cases TAF drug resistance and/or suboptimal response have been reported. our knowledge, this first report two adult male patients presenting a to monotherapy. Our study indicates long-term observations and extensive data are needed further evaluate efficacy safety TAF, highlights need development robust novel direct-acting antivirals...
Abstract Background: Liver fibrosis is a major global health problem; nevertheless, its molecular mechanisms are not completely clear. This study aimed to build lncRNA-miRNA-mRNA network, identify potentially related lncRNAs, and explore the pathogenesis of liver fibrosis. Materials methods: We used Gene Expression Omnibus databases bioinformatics analysis differentially expressed genes (DEGs) between normal tissues. The ceRNA network was constructed according interactions DElncRNA, miRNA,...
Abstract Blood exchange therapy, specifically whole blood (WBE), is increasingly being utilized in clinical settings to effectively treat a range of diseases. Consequently, there an urgent requirement establish convenient and clinically applicable animal models that can facilitate the exploration therapy mechanisms. Our study conducted continuous (WBE) rats through femoral tail vein catheterization using dual-directional syringe pumps. To demonstrate applicability exchange, drug-induced...
Abstract Liver fibrosis is a major global health problem; nevertheless, its molecular mechanisms are not completely clear. The roles of long non-coding RNAs (lncRNAs) and their related competing endogenous (ceRNA) networks in liver unknown. This study aimed to build lncRNA-miRNA-mRNA network, identify potentially lncRNAs, explore the pathogenesis fibrosis. We used Gene Expression Omnibus databases bioinformatics analysis differentially expressed genes (DEGs) between normal tissues. ceRNA...