A5054367874- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Advanced Glycation End Products research
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Hepatitis Viruses Studies and Epidemiology
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diagnosis and treatment of tuberculosis
- Alcohol Consumption and Health Effects
- Pregnancy and Medication Impact
- COVID-19 diagnosis using AI
- Pancreatitis Pathology and Treatment
- Diabetes and associated disorders
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
European Foundation for the Study of Chronic Liver Failure
2025
The First Hospital of Changsha
2020
Changsha Central Hospital
2020
Third Affiliated Hospital of Guangzhou Medical University
2017-2019
Guangzhou Medical University
2017-2019
University of Pittsburgh
2013-2016
UPMC Hillman Cancer Center
2014-2016
Ferroptosis is a recently recognized form of regulated cell death caused by an iron‐dependent accumulation lipid reactive oxygen species. However, the molecular mechanisms regulating ferroptosis remain obscure. Here, we report that nuclear factor erythroid 2‐related 2 (NRF2) plays central role in protecting hepatocellular carcinoma (HCC) cells against ferroptosis. Upon exposure to ferroptosis‐inducing compounds (e.g., erastin, sorafenib, and buthionine sulfoximine), p62 expression prevented...
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide and currently has the fastest rising incidence all cancers. Sorafenib was originally identified as an inhibitor multiple oncogenic kinases remains only approved systemic therapy for advanced HCC. However, acquired resistance to sorafenib been found in HCC patients, which results poor prognosis. Here, we show that metallothionein (MT)-1G critical regulator promising therapeutic target human cells. The expression...
COVID-19 has attracted global attention due to its rapid spread around the world with substantial morbidity and associated mortality. Severe can be complicated by acute respiratory distress syndrome, sepsis septic shock leading death. These complications are thought result from an overactivation of immune system, a cytokine storm syndrome multiple organ failure. Here, we report that high mobility group box 1 (HMGB1), prototypical damage-associated molecular pattern (DAMP) central mediator...
Targeting immunometabolism is a strategy to prevent infection-mediated septic death.
Emerging studies have suggested that the Hippo pathway is involved in tumorigenesis of hepatocellular carcinoma (HCC). However, key regulator liver tumor metabolic reprogramming remains elusive. Here, we provide evidence high mobility group box 1 (HMGB1), a chromosomal protein, plays role regulation during tumorigenesis. Cre/loxP recombination-mediated HMGB1 depletion hepatocytes blocks diethylnitrosamine-induced cancer initiation mice, whereas short hairpin RNA-mediated gene silencing...
The role of M0 macrophages and their related genes in the prognosis hepatocellular carcinoma (HCC) remains poorly characterized.Multidimensional bioinformatic methods were used to construct a risk score model using macrophage-related (M0RGs).Infiltration was significantly higher HCC tissues than normal liver (P = 2.299e-07). Further analysis revealed 35 M0RGs that associated with prognosis; two (OLA1 ATIC) constructed validated as prognostic signature for overall survival patients HCC....
Significance: As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated in regulating stress responses to oxidative damage and cell death, which are closely related the pathology of inflammatory diseases, including cancer. Recent advances: HMGB1 non-histone nuclear protein that acts as DNA chaperone control chromosomal structure function. can also be released into extracellular space function damage-associated molecular pattern during apoptosis, necrosis, necroptosis,...
Hepatocellular carcinoma (HCC), one of the most common type cancers, is highly refractory to systemic therapies. Understanding genomic dysregulations, in particularly non-coding RNA (ncRNA) HCC may provide novel strategies treatment. In our previous study, we demonstrated key role miR-200a-mediated HMGB1/RAGE signaling carcinogenesis. present identified circular (circRNA)-miRNA pair that might modulate migration cell lines based on previously reported GEO database (GSE78520 and GSE43445)...
Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies and has an unfavorable prognosis. The hepatitis B virus X (HBx) protein been reported to be closely associated with hepatocarcinogenesis. Meanwhile, emerging evidence indicated that long noncoding RNAs (lncRNAs) are involved in pathogenesis progression cancers. Our previous investigation demonstrated HBx could promote HCC by regulating expression levels various lncRNAs. In this study, we identified lncRNA,...
Abstract Severe acute pancreatitis (AP) is responsible for significant human morbidity and mortality worldwide. Currently, no specific treatments AP exist, primarily due to the lack of a mechanistic understanding sterile inflammation resultant multisystem organ dysfunction, pathologic response linked early death. In this study, we demonstrate that class III major histocompatibility region receptor advanced glycation end products (RAGE) contributes by modulating inflammasome activation in...
Summary Background Data on tenofovir alafenamide fumarate (TAF) for preventing mother‐to‐child transmission of hepatitis B virus (HBV) are lacking. Aims To investigate the efficacy and safety TAF therapy transmission. Methods Mothers with chronic HBV infection, positive e‐antigen DNA >200 000 IU/mL received were enrolled retrospectively from multiple centres data collection mother‐infant dyads up to postpartum week 24‐28. Primary measurements rate infants' malformation rate. Secondary...
Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines induction pyroptosis. A dysfunctional inflammasome has been implicated in development human pathologies, including sepsis septic shock. Here, we show that advanced glycosylation end-product specific receptor (AGER/RAGE) is required for caspase-11 macrophages. nuclear damage-associated molecular pattern (nDAMP) complex, high-mobility group box 1, histone, DNA, promote...
To establish an early and quick model for diagnosing infections in patients with acute-on-chronic liver disease (AoCLD). This study analyzed 3,949 from two multicenter prospective cohorts of the Chinese Acute-on-Chronic Liver Failure (CATCH-LIFE) study. The dataset was randomly divided into training validation a 7:3 ratio. In cohort, logistic regression least absolute shrinkage selection operator analyses were used to identify predictive risk factors infection AoCLD, simple nomogram...
SLC1A4, a Na-dependent neutral amino acid transporter, was considered to participate in the various pathobiological process, including tumorigenesis. However, correlation between SLC1A4 and Hepatocellular Carcinoma (HCC) remains unclear. In our study, integrative bioinformatics functional profiling were performed reveal prognosis potential function of HCC. The results showed that mRNA protein levels elevated HCC, it powerful independent prognostic marker for overall survival (OS)....
Hepatic stellate cell (HSC) activation is a critical event in the development of hepatic fibrosis and hepatocellular carcinoma (HCC). By release soluble cytokines, chemokines, chemotaxis, HSCs affect HCC phenotypes through complex tumor microenvironment. In this study, weighted gene co-expression network analysis (WGCNA) was used to identify TGF-β signaling pathway as key Hep3B cells cultured HSC conditioned medium. MIR4435-2HG hub lncRNA associated with activation. HSC-condition medium (CM)...