A5036571865- Cancer-related molecular mechanisms research
- Vibrio bacteria research studies
- MicroRNA in disease regulation
- Bacterial Identification and Susceptibility Testing
- Circular RNAs in diseases
- Organ Transplantation Techniques and Outcomes
- Auditing, Earnings Management, Governance
- Pharmacological Effects and Toxicity Studies
- Immune Cell Function and Interaction
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- T-cell and B-cell Immunology
- Glaucoma and retinal disorders
- Liver Disease and Transplantation
- Corporate Governance and Financial Management
- Sepsis Diagnosis and Treatment
- Robotic Path Planning Algorithms
- Long-Term Effects of COVID-19
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Antibiotic Resistance in Bacteria
- Reinforcement Learning in Robotics
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Advanced Glycation End Products research
Xiangya Hospital Central South University
2013-2024
Central South University
2013-2024
Affiliated Eye Hospital of Wenzhou Medical College
2020
Wenzhou Medical University
2020
University of Portsmouth
2020
P73 antisense RNA 1 T (non-protein coding), also known as TP73-AS1, is a long non-coding (lncRNA) which involved in cell proliferation and the development of tumors. However, exact effects molecular mechanisms TP73-AS1 hepatocellular carcinoma (HCC) progression are still unknown. The present study aimed to investigate detailed functions mechanism regulation HCC proliferation.TP73-AS1 expression tissues lines was determined using real-time PCR assays; correlation with clinicopathological...
Hepatocellular carcinoma (HCC), one of the most common type cancers, is highly refractory to systemic therapies. Understanding genomic dysregulations, in particularly non-coding RNA (ncRNA) HCC may provide novel strategies treatment. In our previous study, we demonstrated key role miR-200a-mediated HMGB1/RAGE signaling carcinogenesis. present identified circular (circRNA)-miRNA pair that might modulate migration cell lines based on previously reported GEO database (GSE78520 and GSE43445)...
ABSTRACT Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has progressed to a pandemic associated with substantial morbidity and mortality. WHO the United States Center for Disease Control Prevention (CDC) have issued interim clinical guidance management of patients confirmed disease (COVID-19), but there is limited data on virologic characteristics prognosis COVID-19. Methods A total 50 COVID-19 were divided into good poor recovery groups. dynamic viral shedding...
Hepatic stellate cell (HSC) activation is a critical event in the development of hepatic fibrosis and hepatocellular carcinoma (HCC). By release soluble cytokines, chemokines, chemotaxis, HSCs affect HCC phenotypes through complex tumor microenvironment. In this study, weighted gene co-expression network analysis (WGCNA) was used to identify TGF-β signaling pathway as key Hep3B cells cultured HSC conditioned medium. MIR4435-2HG hub lncRNA associated with activation. HSC-condition medium (CM)...
This study aimed to investigate the prognostic value of a novel droplet digital polymerase chain reaction (DDPCR) assay in sepsis patients. In this prospective cohort study, univariable and multivariable Cox regressions were used assess risk factors for 28-day mortality. We also monitored pathogen load together with clinical indicators subgroup cohort. A total 107 patients positive baseline DDPCR results included. Detection poly-microorganisms [adjusted hazard ratio (HR) = 3.19; 95%...
To evaluate the use of plasma exchange (PE) combined with molecular adsorbent re-circulating system (MARS) for treatment liver failure complicated hepatic encephalopathy.A prospective randomized controlled study was conducted to compare therapeutic effect MARS (MARS group, n=60) that PE (PE+MARS in patients encephalopathy.The serum total bilirubin and blood ammonia levels were significantly decreased compared pretreatment after 3 days both (p=0.0001, p<0.001) PE+MARS (both p<0.0001) Glasgow...
Sepsis is still a major public health concern and medical emergency due to its high morbidity mortality. Accurate timely etiology diagnosis crucial for sepsis management. As an emerging rapid sensitive pathogen detection tool, digital droplet PCR (ddPCR) has shown promising potential in identification of pathogens antimicrobial resistance genes. However, the diagnostic value clinical impact ddPCR tests remains be studied patients with suspected sepsis. PROGRESS trial aimed evaluate...