A5079332093- Pancreatic function and diabetes
- Diabetes and associated disorders
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Adrenal and Paraganglionic Tumors
- Kruppel-like factors research
- Muscle Physiology and Disorders
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Apelin-related biomedical research
- Musculoskeletal synovial abnormalities and treatments
- Fibroblast Growth Factor Research
- Rheumatoid Arthritis Research and Therapies
- Hormonal Regulation and Hypertension
- Osteoarthritis Treatment and Mechanisms
Xiangya Hospital Central South University
2012-2025
Central South University
2012-2025
Loudi Central Hospital
2007
Second Xiangya Hospital of Central South University
2002
Abstract Context Primary aldosteronism (PA) is one of the leading causes secondary hypertension, and its diagnostic subtyping consistently presents a clinical challenge. Objective This study aimed to investigate potential 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) in PA classification applicability guiding development treatment plans by increasing sample size. Methods We prospectively enrolled 120 patients with either or nonfunctional adenoma (NFA) for...
Age-related osteoporosis is associated with the reduced capacity of bone marrow mesenchymal stem cells (BMSCs) to differentiate into osteoblasts instead adipocytes. However, molecular mechanisms that decide fate BMSCs remain unclear. In our study, microRNA-23a, and microRNA-23b (miR-23a/b) were found be markedly downregulated in aged mice humans. The overexpression miR-23a/b promoted osteogenic differentiation, whereas inhibition increased adipogenic differentiation. Transmembrane protein 64...
High bone mass (HBM) is usually caused by gene mutations, and its mechanism remains unclear. In the present study, we identified a novel mutation in long noncoding RNA Reg1cp that associated with HBM. Subsequent analysis 1,465 Chinese subjects revealed heterozygous individuals had higher density compared WT Reg1cp. Mutant increased formation of CD31hiEmcnhi endothelium marrow, which stimulated angiogenesis during osteogenesis. Mechanistically, mutant directly binds to Krüppel-like factor 3...
Currently, China has fully entered an aging society. The construction and efficient utilization of community older adult care facilities have become urgent issues that need to be addressed. To explore the differences in needs people for services, this study selected three basic needs: life care, medical security, cultural entertainment, as primary indicators needs. A demand indicator system was constructed, which included 11 secondary indicators. Based on system, a survey questionnaire...
Primary aldosteronism (PA) is the most common endocrine cause of hypertension. The plasma aldosterone-to-renin ratio (ARR) recommended screening tool for PA, but previous studies showed controversy regarding influence age on ARR. aim study was to evaluate impact ARR measured using direct renin concentration (DRC) and its diagnostic value in patients with PA. We retrospectively collected hypertension who attended Xiangya Hospital PA aldosterone (PAC)/DRC from January 1, 2017 November 2023....
Abstract Objectives CD31 hi EMCN vessels (CD31, also known as PECAM1 [platelet and endothelial cell adhesion molecule 1]; EMCN, endomucin), which are strongly positive for endomucin, couple angiogenesis osteogenesis. However, the role of in bone regeneration remains unknown. In present study, we investigated process regeneration. Materials Methods We used endothelial‐specific Krüppel like factor 3 ( Klf3 ) knockout mice ophiopogonin D treatment to interfere with vessel formation. constructed...
ABSTRACT Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has progressed to a pandemic associated with substantial morbidity and mortality. WHO the United States Center for Disease Control Prevention (CDC) have issued interim clinical guidance management of patients confirmed disease (COVID-19), but there is limited data on virologic characteristics prognosis COVID-19. Methods A total 50 COVID-19 were divided into good poor recovery groups. dynamic viral shedding...
Abstract Objectives Scavenger receptor class A, member 3 ( Scara3 ) was involved in adipogenesis. However, the effect of on switch between osteogenesis and adipogenesis bone marrow mesenchymal stem cells (BMSCs) remains elusive. Materials Methods The correlations SCARA3 with osteogenic‐related were analysed based GTEx database. effects osteogenic or adipogenic differentiation BMSCs evaluated by qPCR, Western blot (WB) cell staining. mechanisms regulating Foxo1 autophagy validated...
The present study evaluated the effects of KCNQ1 rs2237892 and rs2237895 polymorphisms on repaglinide efficacy in Chinese patients with type 2 diabetes mellitus (T2DM). In all, 367 T2DM 214 controls were genotyped. Forty randomly selected to undergo 8 weeks treatment. frequency allele was lower than control group (P < 0.05). C higher healthy subjects Diabetic risk had fasting insulin levels 0.01) homeostasis model assessment resistance (HOMA-IR; P values carriers T allele. plasma glucose...
Growth Differentiation Factor 8 (GDF8), also called myostatin, is a member of the transforming growth factor (TGF)-β super-family. As negative regulator skeletal muscle growth, GDF8 associated with bone metabolism. However, function in metabolism not fully understood. Our study aimed to investigate role metabolism, both vitro and vivo. results showed that had regulatory effect on primary mouse osteoblasts, promoted receptor activator nuclear κB ligand (RANKL)-induced osteoclastogenesis...
Growth differentiation factor 11 (GDF11) is an important circulating that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate relationship between serum level, mass, and turnover markers postmenopausal Chinese women. Serum biochemical markers, mineral density (BMD) were determined 169 women (47-78 years old). levels increased with There negative correlations BMD at various skeletal sites. After adjusting for age body...
Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is regulated by a variety intracellular regulatory factors including osterix, runt‑related transcription factor 2 (RUNX2), morphogenetic proteins and transforming growth factorβ. Recent studies have shown that microRNAs (miRs) serve crucial role in this process. In the present study, miR‑483‑3p levels were significantly increased during osteogenic mouse human BMSCs. Overexpression promoted differentiation, whereas...
Osteoporosis has gradually become a public health problem in the world. However, exact molecular mechanism of osteoporosis still remains unclear. Senescence and osteogenic differentiation inhibition bone marrow mesenchymal stem cells (BMSCs ) are supposed to play an important part osteoporosis.We used two gene expression profiles (GSE35956 GSE35958) associated with selected promising Ubiquitin-conjugating enzyme E2 E3 (UBE2E3). We then verified its function by vitro experiments.UBE2E3 was...
Background: Growth differentiation factor 15 (GDF15), is a newly identified member of the transforming growth factor-beta (TGF-β) family. It circulates as 24.5-kDa homodimer. However, function GDF15 in bone metabolism remains unclear. In this study, we investigated postmenopausal Chinese women.Methods: We measured serum levels, mineral density (BMD), and turnover markers 201 women ranging age from 47 to 80 years.Results: The concentration increased with age. levels displayed negative...
To determine serum levels of betatrophin in patients with polycystic ovary syndrome (PCOS) and the influential factors. A total 100 PCOS were enrolled randomly as a group, 40 age-matched healthy women recruited normal control (NC) group. Primary clinical or biochemical parameters subjects detected. The results analyzed by SPSS 19.0. Serum elevated group compared NC positively correlated age Whole Body Insulin Sensitivity Index (WBISI),and negatively body mass index, fasting insulin(FINS),...
Background Long noncoding RNA Gm31629 can regulate hypothalamic neural stem cells (htNSCs) senescence and the aging process. However, effect of on bone marrow mesenchymal (BMSCs) regeneration is unclear. In present study, we investigated effects BMSCs regeneration. Methods knockout ( -KO) wild-type (WT) mice were used to establish a model. The Brdu labelling, CCK8 assay, wound healing β-gal staining osteogenic differentiation assay assess functions BMSCs. Micro-computed tomography (CT),...
OBJECTIVE To investigate relationships between serum chemerin and bone mineral density (BMD) in patients with newly diagnosed Graves disease (GD). Methods: A total of 120 GD a course more than 3 months were enrolled from the Department Endocrinology June 2013 2015. Sixty age- sex-matched healthy people served as normal control. Serum levels chemerin, β-crosslaps (β-CTX), N-MID-osteocalcin (N-MID-OT) measured by ELISA. Fat mass BMD evaluated dual energy X-ray absorptiometry (DEXA). Results:...
Hypothalamic dysfunction leads to glucose metabolic imbalance; however, the mechanisms still need clarification. Our current study was explore role of hypothalamic Hnscr in metabolism.Using knockout or htNSC-specific overexpression mice, we evaluated effects on metabolism through GTTs, ITTs, serum indicator measurements, etc. Immunofluorescence staining and Western blotting were performed test inflammation levels insulin signalling hypothalamus. Conditioned medium intervene used investigate...