A5011690119- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Epilepsy research and treatment
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Adrenal and Paraganglionic Tumors
- Cancer, Lipids, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Neurological Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Monoclonal and Polyclonal Antibodies Research
- Nutritional Studies and Diet
- NF-κB Signaling Pathways
Xiangya Hospital Central South University
2015-2025
Central South University
2013-2025
Guiyang Medical University
2018-2025
West China Hospital of Sichuan University
2023-2025
Anqing City Hospital
2025
Anhui Medical University
2025
Sichuan University
2023-2025
The First People's Hospital of Guiyang
2024
Renmin Hospital of Wuhan University
2024
Wuhan University
2024
Abstract Astragalus polysaccharides (APS), which is widely used as a remedy to promote immunity of breast cancer patients, can enhance immune responses and exert anti-tumor effects. In this study, we investigated the effects mechanisms APS on macrophage RAW 264.7 EAC tumor-bearing mice. Griess reaction ELISA assays revealed that concentrations nitric oxide, TNF-α, IL-1β IL-6 were increased by APS. However, effect was diminished in presence TAK-242 (TLR4 inhibitor) or ST-2825(MyD88...
Abstract Context Primary aldosteronism (PA) is one of the leading causes secondary hypertension, and its diagnostic subtyping consistently presents a clinical challenge. Objective This study aimed to investigate potential 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) in PA classification applicability guiding development treatment plans by increasing sample size. Methods We prospectively enrolled 120 patients with either or nonfunctional adenoma (NFA) for...
The study is to evaluate biodistribution, dosimetry, safety, and clinical usefulness of F-AlF-NOTA-octreotide (F-OC) PET/CT in combination with F-FDG for detection neuroendocrine neoplasms (NENs).The safety F-OC were evaluated 3 healthy volunteers. Twenty-two NEN patients underwent at 60 minutes after intravenous injection 3.7 4.44 MBq (0.1-0.12 mCi) per kilogram body weight F-OC. This was followed by within a 2-week period.F-OC well tolerated all volunteers patients. calculated effective...
The blood flow, when restored clinically following a myocardial infarction (MI), disrupts the physiological and metabolic equilibrium of ischemic area, resulting in secondary damage termed ischemia-reperfusion injury (MIRI). Reactive oxygen species (ROS) generation inflammatory reactions stand as primary culprits behind MIRI. Current strategies focusing on ROS-scavenging anti-inflammatory actions have limited remission Prussian blue nanozyme (PBNz) exhibits multiple enzyme-like activities...
Severe reduced synaptic density was observed in spinocerebellar ataxia (SCA) postmortem neuropathology, but vivo assessment of loss remains challenging. OBJECTIVE SPINOCEREBELLAR ATAXIA TYPE 3: The objective this study to assess and its clinical correlates type 3 (SCA3) patients by vesicle glycoprotein 2A (SV2A)-positron emission tomography (PET) imaging.We recruited 74 SCA3 individuals including preataxic ataxic stages divided into two cohorts. All participants received SV2A-PET imaging...
Abstract The pancreatic stellate cells (PSCs) play an important role in the development of cancer (PC) through mechanisms that remain unclear. Exosomes secreted from PSCs act as mediators for communication PC. This study aimed to explore PSC‐derived exosomal small RNAs derived tRNAs (tDRs) PC cells. were extracted and used detect their effects on cell proliferation, migration invasion. Exosomal tDRs profiling was performed identify tDRs. ISH qRT‐PCR examine tRF‐19‐PNR8YPJZ levels clinical...
Lung cancer is the leading cause of cancer‑associated mortality worldwide. The aim present study was to identify differentially expressed genes (DEGs) and enriched pathways in lung by bioinformatics analysis, provide potential targets for diagnosis treatment. Valid microarray data 31 pairs tissues matched normal samples (GSE19804) were obtained from Gene Expression Omnibus database. Significance analysis gene expression profile used DEGs between tissues, a total 1,970 DEGs, which...
The loss of synaptic vesicle glycoprotein 2A (SV2A) is well established as the major correlate epileptogenesis in focal cortical dysplasia type II (FCD II), but this has not been directly tested vivo. In positron emission tomography (PET) study with new tracer 18F-SynVesT-1, we evaluated SV2A abnormalities patients FCD and compared pattern to 18F-fluorodeoxyglucose (18F-FDG).Sixteen proven 16 healthy controls were recruited. All underwent magnetic resonance imaging (MRI) static PET both...
Background Previous studies have shown the alteration of amino acid (AA) profile in patients with non-small cell lung cancer (NSCLC). However, there is little data regarding AA NSCLC Chinese population. The aim this study was to evaluate patients, explore its utility sample classification and further discuss related metabolic pathways. Methods concentrations 22 AAs serum samples from 200 202 healthy controls were determined by liquid chromatography-tandem mass spectrometer (LC-MS/MS). levels...
This study was performed to characterize the metabolic alteration of non-small-cell lung cancer (NSCLC) and discover blood-based biomarkers relevant detection. An untargeted metabolomics-based approach applied in a case-control with 193 NSCLC patients 243 healthy controls. Serum metabolomics were determined by using an ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method. We screened differential metabolites based on univariate multivariate analysis,...
Abstract Objective To evaluate the diagnostic efficacy of 18 F-AlF-NOTA-octreotide ( F-OC) PET/CT compared with that 68 Ga-DOTATATE PET/CT. Materials and methods Twenty patients (mean age: 52.65 years, range: 24–70 years) biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. We biodistribution profiles normal organs based on maximum standard uptake value (SUV max ) mean ), NEN lesions by measuring SUV F-OC images. The tumor-to-liver ratio (TLR)...
Introduction Due to the anti-inflammatory and antioxidant properties of cynaroside (Cyn), it may be useful in treatment cerebral ischemia/reperfusion injury (I/R). This study aims evaluate effect Cyn on injury. Methods Transient middle artery occlusion model (tMCAO) oxygen glucose deprivation/reperfusion (OGD/R) microglia models were used Cyn. The direct interaction between Alox15 was investigated through bioinformatics, molecular docking biolayer interferometry. Results tMCAO mice treated...
68 Ga-pentixafor PET/CT is a reliable, noninvasive functional imaging technique that demonstrates high classification accuracy for subtypes of primary hyperaldosteronism (PA) and provides significant guidance clinical treatment decisions. We report case the precise resection an aldosterone-producing adenoma (APA) while maximizing preservation adrenal glands under imaging.
The usefulness of serum carcinoembryonic antigen (CEA), carbohydrate (CA) 19-9, and CA72-4 for diagnosis, predicting progression, monitoring recurrence gastric cancer (GC) remains unclear. We conducted a retrospective investigation in this study. A total 564 GC cases were enrolled, 529 with benign disease recruited as controls. clinical data results biomarker detections collected. median concentrations (IQR) CEA, CA19-9, patients 2.38 ng/mL (1.47 - 4.47), 10.52 U/mL (6.17 20.20), 2.42 (1.26...
<title>Abstract</title> <bold>Background</bold> For patients diagnosed with primary aldosteronism accompanied by bilateral adrenal lesions, identifying optimal candidates for surgical intervention remains a significant clinical challenge. Although venous sampling (AVS) is currently the gold standard lateralizing aldosterone hypersecretion, its technical complexity, invasiveness, and interpretive difficulties restrict widespread adoption. In this study, we aimed to investigate application of...