A5101460470- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Mathematical and Theoretical Epidemiology and Ecology Models
- Polysaccharides and Plant Cell Walls
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Evolution and Genetic Dynamics
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 epidemiological studies
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Hypoxia, and Metabolism
- Nutrition, Genetics, and Disease
- Biocrusts and Microbial Ecology
- Mitochondrial Function and Pathology
- Respiratory viral infections research
- Cancer-related Molecular Pathways
China Pharmaceutical University
2025
Hangzhou Hospital of Traditional Chinese Medicine
2024-2025
Shandong Agricultural University
2025
Nanjing Medical University
2025
Harbin Medical University
2013-2024
Fourth Affiliated Hospital of Harbin Medical University
2017-2024
Jiangxi University of Traditional Chinese Medicine
2024
Anhui Agricultural University
2024
Xiangya Hospital Central South University
2022-2023
Central South University
2018-2023
Accumulating evidences have reported that the gut microbiota plays an important role in occurrence and progression of colorectal cancer. Commonly known as a kind constituent macromolecules, non-digestible polysaccharides always been fermented by intestinal microbiota. Nostoc commune Vaucher (N. commune) has appreciated healthy food supplementation worldwide it is rich nutrients. Particularly, account for 60% dry weight N. commune. In this study, we examined protective effects isolated from...
Abstract Context Primary aldosteronism (PA) is one of the leading causes secondary hypertension, and its diagnostic subtyping consistently presents a clinical challenge. Objective This study aimed to investigate potential 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) in PA classification applicability guiding development treatment plans by increasing sample size. Methods We prospectively enrolled 120 patients with either or nonfunctional adenoma (NFA) for...
Abstract Papillary thyroid cancer (PTC) is a kind of and frequently presents with epithelial–mesenchymal transition (EMT). MicroRNAs (miRNAs) were previously reported to be associated PTC. Thus, this study aims define the role microRNA‐520a‐3p (miR‐520a‐3p) in PTC through JAK/STAT signaling pathway by targeting JAK1 . The normal tissues 137 patients collected. First all, expression pattern miR‐520a‐3p, JAK1, JAK2, STAT3, E‐cadherin, vimentin was identified. relationship between miR‐520a‐3p...
Diabetic nephropathy (DN), the most severe microvascular consequence of diabetes mellitus (DM), is precursor to end-stage renal disease (ESRD). The development problems linked DN involves both oxidative damage and inflammation. Natural flavone acacetin (AC) has anti-inflammatory, antioxidant anti-cancer properties. However, effect AC on not clear.
Abstract Background The abnormal expression and overactivation of the epidermal growth factor receptor (EGFR), a typical cancer marker for non-small cell lung (NSCLC), are closely related to tumorigenesis progression NSCLC. However, endocytosis mechanism EGFR in is not yet known. Epsin3 (EPN3), member endocytic adaptor protein family, essential multiple receptors. In this study, we aimed investigate role EPN3 modulating function, its effects on NSCLC progression, potential involvement...
Physio-Cognitive Decline Syndrome (PCDs) is characterized by the coexistence of MIND (mobility impairment, no disability) and CIND (cognitive dementia), which predicts dementia risk. Deteriorating oral health can contribute to malnutrition, cognitive decline, physical frailty, all may exacerbate PCDs symptoms. This study investigates association between PCDs, exploring sex differences in this relationship. A cross-sectional analysis baseline data from Nanjing Brain Health Cohort included 252...
Paclitaxel resistance in ovarian cancer has become an urgent clinical problem. This study investigated the regulatory effects of RAB17 on non-coding RNA network paclitaxel-resistant cell A2780/PTX.Microarray analysis was used to identify differentially expressed genes A2780/PTX compared parent paclitaxel-sensitive A2780. Quantitative real-time PCR and Western blot were measure expression related mRNAs proteins. The CCK8 assay determine survival ratios drug indices cells. clone forming...
Ulcerative colitis (UC) is evolving into a global burden with substantially increasing incidence in developing countries. It characterized by inflammation confined to mucosa and recognized as an intestinal barrier disease. The microbiota plays crucial role UC pathogenesis. N. commune has long been appreciated healthy food supplement worldwide polysaccharides account for 60%. Here, we examined the amelioration of against acute mice induced DSS assessed mediating gut microbiota. An integrated...
In this study, we explored the circular RNA (circRNA) profile in pulmonary arterial hypertension (PAH) patients caused by chronic obstructive disease (COPD) and effects of hsa_circNFXL1_009 on abnormal proliferation, apoptosis, migration human smooth muscle cells (hPASMCs) driven hypoxia. Using microarrays, screened circRNA whole-blood samples from three pairs subjects found 158 dysregulated circRNAs with PAH-COPD. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)...
Nostoc commune Vauch. has been traditionally used as a healthy food and medicine for centuries especially in China. It demonstrated that the polysaccharides isolated from exhibit strong antimicrobial antioxidant activities. However, little is known about their anticancer activities underlying mechanisms of action. Herein, we report isolation polysaccharide (NVPS), its physicochemical properties were analyzed. In an attempt to demonstrate potential application NVPS tumor chemotherapy, vitro...
Actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1) plays an important role in the development and progression of several human cancers. However, its biological function gastric cancer (GC) is still unknown.We used qRT-PCR to detect relative expression AFAP1-AS1 GC tissues cell lines. The loss-of-function assays were conducted effect on development. Bioinformatics analysis, luciferase reporter gene RIP analysis identify validate target genes AFAP1-AS1. Finally, rescue tests...
microRNA-342-3p plays an important role in tumor occurrence and development. However, the expression pattern roles of nonsmall cell lung cancer remain poorly understood. In current study, we explored underlying mechanisms via gain- loss-of-function analyses. We used quantitative reverse-transcription-polymerase chain reaction western blotting assays to measure levels nonsmall-cell B-cell lymphoma-2. Furthermore, small interfering RNA mimics analyze functions cells. A luciferase reporter...
Colorectal carcinoma (CRC) is an aggressive malignancy with very limited therapeutic options. As a result, both morbidity and mortality of this are high. It well-established that Nostoc commune Vaucher type healthy food has been used as traditional medicine against human cancers. However, the underlying mechanism(s) by which inhibits CRC was never described. Here we reported polysaccharides from potent inhibitor growth activating macrophages. Specifically, purified two fractions these able...
Purpose: Lung cancer is one of the most prevailing human cancers worldwide. Emerging evidence implies that long non-coding RNA nicotinamide nucleotide transhydrogenase-antisense RNA1 (NNT-AS1) implicated in tumorigenesis lung cancer. Herein, we aimed to expose impact NNT-AS1 on drug resistance Methods: Levels NNT-AS1, microRNA (miR)-1236-3p and autophagy-related gene 7 (ATG7) were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR) assay....
The fruiting bodies of<italic>Hericium erinaceus</italic>(Bull.) Pers. are commonly used in China the treatment of digestive system diseases.
Nostoc commune Vauch., classified into cyanobacteria, has been always well appreciated as a healthy food and medicine worldwide owing to its rich nutrition potent bioactivities. Nevertheless, the inhibitory effect of polysaccharides from N. Vauch. (NVPS) against cancer cell progression metastasis is still being unraveled. The results in this study showed that NVPS remarkably suppressed migration through blocking epithelial-mesenchymal transition program NCI-H446 NCI-H1688 human small lung...
Abstract An SVIR epidemic model with continuous age structure in the susceptibility, vaccination effects and relapse is proposed. The asymptotic smoothness, existence of a global attractor, stability equilibria persistence are addressed. It shown that if basic reproductive number $\Re_0&lt;1$, then disease-free equilibrium globally asymptotically stable. If $\Re_0&gt;1$, disease uniformly persistent, Lyapunov functional used to show unique endemic Combined susceptibility age, on discussed.