A5101979239- Catalytic C–H Functionalization Methods
- MicroRNA in disease regulation
- Synthesis and Catalytic Reactions
- Plant biochemistry and biosynthesis
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Asymmetric Hydrogenation and Catalysis
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Food Quality and Safety Studies
- Digestive system and related health
- Lung Cancer Research Studies
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Birth, Development, and Health
- Plant Molecular Biology Research
- HER2/EGFR in Cancer Research
- Tea Polyphenols and Effects
- Growth Hormone and Insulin-like Growth Factors
- Colorectal Cancer Treatments and Studies
Huaqiao University
2021-2025
Nanjing University of Chinese Medicine
2019-2025
University of Science and Technology of China
2025
Shandong First Medical University
2015-2024
Shandong Tumor Hospital
2015-2024
Guizhou University
2023-2024
Harbin Medical University
2012-2023
Second Affiliated Hospital of Harbin Medical University
2017-2023
Shanghai Children's Hospital
2020-2023
Shanghai Jiao Tong University
2023
Cluster of differentiation 44 (CD44) as a transmembrane glycoprotein is found to be expressed in non‑small cell lung cancer (NSCLC), significantly associated with NSLC progression, metastasis and drug resistance. This study aimed explore whether CD44 inhibition improves the sensitivity epidermal growth factor receptor (EGFR) wild‑type NSCLC cells cisplatin how it affects EGFR cells. Small interfering RNA was used knockdown expression line H460. Results suggested that downregulation reduced...
Abstract Background The management of metastatic cancer remains a major challenge in therapy worldwide. targeted delivery chemotherapeutic drugs through rationally designed formulations is one potential therapeutic option. Notably, excipient-free nanodispersions that are entirely composed pharmaceutically active molecules have been evaluated as promising candidates for the next generation drug formulations. Formulated from self-assembly molecules, these enable safe and effective to local...
Sarcopenia significantly impacts prognosis in patients with acute ischemic stroke (AIS). This study investigates the relationship between serum creatinine/serum cystatin C (Cr/CysC) levels and short-term AIS patients, aiming to inform post-treatment strategies.
Herein, we firstly reported a series of biphenyl compounds bearing hydroxamic acid moiety as PD-L1/class I HDACs dual inhibitors. Among them, compound 14 displayed the strongest inhibitory activity in vitro against HDAC2 and HDAC3 with IC50 values 27.98 nM 14.47 nM, had an value 88.10 for PD-1/PD-L1 interaction. Importantly, could upregulate expression PD-L1 CXCL10 low-expression cancer cell line (MCF-7), highlighting potential to enhance efficacy by recruiting T-cell infiltration into TME...
In this study, we explored the circular RNA (circRNA) profile in pulmonary arterial hypertension (PAH) patients caused by chronic obstructive disease (COPD) and effects of hsa_circNFXL1_009 on abnormal proliferation, apoptosis, migration human smooth muscle cells (hPASMCs) driven hypoxia. Using microarrays, screened circRNA whole-blood samples from three pairs subjects found 158 dysregulated circRNAs with PAH-COPD. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)...
Methyl groups widely exist in bioactive molecules, and site-specific methylation has become a valuable strategy for their structural functionalization. Aiming to introduce this smallest alkyl handle, highly regioselective
Rho family GTPases are critical regulators of many important cellular processes and the dysregulation their activities is implicated in a variety human diseases including oncogenesis propagation malignancy. The traditional methods, such as "pull-down" or two-hybrid procedures, poorly suited to dynamically evaluate activity GTPases, especially living mammalian cells. To provide novel alternative approach analyzing GTPase-associated signaling pathways vivo, we developed series bioluminescent...
Both circulating tumor cells (CTCs) and epithelial-mesenchymal transition (EMT) play an important role in invasion, migration chemoresistant development. This study aimed to detect whether EMT occurred human gastric CTCs explore the mechanism of CTCs. We analysed epithelial markers (pan-CK, E-cadherin), mesenchymal (N-cadherin, vimentin) related miR‑200s, Akt The impact miR‑200s on EMT, invasion was tested. found that pan-CK, E-cadherin were decreased, N-cadherin, vimentin overexpressed...
The dysfunction of cell apoptosis is an important event in the progression cancer, and growth cancer cells negatively regulated by apoptosis. In different types cancers, inhibition cellular often observed cancerous tissue, increased resistance to a hallmark cancer. Although previous studies have shown that 12-lipoxygenase (12-LOX)/12-hydroxyeicosatetraenoic acid (12-HETE) activated upregulated consequences 12-LOX/12-HETE upregulation its precise roles survival ovarian carcinoma are still...
An efficient divergent approach of Pd-catalyzed C-H oxygenation polyaromatic rings is described. Reversible directing groups enable regiospecific peri- and ortho-oxygenation to readily access a wide array phenols without pre- postmanipulation groups. The systematic mechanistic investigation, including deuterium-labeling experiments, palladacycle trapping, DFT calculations, reveals that the tunable ligand-assisted bond cleavage played crucial role during reaction process.
Abstract Divergent synthesis of heterocycles with controllable ring sizes from the same starting materials is a long‐standing challenge. We report herein first example divergent [4+5] and [2+3] cycloadditions α,β‐unsaturated imines vinylethylene carbonates, which enables selectively nine‐membered different five‐membered by controlling reaction temperature steric hindrance substituent. This protocol features broad substrate scope, wide functional group tolerance as well operational...
Abstract We demonstrated herein the four modes in free‐radical C−C formation reaction of isocyanide with alcohol. The experimental results and DFT calculation revealed when why one model opens. It would be instructive valuable for radical alkylation alcohol organic synthesis. magnified image
In this study, we aimed to analyze the anti-cancer effects of β-elemene combined with paclitaxel for ovarian cancer. RT-qPCR, MTT assay, western blot, flow cytometry, and immunohistochemistry were used in vitro vivo treatment paclitaxel. The results showed that β-elemene+paclitaxel markedly inhibited cancer cell growth, migration, invasion compared either or alone. Results demonstrated induced apoptosis SKOV3 cells, down-regulated anti-apoptotic Bcl-2 Bcl-xl gene expression up-regulated...