A5057631682- Autoimmune and Inflammatory Disorders Research
- Cardiac Valve Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Rheumatoid Arthritis Research and Therapies
- Nanoparticle-Based Drug Delivery
- Asthma and respiratory diseases
- Infective Endocarditis Diagnosis and Management
- Extracellular vesicles in disease
- Fatty Acid Research and Health
- Blood properties and coagulation
- Electrospun Nanofibers in Biomedical Applications
- Platelet Disorders and Treatments
- Spondyloarthritis Studies and Treatments
- Dermatology and Skin Diseases
- Photodynamic Therapy Research Studies
- Food Supply Chain Traceability
- Hippo pathway signaling and YAP/TAZ
- Fluid Dynamics and Heat Transfer
- Chemical Looping and Thermochemical Processes
- Laser-Matter Interactions and Applications
- Dental materials and restorations
- Dermatologic Treatments and Research
- Fluoride Effects and Removal
- Acne and Rosacea Treatments and Effects
- Pharmacogenetics and Drug Metabolism
Copenhagen Prospective Studies on Asthma in Childhood
2023-2025
University of Copenhagen
2023-2025
Gentofte Hospital
2023-2024
Sichuan University
2010-2024
State Key Laboratory of Hydraulics and Mountain River Engineering
2024
Yibin University
2024
Huazhong University of Science and Technology
2023
AbbVie (United States)
2021-2022
Jilin University
2022
Chengdu University
2019-2020
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is frequently over-expressed and serves as a prognostic marker in human cancers. However, little known about the role of MALAT1 gastric cancer. Here, we reported that tissue plasma levels were significantly higher cancer patients with distant metastasis (P<0.01) than without healthy controls. In addition, high independently correlated to poor prognosis for (hazard ratio, 0.242; 95% CI, 0.154-0.836; P=0.036; Cox regression...
Background In SELECT-PsA 1, a randomised double-blind phase 3 study, upadacitinib 15 mg and 30 were superior to placebo non-inferior adalimumab in ≥20% improvement American College of Rheumatology (ACR) criteria at 12 weeks patients with psoriatic arthritis (PsA). Here, we report 56-week efficacy safety from 1. Methods Patients received or once daily, 40 every other week for 56 through 24 switched thereafter until 56. Efficacy endpoints included the proportion achieving ≥20%/50%/70% ACR...
Atherosclerosis, the principle cause of cardiovascular disease (CVD) worldwide, is mainly characterized by pathological accumulation diseased vascular cells and apoptotic cellular debris. Atherogenesis associated with upregulation CD47, a key antiphagocytic molecule that known to render malignant resistant programmed cell removal, or “efferocytosis.” Here, we have developed platelet membrane-coated mesoporous silicon nanoparticles (PMSN) as drug delivery system target atherosclerotic plaques...
Osteosarcoma is the most common primary malignancy of bone. The long-term survival osteosarcoma patients hinges on our ability to prevent and/or treat recurrent and metastatic lesions. Here, we investigated activation peroxisome proliferator-activated receptor gamma (PPARgamma) retinoid receptors as a means differentiation therapy for human osteosarcoma.We examined endogenous expression PPARgamma in panel cells. Ligands or adenovirus-mediated overexpression these were tested inhibit...
ABSTRACT Objective: To compare the esthetic improvements of white-spot lesions (WSLs) treated by fluoride, casein phosphopeptide amorphous calcium phosphate (CPP-ACP), or resin infiltration. Materials and Methods: WSLs were created on human enamel randomly assigned to four groups: NaF (500 ppm), CPP-ACP, infiltration (Icon), distilled deionized water (DDW; control group). The color change (ΔE) each specimen was measured with a Crystaleye spectrophotometer, fluorescence loss (ΔQ) quantitative...
The strategy of novel multi-stimuli response and synergistic chemo–photodynamic therapy nanoplatform will be helpful for exploiting intelligent cancer therapy.
Rationale: Pediatric asthma is heterogeneous, with varied clinical presentations and treatment responses. Metabolomic profiling may uncover shared unique biological mechanisms across traits that characterize pediatric asthma. Objectives: To the presentation of by examining metabolome's relationship 22 traits, categorized into 5 phenotypic domains: airway hyperresponsiveness (AHR), atopy, lung function (LF), blood eosinophil (B-EOS), neutrophil (B-NEU). Methods: was conducted on plasma...
The diagnosis of melasma is often based on the naked-eye judgment physicians. However, this a challenge for inexperienced physicians and non-professionals, incorrect treatment might have serious consequences. Therefore, it important to develop an accurate method diagnosis. objective study validate intelligent diagnostic system deep learning images.A total 8010 images in VISIA system, comprising 4005 patients with without melasma, were collected training testing. Inspired by four...
Vertical transmission of metabolic constituents from mother to child contributes the manifestation disease phenotypes in early life. This study probes vertical metabolites mothers offspring by utilizing machine learning techniques differentiate between true mother-child dyads and randomly paired non-dyads. Employing random forests (RF), light gradient boosting (LGBM), logistic regression (Elasticnet) models, we analyzed metabolite concentration discrepancies pairs, with maternal plasma...
Polymeric micelles with stimuli-triggered drug release and AIE active bioimaging have emerged as potential candidates for theranostics. Herein, a curcumin (Cur) loaded oxidation-responsive mPEG-b-PLG (Se)-TP polymeric micelle system great aggregation-induced emission (AIE) two-photon imaging property has been developed simultaneous antitumor treatment bioimaging. Cur-loaded core–shell structure homogeneous size of 136 nm show physiological stability while rapidly disassemble under oxidation...
Many patients with psoriatic arthritis do not reach minimal disease activity (MDA) on methotrexate alone. This phase 4 open-label study aimed to compare attainment of MDA following introduction adalimumab escalation in who after an initial course (≤15 mg every week).
Hydrogel/porcine pericardium hybrid provides a more biocompatible biomaterial for the pre-mounted TAVI valve.
Abstract Nanocarriers with minimal drug leakage in blood and sufficient release at tumor sites are essential for targeted delivery bioimaging. Herein, a reactive oxygen species (ROS) glutathione (GSH) dual‐responsive aggregation‐induced quenching (ACQ) prodrug micelle system is developed based on PMPC‐P (Se‐ co ‐RB)‐P (SS‐GEM) copolymer to avoid specifically locate the via ROS‐triggered fluorescence turn manner. Selenium (Se) group designed respond ROS environment of so as Rhodamine B (RB)...
Nanocarriers have been an important strategy for enhancing the combination therapy of chemotherapy and photodynamic (PDT) (Chem-PDT).
Efficient component separation technology is one of the key ways to improve efficiency lignocellulose bioconversion. In this study, formic acid method was used separate components from Miscanthus lutarioriparius, hemicellulose degraded into xylose simultaneously, and composition structure separated were analyzed. Then, further purified with activated carbon for decolorization resins removal other monosaccharide impurities. The results showed that could effectively cellulose, hemicellulose,...
Abstract The lifetime of bioprosthetic heart valves (BHVs) is limited by the mechanical damage and calcification. major components BHVs are collagen elastin. Collagen could be well protected glutaraldehyde (GLUT) crosslinking, while elastin not stabilized has a high risk degradation, which lead to calcification BHVs. We aimed develop methods for stabilizing decreasing investigated combined tannic acid (TA) or epigallocatechin gallate (EGCG) with ferric chloride stabilize prevent found that...
Amino-terminal enhancer of split (AES) is a member the Groucho/TLE family. Although it has no DNA-binding site, AES can regulate transcriptional activity by interacting with factors. Emerging evidence indicates that may play an important role in tumor metastasis, but molecular mechanism still poorly understood. In this study, we found knockdown RNA interference (RNAi) downregulated RND3 expression at mRNA and protein levels MDA-MB-231 HepG2, two cancer cell lines. Furthermore, luciferase...
Eicosanoids are lipid mediators including thromboxanes (TXs), prostaglandins (PGs), and leukotrienes with a pathophysiological role in established atopic disease. However, their the inception of disease is unclear. This study aimed to investigate association between urinary eicosanoids early life development