A5101964510- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- HER2/EGFR in Cancer Research
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Galectins and Cancer Biology
- RNA modifications and cancer
- Biosimilars and Bioanalytical Methods
- Histone Deacetylase Inhibitors Research
- Clinical Laboratory Practices and Quality Control
- RNA Interference and Gene Delivery
- Renal Transplantation Outcomes and Treatments
- T-cell and Retrovirus Studies
- Reproductive System and Pregnancy
University Health Network
2012-2025
Toronto General Hospital
2012-2025
Xijing Hospital
2013-2024
Air Force Medical University
2013-2024
Guangdong University of Technology
2022
Peking University First Hospital
2022
Peking University
2022
Chinese People's Liberation Army
2015
University of Toronto
2015
Qilu Hospital of Shandong University
2012
Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the mechanisms drive this process remain elusive. Here, we show critical importance tumor-derived TLR2 ligands generation immunosuppressive IL-10-producing human and mouse DCs. ligation induced two parallel synergistic processes converged activate STAT3: stimulation autocrine IL-6 IL-10 upregulation their respective surface receptors, which...
The 26S proteasome inhibitor, bortezomib, has shown remarkable therapeutic efficacy in multiple myeloma (MM), however, the mechanism by which this compound acts remains unknown. Here, we have demonstrated that bortezomib targets prototypical expression of unfolded protein response (UPR) genes BiP, CHOP and XBP-1 at mRNA levels, resulting induction proapoptotic UPR outputs suppression cytoprotective components, leading to caspase-dependent apoptosis human MM H929 8226/S cell lines. Moreover,...
Dihydroartemisinin (DHA), a semi-synthetic derivative and active metabolite of artemisinin, has been shown to have profound anticancer potential in addition its strong anti-malarial activity. The purpose the present study was thoroughly investigate anti-neoplastic effects induced by DHA provide molecular basis for use treatment breast cancer. Our results demonstrated that could significantly inhibit cell proliferation cancer dose- time-dependent manner associated with apoptosis G0/G1 cycle...
The success of adoptive CTL therapy for cancer depends on interactions between tumor-infiltrating CTLs and cells as well other molecules in the tumor microenvironment. Tumor dendritic (DCs) comprise several subsets: CD103+CD11b- DC1 CD11b+CD64- DC2, which originate from circulating precursors conventional DCs, CD11b+CD64+ DC3, arise monocytes. It remains controversial these subset(s) promotes intratumor proliferation, expansion, function. To address this issue, we used Zbtb46-DTR-transgenic...
Abstract Multiple myeloma is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces apoptosis in multiple cells; however, the mechanism by which this compound acts remains unknown. Here, we, using immunoblotting analysis, observed that expression of BiP, CHOP, and XBP-1 up-regulated bortezomib-induced human lines NCI-H929 RPMI-8226/S, strongly suggesting endoplasmic reticulum (ER) stress response or unfolded protein (UPR), a signaling pathway...
Psoriasis is reported to be a common chronic immune-mediated skin disease characterized by abnormal keratinocytes and cell proliferation. Perilla leaves are rich in essential oils, fatty acids, flavonoids, which recognized for their antioxidant anti-inflammatory effects. In this study, the alleviating effect of oil (PO) extracted from frutescens stems on imiquimod (IMQ) -induced psoriasis-like lesions BALB/c mice were investigated. Results showed that PO ameliorated vivo, reduced expression...
Aplastic anemia (AA) is an autoimmune disease in which T cell activation suspected to play important role. immunoglobulin and ITIM (immunoreceptor tyrosine-based inhibition motif) domain (TIGIT) inhibitory receptor, exhibits functions on the immune response. However, its role AA has not been clearly determined. In current study, we showed that frequency of TIGIT-positive CD4(+) cells was reduced vast majority patients (85%, 17/20). TIGIT-silenced human cells, stimulation agonistic anti-TIGIT...
To investigate the possible role of CD147 and vascular endothelial growth factor in progression prognosis acute myeloid leukemia. Immunohistochemical staining was performed to detect expression paraffin-embedded sections from 62 bone marrow biopsies obtained an equal number patients with newly diagnosed leukemia were significantly higher than those normal controls (both P < 0.001). Expression them increased a high degree microvessel density compared low (CD147: = 0.009; factor: 0.01)...
Multiple myeloma (MM) is a hematopoietic malignancy characterized by the clonal proliferation of antibody-secreting plasma cells. Bortezomib (BZM), first FDA-approved proteasome inhibitor, has significant antimyeloma activity and prolongs median survival MM patients. However, remains incurable predominantly due to acquired drug resistance disease relapse. β-Catenin, key effector protein in canonical Wnt signaling pathway, been implicated regulating cell sensitivity BZM. Decitabine (DAC) an...
<b><i>Background:</i></b> Acute myeloid leukemia (AML) recurrence is largely a result of multidrug resistance (MDR). We aimed to examine the role 14-3-3&#x03B6; in AML chemosensitivity using HL-60 and vincristine-resistant HL-60/VCR cells. <b><i>Methods:</i></b> The effects siRNA on growth cell cycle progression cells were determined. effect topotecan (TPT)-induced apoptosis was evaluated by several assays....
<b><i>Background:</i></b> Extranodal natural killer (NK)/T cell lymphoma (ENKTL) is an aggressive non-Hodgkin's with high mortality and poor prognosis despite radiotherapy chemotherapy. The current analysis aimed to assess the pathological features, clinical prognostic indicators of ENKTL. <b><i>Material Methods:</i></b> 120 ENKTL patients were analyzed for pathologic diagnosis disease manifestations from April 2007 October 2012. Complete...
This study aimed to investigate clinical characteristics and survival outcomes of primary cutaneous T-cell lymphoma (CTCL) in HIV-infected non-HIV-infected patients. All data were from the Surveillance, Epidemiology, End Results program, 1973-2013, U.S. National Cancer Institute. Data 318 patients 1272 with CTCL analyzed. Endpoints overall cancer-specific mortality. Independent variables included demographics, pre-existing malignancy, treatments, environmental factors. Among 8823 CTCL, (3.60...