A5012193124- Reproductive System and Pregnancy
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
- Cancer-related Molecular Pathways
- Bone and Dental Protein Studies
- Cancer Mechanisms and Therapy
Qilu Hospital of Shandong University
2013-2024
Hunan Cancer Hospital
2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2009-2023
Shandong University
2009-2020
Liaocheng People's Hospital
2016-2019
Shandong First Medical University
2008-2018
Stomatology Hospital
2017
Georgetown University
2016
Shandong Provincial QianFoShan Hospital
2016
MedStar Georgetown University Hospital
2016
Abstract Background Notch1 is a potent regulator known to play an oncogenic role in many malignancies including T-cell acute lymphoblastic leukemia (T-ALL). Tumor hypoxia and increased hypoxia-inducible factor-1α (HIF-1α) activity can act as major stimuli for tumor aggressiveness progression. Although hypoxia-mediated activation of the pathway plays important cell survival invasiveness, interaction between HIF-1α has not yet been identified T-ALL. This study was designed investigate whether...
Hypoxia is a common characteristic of many pathological and physiological conditions that can markedly change cellular metabolism cause the accumulation extracellular adenosine. Recent studies have shown adenosine modulate function certain immune cell types through binding with different receptors. Our previous hypoxia has an effect on biological activity dendritic cells (DCs) by inducing their differentiation towards Th2 polarising phenotype. However, mechanisms underlying this suppression...
CTLA-4 is a negative regulator of the proliferation and effector function T-cells. Therefore, it might be important to determine its expression on tumor cells T-lymphocytes from cancer patients, investigate role in initiating maintaining neoplastic pathogenesis. was detected breast tissue by immunohistochemical staining RT-PCR 60 patients with 30 normal controls. The levels T lymphocytes 33 27 control group were determined flow cytometry. Isolated peripheral blood mononuclear (PBMCs)...
Summary It is well recognized that tissue microenvironments are involved in regulating the development and function of dendritic cells (DC). Oxygen supply, which varies different tissues, has been accepted as an important microenvironmental factor biological functions several immune being tumour progression metastasis. However, little known about effect hypoxia on DC these hypoxia‐conditioned In this study, we analysed transcriptional profiles human monocyte‐derived immature (imDC) mature...
The importance of ectoenzymes CD39 and CD73 in mediating adenosinergic immunosuppression has been recognized, but their roles human malignant glioma–associated remain largely unknown. In this study, the ectoenzyme characteristics glioma cells infiltrating CD4+ T lymphocytes isolated from newly diagnosed patients were investigated. activities both cell populations determined by nucleotide hydrolysis assay. immunosuppressive property CD39-CD73 synergic effect was evaluated via responder T-cell...
Abstract Background Phosphorus (P) is an essential macronutrient for all living organisms. Maize ( Zea mays ) important human food, animal feed and energy crop throughout the world, enormous quantities of phosphate fertilizer are required maize cultivation. Thus, it to improve efficiency use maize. Results In this study, we analyzed root response starvation performed a transcriptomic analysis 1.0-1.5 cm lateral primordium zone. growth plants, root-to-shoot ratio (R/L) was reduced in both...
NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in maintaining immune tolerance during pregnancy. The mechanisms that facilitate to fetal tissue are largely unknown. T cell Ig mucin domain-containing protein 3 (Tim-3) is a newly defined molecule with immunological function many physiological pathological processes. Recent study showed Tim-3 was involved regulation of MFI. However, whether regulates cytotoxicity toward trophoblasts unclear. Here, we mainly...
The brain microenvironment has emerged as an important component in malignant progression of human glioma. However, astrocytes, the most abundant glial cells glioma microenvironment, have yet a poorly defined role development this disease, particularly with regard to invasion. Here, we co-cultured astrocytes cell lines, U251 and A172, vitro transwell system order ascertain their influence on migration invasion gliomas. mRNA protein expression assays were subsequently used identify candidate...
Abstract In tumor microenvironment, macrophages as a polarized M2 population promote progression via releasing multiple cytokines and chemokines. A brown seaweed fucose-rich polysaccharide, fucoidan has antitumor activity immune modulation through affecting cells lymphocytes. Here, we focused on the effect of especially subtype. Our results demonstrated that down-regulated partial chemokines, M2-type chemokine CCL22. Furthermore, inhibited migration CD4 + T lymphocytes, Treg cells,...
Triggering receptor expressed on myeloid cells 1 (TREM1), which belongs to the Ig-like superfamily cells, is reportedly involved in various diseases but has rarely been studied glioma. In this study, prognostic value and functional roles of TREM2 glioma were analyzed. TERM1 was observed be significantly upregulated GBM compared other grade gliomas associated with poor prognosis. Increased TREM1 accompanied distinct mutation amplification driver oncogenes. Moreover, gene ontology KEGG...
The purpose of this study was to test the hypothesis that overexpression angiotensin-converting enzyme 2 (ACE2) may favorably affect left ventricular (LV) remodeling and function after myocardial infarction (MI). anterior descending coronary artery ligated produce MI in 100 Wistar-Kyoto rats were randomly divided into Ad-ACE2, Ad-ACE2+A779, Ad-EGFP, model, sham groups. Two weeks later, Ad-ACE2 Ad-EGFP groups received direct intramyocardial injection respectively. Rats Ad-ACE2+A779 group both...
Objective The present study aimed to explore the clinical significance of neutrophils infiltration and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) expression in tongue squamous carcinoma (TSCC), probe possible relationship between them. Materials Methods Tissue microarray immunohistochemistry were used detect density CEACAM1 74 cases primary TSCC specimens 17 corresponding peritumoral tissues. with clinicopathologic parameters cancer-related survival patients...
Tumor-infiltrated macrophages were potential targets of the immune therapy for patients with colon cancer. Colony stimulating factor 1 (CSF1) is a primary chemoattractant and functional regulator macrophages, therefore would be feasible intervention macrophage-targeting therapeutics. However, expression CSF1 in cancer microenvironment its roles development largely unknown. In present study, we found that was over-expressed exclusively cells correlated infiltration. The high infiltration...
Kinesin family member 2a (KIF2A), a type of motor protein found in eukaryotic cells, is associated with development and progression various human cancers. The role KIF2A during breast cancer tumorigenesis was studied. Immunohistochemical staining, real time RT-PCR western blot were used to examine the expression tissues adjacent normal from patients. Patients' survival relation estimated using Kaplan–Meier multivariate analysis. Breast cell line, MDA-MB-231 study proliferation, migration...
Abstract Rho GTPase-activating proteins (RhoGAPs) are implicated in the development and progression of ovarian cancer. ARHGAP10 is a member RhoGAP inactivates Cdc42 by converting GTP-bound form to GDP-bound form. Here, we aimed evaluate expression profile functions The decreased was found 77.3% (58/75) cancer tissues, compared with their non-tumorous counterparts. Furthermore, overall survival patients higher longer than those lower expression. Ectopic two cell lines (A2780 HO-8910)...
Galectin-9 is a widely expressed protein that involved in immune regulation and tumorpathogenesis serves as marker of poor prognosis various types cancers. However, the clinical impact precise mechanism by which this contributes to colon tumor progression are unclear. In present study, we detected expression galectin-9 CD56 cells using immunohistochemistry. Spearman's rank correlation was used clarify association between natural killer (NK) cell infiltration. The influence on NK-92 migration...
Abstract Tumor‐associated macrophages (TAMs) exert tumor‐promoting effects. There have been reports that estrogen receptors (ERs) are expressed on the infiltrating of endometriosis, ovarian cancer and lung cancer. However, role ERs in is not well characterized. In this study, we identified ER alpha (ERα) expression human endometrial was positively correlated with progression. Conditioned medium from selective ERα agonist‐treated M2 induced epithelial to mesenchymal transition (EMT) cells....