A5101848841- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Oral and Maxillofacial Pathology
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Bone Tumor Diagnosis and Treatments
- Cancer, Hypoxia, and Metabolism
- Tumors and Oncological Cases
- Cardiac Ischemia and Reperfusion
- Immune cells in cancer
- Calpain Protease Function and Regulation
- Cytokine Signaling Pathways and Interactions
- Oral Health Pathology and Treatment
- Recycling and Waste Management Techniques
- Bone health and treatments
- Teratomas and Epidermoid Cysts
- Tissue Engineering and Regenerative Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Prostate Cancer Treatment and Research
- FOXO transcription factor regulation
- Endodontics and Root Canal Treatments
Qingdao University
2014-2024
Affiliated Hospital of Qingdao University
2014-2024
Capital Medical University
2019-2021
Shanghai Ninth People's Hospital
2005
Oral squamous cell carcinoma (OSCC) is the most common malignancy of oral cavity. In tumor microenvironment, tumor-associated neutrophils (TANs) can promote growth, invasion, and metastasis. The aim our study was to explore relationship between infiltration Chemerin expression in cells, as well their with clinicopathological parameters clinical prognosis 74 cases OSCC. We also explored role interaction functions OSCC cells (Cal27, SCC9, SCC15) vitro . Our results showed that OSCC,...
Objective The present study aimed to explore the clinical significance of neutrophils infiltration and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) expression in tongue squamous carcinoma (TSCC), probe possible relationship between them. Materials Methods Tissue microarray immunohistochemistry were used detect density CEACAM1 74 cases primary TSCC specimens 17 corresponding peritumoral tissues. with clinicopathologic parameters cancer-related survival patients...
The present study aimed to investigate the significance of hedgehog signaling pathway in association with clinicopathology parameters and its effect on angiogenesis oral squamous cell carcinoma (OSCC). expression Sonic Hh (Shh) Gli1 were done primary tumors metastatic lymph nodes OSCC samples from 80 patients by immunohistochemical analysis. western blot was used examine Shh lines OSCC-derived microvesicles (MVs). role carried MVs induce endothelial further investigated matrigel assay. Our...
Abstract Background The relationship between chronic periodontitis and pulpal/cemental changes is seldom reported. This study aimed to report on the microstructural of cementum histopathological features dental pulp in teeth with severe periodontitis. Methods Eighty molar 50 extracted third molars (as normal controls) were collected. microstructure was evaluated by scanning electron microscopy, stained hematoxylin eosin. Interleukin (IL)‐17 IL‐1β levels examined immunohistochemistry/western...
Dietary nitrate, found abundant in green vegetables, can be absorbed into the blood and converted to nitric oxide (NO) body. nitrate has been proved have many positive physiological functions Here, we evaluated therapeutic effects of dietary on skin flap recovery following ischemia reperfusion (IR). Wistar rats were pretreated with from one week prior end reperfusion. It was that oral administration increased serum nitrite levels, protected cells apoptosis, attenuated tissue edema. In...
The association between the hypoxia-inducible gene termed regulated in development and DNA damage responses 1 (REDD1) microvessel density (MVD) human oral cancer has rarely been reported. present study aimed to explore REDD1 expression squamous cell carcinoma (OSCC), its clinical prognostic significance correlation with angiogenesis. 23 pairs of fresh-frozen OSCC matched peritumoral mucosal tissues was quantified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
Carcinoembryonic antigen cell adhesion molecule 1 ( CEACAM 1), a transmembrane glycoprotein, has multiple functions. In tongue squamous carcinoma TSCC ), overexpression is correlated with neutrophil infiltration, and both are associated poor clinical outcomes. However, the mechanism underlying 1's effect on function in remains unclear. We cocultured cells overexpressing 1‐4L, 1‐4S differentiated HL ‐60 cells. This significantly upregulated expression of MMP ‐9, interleukin 8, VEGF ‐A...
ObjectivesChemerin, as a novel multifunctional adipokine, is proposed to be involved in high cancer risk and mortality. The present study was aimed evaluate the prognostic value of serum Chemerin neutrophils patients with oral squamous cell carcinoma (OSCC).Materials methods120 OSCC were included this prospective cohort study. levels measured by enzyme-linked immunosorbent assay (ELISA). We also explored possible effects on neutrophils' chemokines using real-time PCR, western...
The aim of the present study was to investigate generation cell sheet-engineered bones used for reconstruction mandibular defects. Bone marrow stem cells (BMSCs) were cultured and induced generate osteoblasts. Poly(lactic-co-glycolic acid) (PLGA) scaffolds wrapped with or without sheets then implanted into dogs defects in right side (experimental group) left (control group), respectively. Subsequently, X-ray analyses, hematoxylin eosin staining performed at various time points (at 4, 8, 12...
The present study reports two cases of mandibular metastasis from hepatocellular carcinoma (HCC), including the clinical presentation, and computed tomography (CT), histopathology immunohistochemistry results. Space‑occupying lesions occurred unilaterally as an initial manifestation. HCC was confirmed by post‑surgical examination, primary tumor found using CT scans. Hepatitis B virus infection history positive results hepatitis surface antigen, e‑antibody, core antibody pre‑S1 antigen...
Constituents of tobacco that can cause DNA adduct formation and oxidative stress are implicated in the development head neck squamous cell carcinoma (HNSCC). However, there few studies on mechanism(s) underlie tobacco-associated HNSCC. Here, we used a model which tumors were induced rats using 4-nitroquinoline 1-oxide (4NQO), mimicked tobacco-related HNSCC, analyzed expression profiles microRNAs mRNAs. Our results indicated 57 miRNAs 474 mRNA/EST transcripts exhibited differential between...
The strategy of incorporating bioactive inorganic nanomaterials without side effects as osteoinductive supplements is promising for bone regeneration. In this work, a novel biomass nanofibrous scaffold synthesized by electrospinning silica (SiO2) nanoparticles into polycaprolactone/chitosan (PCL/CS) nanofibers was reported tissue engineering. nanosilica-anchored PCL/CS bioscaffold (PCL/CS/SiO2) exhibited an interlinked continuous fibers framework with SiO2 embedded in the fibers. Compact...
Neuroendocrine differentiation in prostatic carcinomas generally confers a more aggressive clinical behavior and less favorable prognosis than usual carcinomas. In this article, we report case of 65-year-old man with carcinoma who had metastasis the submandibular area. His serum prostate-specific antigen level was reduced to below normal range carcinoembryonic increased. Pathologic specimens demonstrated small cell neuroendocrine by immunohistochemical studies.
e18001 Background: The efficacy and safety of Pembrolizumab in recurrent /unresectable/metastatic head neck squamous cell carcinoma have been well documented KEYNOTE-048 other studies, the effectiveness different areas’ population shown related studies. However, there is no native data based on Chinese population. purpose this study was to investigate treatment R/U/M Methods: We reviewed patients from department Oral & Maxillofacial Surgery, Affiliated Hospital Qingdao University. with...