A5100324189- Cancer-related molecular mechanisms research
- Oral microbiology and periodontitis research
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Climate Change and Health Impacts
- Helicobacter pylori-related gastroenterology studies
- Air Quality and Health Impacts
- interferon and immune responses
- Gastrointestinal Tumor Research and Treatment
- Macrophage Migration Inhibitory Factor
- Head and Neck Cancer Studies
- Immune Response and Inflammation
- Thyroid Cancer Diagnosis and Treatment
- NF-κB Signaling Pathways
- Global Health Care Issues
- Neurofibromatosis and Schwannoma Cases
- Ubiquitin and proteasome pathways
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Healthcare and Venom Research
- Phagocytosis and Immune Regulation
- RNA regulation and disease
- Reconstructive Facial Surgery Techniques
Fu Jen Catholic University
2025
University of Oxford
2023-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Qingdao University
2015-2024
Medical Research Council
2023-2024
Central South University
2022-2024
University of Pennsylvania
2024
Putian University
2022-2023
Xi'an Jiaotong University
2022-2023
CRISPR/Cas12, a highly efficient and specific nucleic acid recognition system, has been broadly employed to detect amplified DNA products. However, most reported methods adopt two-step detection mode that needs liquid transfer step, thus complicating the procedure posing risk of aerosol contamination. A one-pot method can obviate these problems, but it suffers from poor efficiency due loss amplification templates elicited by CRISPR/Cas12 cleavage. In this study, we discovered glycerol...
Abstract It is critical to understand factors associated with nasopharyngeal carcinoma (NPC) metastasis. To track the evolutionary route of metastasis, here we perform an integrative genomic analysis 163 matched blood and primary, regional lymph node metastasis distant tumour samples, combined single-cell RNA-seq on 11 samples from two patients. The mutation burden, gene frequency, signature, copy number frequency are similar between metastatic tumours primary tumours. There distinct routes...
Prompt diagnosis of tuberculosis (TB) enables timely treatment, limiting spread and improving public health for this disease. Currently, a rapid, sensitive, accurate, cost-effective detection TB still remains challenge. For purpose, we engaged transmission skill an attenuated total reflectance (ATR) technique coupled with Fourier-transform infrared spectrometry (FTIR) to study the IR spectra plasma samples from patients (n = 10) healthy individuals 10). To ensure high-quality spectral data,...
Background The pathophysiological mechanisms of irritable bowel syndrome (IBS) are intricate, and associated with tryptophan metabolites. This study was designed to investigate the relationship between indole metabolites in feces intestinal function patients IBS. Methods In this study, 42 diarrhea-predominant IBS (IBS-D) 36 healthy controls were recruited. symptom severity evaluated using IBS-quality life (IBS-QOL) system (IBS-SSS). levels metabolite fecal samples determined by means mass...
This study was conducted to investigate the roles of different Toll-like receptor (TLR) signaling in Porphyromonas gingivalis (P. gingivalis)-induced and ligature-induced experimental periodontal bone resorption mice. Wild-type (WT), TLR2 knockout (KO), TLR4KO, TLR2&4 KO mice with C57/BL6 background were divided into three groups: control, P. infection, ligation. Live or silk ligatures placed sulcus around maxillary second molars over a 2-week period. Images captured by digital...
Paroxysmal nocturnal hemoglobinuria (PNH), a rare hematologic disease, is associated with high maternal and fetal mortality rates. Only 1 medication approved for PNH, the complement component 5 inhibitor eculizumab, has published evidence of use during pregnancy.
Objective: The oral microbiota plays a key part in the initial colonization by pathogens and chronic inflammatory reaction of host. We measured variations salivary microbiota, evaluated their potential associations with periodontitis obstructive pulmonary disease (COPD). Methods: investigated patients COPD (n = 21) compared that alone 36) healthy controls (HCs; n 14), using pyrosequencing polymerase chain reaction-amplified 16s rRNA genes. Results: Bacterial richness diversity were...
The purpose of this study was to investigate the effects vitamin D in rat models chronic obstructive pulmonary disease (COPD) and periodontitis. Animals with both periodontitis COPD, or only, were established. Once animal model established, experimental groups received intraperitoneal injections 25-hydroxyvitamin D3 (25-OHD3) for 8 weeks, while control refined peanut oil. After sacrifice, inflammatory status examined terms serum levels receptor activator nuclear factor κB ligand (RANKL),...
A chiral separation method of naringenin in citrus pulp and peel was established using ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) this study. The liquid-phase conditions for were Chiralpak IG-3 column at 40°C, mobile phase methanol, 0.1% formic acid solution (85/15; v/v). Isovolumetric elution can complete the detection within 5 min. Considering matrix effect, standard calibration curve used sample quantification. Quantitation achieved by fitting a matrix....