A5100349417- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Diet and metabolism studies
- Cardiac Fibrosis and Remodeling
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Signaling Pathways in Disease
- Diabetes Management and Research
- Respiratory Support and Mechanisms
- Obesity, Physical Activity, Diet
- Diabetes Treatment and Management
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Thyroid Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Nuclear Receptors and Signaling
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Neonatal Health and Biochemistry
First Affiliated Hospital of Dalian Medical University
2018-2025
China Medical University
2025
Wenzhou Medical University
2024
Dongyang People's Hospital
2024
Qilu Hospital of Shandong University
2019-2023
State Key Laboratory for Innovation and Transformation of Luobing Theory
2023
National Institute of Allergy and Infectious Diseases
2023
Capital Medical University
2019-2023
Dalian Medical University
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating diabetic cardiomyopathy (DCM) but been found to be a substrate of disintegrin and metalloprotease protein-17 (ADAM17). However, whether ADAM17 plays role the pathogenesis intervention DCM is obscure. In this study, we created cardiomyocyte-specific knockout (A17 α-MHCKO ) mice, left ventricular dimension, function, pathology molecular biology were assessed fl/fl control, A17 mice. Both differentiated H9c2...
Rationale:The rennin-angiotensin-aldosterone system (RAAS) plays a critical role in the pathogenesis of diabetic cardiomyopathy, but member RAAS, angiotensin IV (Ang IV), this disease and its underlying mechanism are unclear.This study was aimed to clarify effects Ang downstream mediator forkhead box protein O1 (FoxO1) on cardiomyopathy.Methods: In vivo, mice were treated with low-, medium-and high-dose IV, AT4R antagonist divalinal, FoxO1 inhibitor AS1842856 (AS), or their combinations.In...
Aminoglycosides exhibit ototoxicity by damaging mitochondria, which in turn generate reactive oxygen species that induce hair cell death and subsequent hearing loss. It is well known damaged mitochondria are degraded mitophagy, an important mitochondrial quality control system maintains homeostasis ensures survival. However, it unclear whether dysregulation of mitophagy contributes to aminoglycoside-induced injury. In the current study, we found PINK1-PRKN-mediated was impaired...
Cardiac fibrosis plays a key role in the progression of diabetic cardiomyopathy (DCM). Previous studies demonstrated cardioprotective effects natriuretic peptides. However, peptide receptor C (NPRC) on cardiac DCM remains unknown. Here, we observed that myocardial NPRC expression was increased mice and patients with DCM.
Abstract Previous studies suggested a beneficial effect of natriuretic peptides in animal models cardiovascular disease, but the role peptide receptor C (NPRC) pathogenesis atherosclerosis (AS) remains unknown. This study was designed to test hypothesis that NPRC may promote AS lesion formation and instability by enhancing oxidative stress, inflammation, apoptosis via protein kinase A (PKA) signaling. ApoE −/− mice were fed chow or Western diet for 12 weeks expression significantly increased...
Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity individuals at risk acquiring infectious diseases such as HIV. We used a rhesus macaque animal model optimize naturally-arising, autologous anti-SIV neutralizing antibodies expressed by Adeno-Associated Virus 8 (AAV8) vectors. Vectored transgene expression was confirmed quantitation target antibody abundance in serum mucosal surfaces. tested the achieved varying doses numbers injections....
Oblique lumbar interbody fusion (OLIF) is a minimally invasive technique performed through the antero-oblique trajectory to address wide range of pathologies. However, it can lead complications. We reviewed results OLIF and discussed effective methods avoid such complications.Seventy-nine consecutive patients who underwent between May 2016 July 2019 were retrospectively analyzed. They divided into three groups: stand-alone, posterior, lateral fixation, according whether they followed up with...
Elevated serum uric acid (SUA) is regarded as a risk factor for the development of cardiovascular diseases. Triglyceride-glucose (TyG) index, novel surrogate insulin resistance (IR), has been proven to be an independent predictor adverse cardiac events. However, no study specifically focused on interaction between two metabolic factors. Whether combining TyG index and SUA could achieve more accurate prognostic prediction in patients undergoing coronary artery bypass grafting (CABG) remains unknown.
Background Growing evidence suggesting a connection between the gut microbiome, plasma metabolites, and development of heart failure (HF). However, causality this relationship remains to be fully elucidated. Methods Utilizing summary statistics from extensive genome-wide association studies (GWAS), we investigated interplay among 1,400 metabolites failure. We conducted bidirectional Mendelian randomization (MR) analyses MR mediation analysis discern within these relationships. The inverse...
Disruptions in circadian rhythms are commonly observed patients with Alzheimer's disease (AD) and could potentially accelerate the progression of condition. However, relationship between rhythm disruptions AD development, as well mechanisms involved, remain poorly understood. This study investigated behavior, rhythmic gene expression multiple brain regions, its correlation sleep architecture mice at two stages: plaque-free stage (2-month-old) plaque-burdened (10-month-old) compared to...
Erythropoietin dose-dependently induces abdominal aortic aneurysm in mice via JAK2/STAT5 signaling, even without angiotensin II infusion.
To explore the chronic effects of metformin on testosterone levels in men with type 2 diabetes mellitus (T2DM). This is a secondary analysis real-world study evaluating efficacy and safety premixed insulin treatment patients T2DM via 3-month intermittent flash glucose monitoring. Male aged 18-60 who were using during period included as group. The control group males without therapy by propensity score matching age covariate. Testosterone measured at baseline after treatment. After treatment,...
Nuclear receptor related-1 (Nurr1), a ligand-activated transcription factor, is considered potential susceptibility gene for Parkinson's disease (PD), and has been demonstrated to possess protective effects against inflammation-induced neuronal damage. Despite the evidence showing decreased NURR1 level increased pro-inflammatory cytokines in cell animal models as well PD patients' peripheral blood mononuclear cells (PBMCs), underlying mechanism remains elusive. In this study, we investigated...
Vitamin D, whose levels vary seasonally with sunlight, is activated to 1α,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression. We genotyped VDR polymorphisms determined their associations midazolam pharmacokinetics, whether levels/activity varied seasonally. The BsmIG > A (rs1544410) polymorphism was significantly associated jejunal expression/activity, duodenal mRNA, area under curve (AUC). Intestinal...
Background. Our colleagues have demonstrated an impressive therapeutic role of sevoflurane in a murine allergic airway inflammation model, but the mechanisms underlying this effect remain undefined. In study, we tried to investigate on resolution and assess whether NLRP3 or inflammasome is involved process. Methods. Female (C57BL/6) mice were sensitized challenged with ovalbumin (OVA). Then, some received MCC950 (10 mg/kg; i.p.) 3% sevoflurane. Total differential inflammatory cell numbers,...
The deterioration of brain glucose metabolism predates the clinical onset Alzheimer’s disease (AD). Medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) positively improve decrease expression AD-related proteins. However, effects combined intervention are unclear. present study explored supplementation MCTs with DHA in improving decreasing protein levels APP/PS1 mice. mice were assigned into four dietary treatment groups: control group, + group. corresponding diet respective...
Abstract Objective This study aimed to investigate the responses of periodontal environment hormone replacement therapy (HRT) in postmenopausal women with or without periodontitis. Background HRT is a common and effective strategy for controlling menopausal symptoms, while changes under it, particularly periodontitis, remain unclear. Methods As prospective cohort study, total 97 receiving were screened, including 47 50 Correspondingly, did not screened as controls during same period. The...
Glucocorticoids are used universally in the remission induction therapy for acute lymphoblastic leukemia (ALL). One of adverse effects glucocorticoids is hypertension. Our aim was to define frequency and clinical genetic risk factors steroid-induced hypertension.We determined genotypes 203 candidate polymorphisms genes previously linked hypertension or pharmacokinetics pharmacodynamics antileukemic agents. Hypertension defined according guidelines American Academy Pediatrics; patients were...