A5077050236- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Vascular Malformations Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Lysosomal Storage Disorders Research
- Nerve injury and regeneration
- Cerebral Venous Sinus Thrombosis
- Brain Metastases and Treatment
- Sleep and Wakefulness Research
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Chromatin Remodeling and Cancer
- Peptidase Inhibition and Analysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related gene regulation
- Plant Gene Expression Analysis
- Health, Environment, Cognitive Aging
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Intracerebral and Subarachnoid Hemorrhage Research
- Extracellular vesicles in disease
Dalian Medical University
2020-2024
First Affiliated Hospital of Dalian Medical University
2021-2024
In non-small cell lung cancer (NSCLC), metastasis is the most common phenotype, and autophagy plays a vital role in its regulation. However, there are limited data on how autophagy-related genes metastasis-related affect NSCLC progression. Our goal was to identify that regulate NSCLC, assess underlying mechanisms this current study. RNA sequencing from public databases were used screen differentially expressed autophagy- metastasis-associated genes. Enrichment analyses immune correlations...
Nuclear receptor related-1 (Nurr1), a ligand-activated transcription factor, is considered potential susceptibility gene for Parkinson's disease (PD), and has been demonstrated to possess protective effects against inflammation-induced neuronal damage. Despite the evidence showing decreased NURR1 level increased pro-inflammatory cytokines in cell animal models as well PD patients' peripheral blood mononuclear cells (PBMCs), underlying mechanism remains elusive. In this study, we investigated...
Abstract Background Although WD repeat domain 45 (WDR45) mutations have been linked to $$\upbeta$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>β</mml:mi> </mml:math> -propeller protein-associated neurodegeneration (BPAN), the precise molecular and cellular mechanisms behind this disease remain elusive. This study aims shed light on impacts of WDR45-deficiency neurodegeneration, specifically axonal degeneration, within midbrain dopaminergic (DAergic) system. We hope...
Objective: To evaluate the altered expression of peripheral clock genes, circulating melatonin levels, and their correlations with sleep-wake phenotypes including probable rapid eye movement sleep behavior disorder (pRBD) symptoms in a relatively large population Parkinson's disease (PD) patients. Methods: We determined profiles five principal BMAL1, CLOCK, CRY1, PER1, PER2, blood mononuclear cells (PBMCs) PD patients (n = 326), healthy controls (HC, n 314) using quantitative real-time PCR....
Abstract Parkinson’s disease (PD) is characterized by the selective loss of dopaminergic neurons in midbrain and pathological accumulation misfolded α-synuclein (α-syn) brain. A growing body evidence suggests that formation α-syn aggregation may begin peripheral nervous system, specifically enteric then propagate to central system via vagus nerve. However, PD-like neuropathology induced intestine nerve extracts rarely investigated. In this work, we injected lysates obtained from a diagnosed...
The increasing prevalence of Alzheimer's disease and related dementias (ADRD) presents both a burden an opportunity for intervention. This study aims to estimate the impacts health insurance resources on attributed ADRD.
We evaluated the potential of Parkinson's disease (PD) fecal microbiota transplantation to initiate or exacerbate PD pathologies and investigated underlying mechanisms.
OPINION article Front. Neurosci., 03 January 2024Sec. Neurodegeneration Volume 17 - 2023 | https://doi.org/10.3389/fnins.2023.1334461
Neuroinflammation has long been thought to be associated with amyotrophic lateral sclerosis (ALS) development and progression. However, the exact molecular mechanisms of neuroinflammation underlying ALS remain largely unknown. In present study, we attempted elucidate genetic basis in by comparing transcriptomic profile anterior horns lumbar spinal cord (AHLSC) between SOD1 G93A mice their wild-type (WT) littermates. Our results revealed that immune-related genes were selectively up-regulated...
Parkinson's disease (PD) is pathologically characterized by progressive dopaminergic (DAergic) neuron loss in the substantia nigra pars compacta (SNpc) and accumulation of intracytoplasmic α-synuclein-containing Lewy bodies. Autophagy has been identified as a critical component development progression PD. Several autophagy genes have being altered One those genes, vacuole membrane protein-1 (VMP1), an protein localized endoplasmic reticulum (ER) DAergic neurons, shown to cause motor...
According to our prior findings, ARID1A expression is decreased in colon cancer, which has a poor prognosis. In this study, we investigated the ARID1A-VIM/CDH1 signalling axis's role cancer proliferation and migration. The differentially expressed genes cells that might be controlled by were discovered database screening for knockout. qPCR was used analyse EMT markers levels cancer. We utilized siRNA RID1A explore influence of silencing on CRC cells. function utilizing wound healing,...
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Background and Objective: Understanding the tumor microenvironment (TME) immune cell infiltration (ICI) may help guide immunotherapy efforts for colon cancer (COAD). However, whether ARID1B is truly regulated by hypermethylation or linked to remains unknown. The current work focused on gene expression methylation in COAD, as well its relation with ICI. Methods Results: Multiple tools based TCGA were used analyze differences of gene, DNA methylation, association various clinicopathological...