A5049031669- Graphene and Nanomaterials Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience and Neural Engineering
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Concrete and Cement Materials Research
- Graphene research and applications
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Planarian Biology and Electrostimulation
- Advanced ceramic materials synthesis
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Nanopore and Nanochannel Transport Studies
- MXene and MAX Phase Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- 3D Printing in Biomedical Research
- SARS-CoV-2 and COVID-19 Research
- Quantum Dots Synthesis And Properties
- interferon and immune responses
- Vestibular and auditory disorders
- Nanoparticles: synthesis and applications
- Photoreceptor and optogenetics research
- Plant Molecular Biology Research
Nantong University
2016-2025
Soochow University
2020-2025
Nanjing Tech University
2010-2025
Wenzhou Medical University
2025
Wuhan University
2007-2024
EarthTech International (United States)
2024
First Hospital of Jilin University
2024
Power Grid Corporation (India)
2024
Jilin University
2024
First Affiliated Hospital of Soochow University
2020-2023
Neural stem cell (NSC) based therapy provides a promising approach for neural regeneration. For the success of NSC clinical application, scaffold is required to provide three-dimensional (3D) growth microenvironments and appropriate synergistic guidance cues. Here, we report first utilization graphene foam, 3D porous structure, as novel NSCs in vitro. It was found that foams (3D-GFs) can not only support growth, but also keep at an active proliferation state with upregulation Ki67 expression...
Mitophagy, which is a conserved cellular process for selectively removing damaged or unwanted mitochondria, critical mitochondrial quality control and the maintenance of normal physiology. However, precise mechanisms underlying mitophagy remain largely unknown. Prior studies on focused events in outer membrane. PHB2 (prohibitin 2), highly membrane scaffold protein, was recently identified as novel inner receptor that mediates mitophagy. Here, we report new signaling pathway PHB2-mediated...
Aminoglycosides are toxic to sensory hair cells (HCs). Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that plays important roles in the maintenance of cellular function viability under stress. However, role autophagy aminoglycoside-induced HC injury unknown. Here, we first found activity was significantly increased, including enhanced autophagosome-lysosome fusion, both cochlear HCs HEI-OC-1 after neomycin or gentamicin injury, suggesting might be...
Engineered cardiac tissues (ECTs) derived from human induced pluripotent stem cells (hiPSCs) are viable alternatives for repair, patient-specific disease modeling, and drug discovery. However, the immature state of ECTs limits their clinical utility. The microenvironment fabricated using 3D scaffolds can affect cell fate, is crucial maturation ECTs. Herein, authors demonstrate an electric-field-driven (EFD) printed highly ordered microstructure with feature size to promote simulation...
Abstract Human 53BP1 is primarily known as a key player in regulating DNA double strand break (DSB) repair choice; however, its involvement other biological process less well understood. Here, we report previously uncharacterized function of at heterochromatin, where it undergoes liquid-liquid phase separation (LLPS) with the heterochromatin protein HP1α mutually dependent manner. Deletion results reduction centers and de-repression heterochromatic tandem repetitive DNA. We identify domains...
Abstract Integrating optically active components into chiral photonic cellulose to fabricate circularly polarized luminescent materials has transformative potential in disease detection, asymmetric reactions, and anticounterfeiting techniques. However, the lack of cellulose‐based left‐handed light (L‐CPL) emissions hampers progress these functionalizations. Here, this work proposes an unprecedented strategy: incorporating a nematic organization hydroxypropyl with robust aggregation‐induced...
Cisplatin can damage spiral ganglion neurons (SGNs) and cause sensorineural hearing loss. Wnt activation protects against neomycin-induced hair cell in the mouse cochlea, but role of signaling protecting SGNs from cisplatin treatment has not yet been elucidated. This study was designed to investigate neuroprotective effects cisplatin-induced SGN damage.First, we found that activated after treatment. Next, discovered overexpression (OE) reduced loss by inhibiting caspase-associated apoptosis,...
Calcium and integrin-binding protein 2 (CIB2) belongs to a family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Among the Cib1 Cib2 genes expressed in mouse cochlear hair cells, mutations human CIB2 gene have been associated nonsyndromic deafness DFNB48 syndromic USH1J. To further explore function of hearing, we established knockout mice using clustered regularly interspaced short palindromic repeat (CRISPR)-associated Cas9...
Foxg1 is one of the forkhead box genes that are involved in morphogenesis, cell fate determination, and proliferation, was previously reported to be required for morphogenesis mammalian inner ear. However, knock-out mice die at birth, thus role regulating hair (HC) regeneration after birth remains unclear. Here we used Sox2CreER/+ Foxg1loxp/loxp Lgr5-EGFPCreER/+ conditionally knock down specifically Sox2+ SCs Lgr5+ progenitors, respectively, neonatal mice. We found conditional knockdown...
Abstract Recent results from network theory show that complexity affects several dynamical properties of networks favor synchronization. Here we synchronization in 2D and 3D neuronal is significantly different. Using dissociated hippocampal neurons compared cultures grown on a flat substrates with those formed graphene foam scaffolds. Both had comparable glia to neuron ratio the percentage GABAergic inhibitory neurons. because their dimension have many connections among distant leading...
Aminoglycosides exhibit ototoxicity by damaging mitochondria, which in turn generate reactive oxygen species that induce hair cell death and subsequent hearing loss. It is well known damaged mitochondria are degraded mitophagy, an important mitochondrial quality control system maintains homeostasis ensures survival. However, it unclear whether dysregulation of mitophagy contributes to aminoglycoside-induced injury. In the current study, we found PINK1-PRKN-mediated was impaired...