A5035635459- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Scoliosis diagnosis and treatment
- Plant Toxicity and Pharmacological Properties
- Spinal Hematomas and Complications
- Shoulder Injury and Treatment
- Periodontal Regeneration and Treatments
- Pain Mechanisms and Treatments
- Orthopaedic implants and arthroplasty
- Anesthesia and Pain Management
- Spinal Cord Injury Research
- Ultrasonics and Acoustic Wave Propagation
- Bone and Joint Diseases
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
First Affiliated Hospital of Soochow University
2016-2025
Soochow University
2016-2025
Tongji University
2023-2025
Dazhou Central Hospital
2024
Shanghai Tenth People's Hospital
2023
Soochow University
2019
Texas A&M University
2016
Institute of Applied Technology
2015
University of California, Los Angeles
2001-2008
Hanalei Watershed Hui
2004
Abstract Successful regeneration of weight‐bearing bone defects and critical‐sized cartilage remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical physical properties have been rapidly developed as ideal candidates for tissue engineering scaffolds. Due to their unique advantages over other high specific‐surface areas, suitable mechanical strength, tailorable characteristics, scaffolds made fibers increasingly used...
Abstract Ideal cartilage tissue engineering requires scaffolds featuring good biocompatibility, large pore structure, high mechanical strength, as well minimal invasion procedure. Although significant progress has been made in the development of polymer scaffolds, construction smart systems with all desired properties is still emerging a challenge. The thermogels stereocomplex 4‐arm poly(ethylene glycol)–polylactide (PEG–PLA) (scPLA gel ) and cholesterol‐modified PEG–PLA (scPLA–Chol from...
Although degeneration of the nucleus pulposus (NP) is a major contributor to intervertebral disc (IVDD) and low back pain, underlying molecular complexity cellular heterogeneity remain poorly understood. Here, comprehensive single-cell resolution transcript landscape human NP reported. Six novel cells (NPCs) populations are identified by their distinct signatures. The potential functional differences among NPC subpopulations analyzed. Predictive transcripts, transcriptional factors, signal...
Kinetic MRIs of cervical spines were obtained and analyzed according to the amount motion degenerative grade intervertebral disc.To define relationship between disc degeneration unit spine elucidate changes in role each during flexion-extension caused by degeneration.Degenerative occur with age. The correlation degree extent mobility has not yet been determined. effect on overall functional spinal also remains undefined.We studied 164 patients symptomatic neck pain. discs graded surgeons...
In article number 1903279, Jin Zhang, Jianlin Zuo, Jun Zou, Jianxun Ding, and co-workers summarize the advances in preparation, composition, characteristics of polymer fibers, as well their applications bone cartilage tissue engineering, propose potential challenges opportunities.
Abstract Recent studies suggest that cell therapy may be an effective way to repair intervertebral disc degeneration. As a strong immune suppressor, TGF-β1 has been shown inhibit inflammation respond effectively. The objective of this study was explore the effects during bone marrow mesenchymal stem cells-based for In vitro assays demonstrated co-culturing nucleus pulposus cells with resulted in significantly higher levels TGF-βl secretion. This increase inhibited IκB phosphorylation and...
Inflammation, abnormal cholesterol metabolism, and macrophage infiltration are involved in the destruction of extracellular matrix nucleus pulposus (NP), culminating intervertebral disc degeneration (IDD). Whether nimbolide (Nim), a natural extract, can alleviate IDD is unclear. In this study, we demonstrated that Nim promotes efflux inhibits activation nuclear factor kappa B (NF-κB) mitogen-activated protein kinase (MAPK) signaling pathways by activating sirtuin 1 (SIRT1) cells (NPCs)...
This prospective, randomized study compared the functional outcome and complications associated with a proximal femoral nail antirotation (PFNA) device those of traditional extramedullary device, dynamic hip screw (DHS), in patients trochanteric fracture. A total 121 were to PFNA group ( n = 58) or DHS 63). Perioperative information recorded, assessments made. The required longer operative time was greater blood loss than group. re-operation rate lower group, especially unstable fractures,...
In Brief Study Design. The effect of postural change on degenerative lumbar discs was quantified using novel kinematic magnetic resonance imaging (kMRI). Objective. purpose is to describe the bulging intervertebral in vivo subjected different loads a kMRI. Summary Background Data. Symptomatic disc degeneration leading cause pain and disability throughout world. Over 70% US citizens will experience debilitating episode low back pain. Earlier reports changes are cadaver studies or performed...
Abstract Recent studies have suggested that platelet‐rich plasma ( PRP ) injections are an effective way to retard intervertebral disc degeneration, but the mechanism of action is unclear. Activated platelets release some growth factors, such as transforming factor‐β1 TGF ‐β1), which positively modulate extracellular matrix nucleus pulposus cells. The purpose this study was explore underlying ‐mediated inhibition degeneration. In in vitro study, we found proliferation cells greatly enhanced...
Intervertebral disc degeneration (IDD) and low back pain caused by IDD have attracted public attention owing to their extremely high incidence disability rate. Oxidative stress is a major cause of IDD. Tea polyphenols (TP) are natural-derived antioxidants extracted from tea leaves. This study explored the protective role TP on nucleus pulposus cells (NPCs) intervertebral discs underlying mechanism.An in vitro model H2O2-induced NPCs was established. RT-qPCR western blotting were used detect...
Cartilage regeneration is still a challenge for clinicians because of avascularity, denervation, load-bearing, synovial movement, and the paucity endogenous repair cells. We constructed multilayered osteochondral bionic scaffold examined its capacity using rabbit defect model. The cartilage phase interface layer were prepared by freeze-drying, whereas bone was high-temperature sintering. three-phase formed joining hydroxyapatite (HAp) silk fibroin (SF) scaffolds repeated freeze-thaw method....
Excessive reactive oxygen species (ROS) in nucleus pulposus cells (NPCs) promote extracellular matrix (ECM) degradation and cellular inflammatory responses by activating a variety of pathways, ultimately inducing cell apoptosis leading to the development low back pain. Here, we designed fabricated an isoginkgetin-loaded ROS-responsive delivery system (IGK@SeNP) based on diselenide block copolymers. Successfully encapsulated IGK was released intelligently rapidly microenvironment with high...
Although cigarette smoking (CS) and low back pain (LBP) are common worldwide, their correlations the mechanisms of action remain unclear. We have shown that excessive activation mast cells (MCs) proteases play key roles in CS-associated diseases, like asthma, chronic obstructive pulmonary disease (COPD), blood coagulation, lung cancer. Previous studies also MCs induce degenerative musculoskeletal disease. By using a custom-designed smoke-exposure mouse system, we demonstrated CS results...
Comparing the clinical and radiographic outcomes in anterior cervical discectomy fusion (ACDF) using a zero-profile anchored spacer (ROI-C) or conventional cage-plate construct (CPC) for treating noncontiguous bilevel of degenerative disc disease (CDDD).Overall, 46 patients with 2 segments CDDD, treated ACDF from January 2011 to October 2015, were included this study. ROI-C was used 22 (group A) CPC 24 B). The complications compared pre- postoperatively. All followed up at least months after...
Chronic low back pain (LBP) is a significant global health concern, often linked to vertebral bone marrow lesions (BML), particularly fatty replacement (FR). This study aims explore the relationship between gut microbiome, serum metabolome, and FR in chronic LBP patients. Serum metabolomic profiling microbiome analysis were conducted patients with without (LBP + FR, n = 40; LBP, 40) Healthy Controls (HC, 31). The investigates alterations branched-chain amino acids (BCAAs) levels identifies...
Abstract This article takes the sliding support structure of external window as research object and changes its to reduce mass stress concentration in order save materials while meeting structural requirements. Firstly, digital parameter model can be carried out using Creo 3D software, which allows parameters defined directly within range controlled by computer without need for manual modification component thickness. ANSYS software is used perform finite element simulation analysis on under...
Lumbar disc herniation (LDH) is a prevalent degenerative disorder frequently resulting in lumbar and leg pain. Obese patients with LDH often encounter the scenario where not completely resolved short term following percutaneous transforaminal endoscopic discectomy (PTED), necessitating subsequent surgical intervention, or long-term reherniation occurs post-procedure. Currently, literature provides little information regarding application of annulus fibrosus suture (AFS) as supplementary...