A5070623951- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Cerebral Venous Sinus Thrombosis
- Peripheral Nerve Disorders
- RNA regulation and disease
- Cancer Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Cancer Studies
- Plant Reproductive Biology
- Nerve injury and regeneration
- Ear and Head Tumors
- Neurological Disorders and Treatments
- Tracheal and airway disorders
- Garlic and Onion Studies
- Spinal Cord Injury Research
- Connexins and lens biology
- Hearing Loss and Rehabilitation
- Wnt/β-catenin signaling in development and cancer
- Neuroscience and Neural Engineering
- melanin and skin pigmentation
- Developmental Biology and Gene Regulation
- Antimicrobial Peptides and Activities
Shandong Provincial Hospital
2013-2024
Shandong University
2015-2024
Shandong Institute of Metrology
2022-2024
Shandong First Medical University
2023-2024
Jiujiang University
2010
Qilu Hospital of Shandong University
2005-2007
Spiral ganglion neurons (SGNs) are auditory that relay sound signals from the inner ear to brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead sensorineural hearing loss (SNHL), there currently no methods for preventing or treating this. Macroautophagy/autophagy plays a critical role in SGN development, but effect of autophagy on cisplatin-induced injury is unclear. Here, we first found autophagic flux was activated after damage. apoptosis related induced by were alleviated...
Cisplatin can damage spiral ganglion neurons (SGNs) and cause sensorineural hearing loss. Wnt activation protects against neomycin-induced hair cell in the mouse cochlea, but role of signaling protecting SGNs from cisplatin treatment has not yet been elucidated. This study was designed to investigate neuroprotective effects cisplatin-induced SGN damage.First, we found that activated after treatment. Next, discovered overexpression (OE) reduced loss by inhibiting caspase-associated apoptosis,...
Hearing loss is the most common sensory disorder in humans, and a significant number of cases due to ototoxicity drugs such as cisplatin that cause hair cell (HC) damage. Thus, there great interest finding agents mechanisms protect HCs from ototoxic drug It has been proposed epigenetic modifications are related inner ear development play role HC protection regeneration; however, whether m6A modification ethyl ester form meclofenamic acid (MA2), which highly selective inhibitor FTO (fatmass...
Ménière's disease, a multifactorial disorder of the inner ear, is characterized by severe vertigo episodes and hearing loss. Although role immune responses in disease has been proposed, precise mechanisms remain undefined. Here, we show that downregulation serum/glucocorticoid-inducible kinase 1 associated with activation NLRP3 inflammasome vestibular-resident macrophage-like cells from patients. Serum/glucocorticoid-inducible depletion markedly enhances IL-1β production which leads to...
Whole organ culture of the spiral ganglion region is a resourceful model system facilitating manipulation and analysis live sprial neurons (SGNs). Three-dimensional (3D) cultures have been demonstrated to many biomedical applications, but effect 3D in maintaining SGNs structure function explant remains uninvestigated. In this study, we used matrigel encapsulate isolated from neonatal mice. First, optimized concentration for found protected against apoptosis, preserved region, promoted...
Abstract c-Myb is a transcription factor that plays key role in cell proliferation, differentiation, and apoptosis. It has been reported expressed within the chicken otic placode, but whether exists mammalian cochlea, how it exerts its effects, not explored yet. Here, we investigated expression of postnatal mouse cochlea HEI-OC1 cells found was hair (HCs) as well cultured cells. Next, demonstrated decreased response to neomycin treatment both cochlear HCs cells, suggesting an otoprotective...
Abstract Meniere’s disease (MD) is a disorder of the inner ear characterized by episodes spontaneous vertigo, fluctuating hearing loss, and tinnitus. Recent studies have demonstrated that IgE may play role in pathogenesis MD. Patients with MD (n = 103), acoustic neuroma 5), healthy subjects 72) were recruited into study. Serum from participants was analyzed for type 2–related cytokines. CD23 expression levels vestibular end organs patients, C57BL/6 mice, or mouse HEI-OC1 cells analyzed....
INTRODUCTION:Meniere's disease is a common chronic inner ear disease. Because the definitive pathogenesis still unknown, there currently no cure for this disorder. Semicircular canal plugging (SCP), first used to treat patients with intractable benign paroxysmal positional vertigo, has since been applied peripheral vertigo. This study was aimed explore long-term efficacy of triple semicircular (TSCP) in treatment Meniere's (MD) so as provide new method framework MD. METHODS:Three hundred and...
Objectives The study goals were to compare the long‐term efficacy of semicircular canal plugging (SCP) with labyrinthectomy in treatment advanced Meniere's disease (MD). Study Design A retrospective study. Setting Single tertiary medical center. Methods total 116 MD patients (TSCP group 90; 26) complete documents Shandong Provincial ENT Hospital, from March 2017 2019 retrospectively analyzed, including a battery auditory and vestibular function tests, recovery time imbalance level scores...
Abstract Purpose This retrospective cohort study aimed to investigate the effect of minimally invasive cochlear implantation (CI) on vestibular function (VF) and residual hearing (RH) as well their relationship in pediatric recipients before after surgery. Methods Twenty-four patients with preoperative low frequency (LFRH) (250 or 500 Hz ≤ 80 dB HL) who underwent CI were enrolled. Pure-tone thresholds, cervical/ocular vestibular-evoked myogenic potential (cVEMP/oVEMP), video head impulse...
Abstract Ménière’s disease (MD) is a complex inner ear disorder characterized by range of symptoms, with its pathogenesis linked to immune-related mechanisms. Our previous research demonstrated that IL-1β maturation and release can trigger cell pyroptosis, exacerbating the severity endolymphatic hydrops in mouse model; however, specific mechanism through which influences MD symptoms remains unclear. This study conducted on patients examined changes protein signatures vestibular end organs...
Objective We investigated correlations among clinical features, degree of inner ear endolymphatic hydrops (EH), and hippocampal volume (HV) in different stages Meniere's disease (MD). Methods From February 2021 to April 2022, data were collected from 99 patients (39 males, 60 females, mean age: 50.4 ± 10.0 [range: 26–69] years) with unilateral MD admitted the Department Vertigo Disease Shandong ENT Hospital. The left right ears affected 64 35 patients, respectively. There 50 49 cases early...
TSCP, which can reduce vertiginous symptoms in patients with intractable MD, represents an effective therapy for this disorder.To explore the long-term efficacy of triple semicircular canal plugging (TSCP) treatment Meniere's disease (MD).Seventy-nine diagnosed unilateral MD referred to a vertigo clinic hospital between December 2010 and 2013 were included study retrospective analysis. TSCP was performed affected ear each patient. Vertigo control auditory function measured. Pure tone...
Neurotrophic factors have been implicated in hyperalgesia and peripheral levels of these molecules are altered migraine pathophysiology. Artemin, a vasculature-derived neurotrophic factor, contributes to pain modulation trigeminal primary afferent sensitization through binding its selective receptor GFRα3. The distribution artemin GFRα3 the dura mater raises an anatomy supports that they may be involved migraine. In this study we evaluated expression animal model relevant for migraine.In...
In this cohort of 156 non-syndromic hearing-impaired subjects Tengzhou area, the most common deafness-associated genes GJB2, SLC26A4 and mtDNA 12S rRNA were investigated by SNPscan efficiently. GJB2 c.235delC c.IVS7-2A > G mutation sites.Until now, there is no systematic gentic analysis in patients with hearing loss for so we evaluated molecular etiology to investigate hot-sports.Peripheral blood samples obtained from severe-to-profound deafness Tengzhou. The SNP scan assay technique was...
BACKGROUND: To date, systematically objective evaluations of vestibular function in children with cochlear implantation (CI) have been conducted sparsely, especially large aqueduct syndrome (LVAS). OBJECTIVE: Our goal was to investigate the all five end-organs pre- and post-cochlear LVAS normal CT. METHODS: In this retrospective cohort study, 34 (age 4–17 years) bilateral profound sensorineural hearing loss (SNHL) undergoing unilateral CI were included. Participants included 18 (52.9%) LVAS....
Objectives: The present study was designed to determine whether or not the caspase-independent apoptotic pathway participated in cellular death of spiral ganglion neurons (SGNs) after exposure peroxynitrite (ONOO−), with particular attention given intranuclear translocation mitochondrial apoptosis-inducing factor (AIF) and endonuclease G (Endo G) this process.Methods: rat SGNs were isolated primary cultured vitro exposed ONOO− pre-treatment pan-caspase inhibitor. Morphological changes...
Conclusion SM-induced dose- and location-dependent cochlear hair cell death in vitro. AIF might be translocated from mitochondria to nucleus cytoplasm within SM-treated cells. The translocation of modulated by PARP-1.Objective Streptomycin (SM), one the widely used aminoglycoside nowadays, is still causing significant permanent sensorineural hearing loss owing sensory death. This study was designed investigate role apoptosis-inducing factor (AIF), an important mitochondrial regulator, SM...