A5101898195- Ear Surgery and Otitis Media
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- Tracheal and airway disorders
- Circular RNAs in diseases
- Advanced Glycation End Products research
- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Sinusitis and nasal conditions
- RNA modifications and cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Salivary Gland Tumors Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
- Redox biology and oxidative stress
- Biosensors and Analytical Detection
- Lung Cancer Research Studies
- Enzyme function and inhibition
- Melanoma and MAPK Pathways
- PI3K/AKT/mTOR signaling in cancer
- Moyamoya disease diagnosis and treatment
- Nicotinic Acetylcholine Receptors Study
- Metabolomics and Mass Spectrometry Studies
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
Huazhong University of Science and Technology
2003-2023
Wenzhou Medical University
2002-2021
First Affiliated Hospital of Wenzhou Medical University
2002-2021
Lanzhou University
2020
Lanzhou University Second Hospital
2020
ZheJiang Academy of Agricultural Sciences
2020
Creative Commons
2019
Wuhan No.1 Hospital
2018
Hearing loss is the most common sensory disorder in humans, and a significant number of cases due to ototoxicity drugs such as cisplatin that cause hair cell (HC) damage. Thus, there great interest finding agents mechanisms protect HCs from ototoxic drug It has been proposed epigenetic modifications are related inner ear development play role HC protection regeneration; however, whether m6A modification ethyl ester form meclofenamic acid (MA2), which highly selective inhibitor FTO (fatmass...
Abstract Targeting the ubiquitin-proteasome degradation pathway has become a promising approach for cancer therapy. Previous studies have shown that proteasome inhibition leads to apoptosis in various cells. The mechanism by which occurs are not fully understood and can be cell type and/or inhibitor specific. In this study, we investigated of mitochondrial activation inhibitors colon We found Bax mitochondria translocation were required induced multiple inhibitors. contrast, reactive oxygen...
Reactive oxygen species (ROS) are generated under various pathological conditions such as renal ischemia/reperfusion (I/R) injury and provoke damage to multiple cellular organelles processes. Overproduction of ROS causes oxidative stress contributes damages proximal tubular cells (PTC), which the main cause pathogenesis I/R injury. Autophagy is a dynamic process that removes long-lived proteins damaged via lysosome-mediated degradation, has an antioxidant effect relieves stress. The...
Abstract The application of network formulaology and pharmacology has significantly advanced the scientific understanding traditional Chinese medicine (TCM) treatment mechanisms in disease. field herbal biology is experiencing a surge data generation. However, researchers are encountering challenges due to fragmented nature reliance on programming tools for analysis. We have developed TCMNPAS, comprehensive analysis platform that integrates formularology pharmacology. This designed...
Abstract Aiming at the problems of uneven production schedule and low efficiency in assembly process aircraft doors a civil company, original door line was modeled simulated FlexSim to analyze reasons for above problems. Depending on constraints, blockage can be mitigated by adding or removing operators, merging stations, introducing automated equipment. Due large footprint automation equipment, lack buffer area, existing layout is insufficient meet requirements. Therefore, based system...
Lgr5+ cochlear supporting cells (SCs) have been reported to be hair cell (HC) progenitor that the ability regenerate HCs in neonatal mouse cochlea, and these are regulated by Wnt signaling. Frizzled-9 (Fzd9), one of receptors, has used mark neuronal stem brain together with other markers mesenchymal from human placenta bone marrow. Here we Fzd9-CreER mice lineage label trace Fzd9+ postnatal cochlea order investigate characteristic cells. Lineage labeling showed inner phalangeal (IPhCs),...
The epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells plays a key role in proliferative vitreoretinopathy (PVR) and diabetic retinopathy (PDR), both which lead to severe loss vision. Recently, microRNAs (miRNAs) have been found be involved the regulation various physiological pathological processes, such as embryogenesis, organ development, oncogenesis angiogenesis. However, expression profile function miRNAs EMT RPE remain clarified. In this study, human...
Tasisulam is a promising antitumor agent with complex pharmacology, which used as an antiproliferative in patients metastatic melanoma and other solid tumors. Phase 2 studies showed results but had to be stopped because of insufficient tasisulam clearance leading toxic side effects. To reduce the negative effects tasisulam, we synthesized novel sulfonimidamide-based analog evaluate its comparison original compound by performing cell proliferation assay lines SKMel23 A375. The revealed that...
The death receptor apoptosis pathway is intimately connected with the mitochondrial pathway. Bid a BH3-only pro-death Bcl-2 family protein and major molecule linking two pathways. Bid-mediated activation occurs early responsible for prompt progress of tumor necrosis factor alpha (TNF-alpha)-induced apoptosis. However, in both cultured cells animal models TNF-alpha-induced injury, later-phase Bid-independent could be demonstrated. Consequently, bid-deficient mice are still susceptible to...
Human osteosarcoma is the most common primary bone malignancy sarcoma that affects primarily children and people <20 years old. In present study, it was demonstrated miR‑574‑3p downregulated in human U2OS, SAOS MG63 cells lines as well tissue compared with normal tissues. Downregulation of by antisense miR‑574‑3p, inhibited cell growth induced apoptosis. Overexpression transfection mimics promoted U2OS cells. The study then identified mothers against decapentaplegic homolog 4 (SMAD4) a...
Chronic rhinosinusitis (CRS) is a form of chronic inflammation the nasal cavity and paranasal sinus with multi‑causal pathogenesis, including oxidative stress. Several lines evidence have demonstrated that phosphatase tensin homolog gene (PTEN) can inhibit activation phosphoinositide 3‑kinase (PI3K) to affect phosphorylation Akt. Importantly, PI3K/PTEN/Akt signaling pathway associated various types tumors, inflammatory diseases, autoimmune disease through its regulation cell growth,...
Background: Acellular dermal allograft (AlloDerm) and cartilage perichondrium are two common materials used for repair of tympanic membrane perforations (TMPs). To date, comparative evaluations their efficacy have rarely been reported.Aim/objectives: compare anatomical audiological outcomes between AlloDerm in type I tympanoplasty.Methods: A total 61 patients TMP were studied. In total, 27 (Group 1) underwent myringoplasty, the remaining 34 2) myringoplasty. Operating time, closure rate...
Abstract Isocitrate dehydrogenase 2 (IDH2) is a key enzyme in the regulation of cell metabolism. Its mutated type can lead to accumulation 2‐hydroxyglutarate, which often related malignancies such as acute myeloid leukemia. Therefore, it necessary find new inhibitors targeting mutant IDH2. Discriminatory analysis‐based molecular docking was employed screen ChemDiv compound library, resulted identification three IDH2 R140Q with moderate‐to‐good IC 50 values. Among them, compounds 1 and 3...
Background Long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. Vocal cord leukoplakia is a precancerous lesion otolaryngological practice. Till now, the expression patterns and functions of lncRNAs vocal have not been well understood. In this study, we used microarrays to investigate aberrantly expressed mRNAs adjacent non-neoplastic tissues. Methods Gene Ontology pathway analyses were performed determine significant function pathways differentially mRNAs. qRT-PCR was...
Background Staphylococcus aureus is the most commonly isolated bacterium from patients with surgically recalcitrant chronic rhinosinusitis (CRS). Understanding immune responses to S biofilms will provide insights into how host response may be manipulated by therapeutic agents improve chances of successfully preventing and treating these infections. In this study, we investigated inflammatory in a rabbit model biofilm–related sinusitis analyzing levels some major cytokines. Methods Eighteen...