Landoltia punctata is a widely distributed duckweed species with great potential to accumulate enormous amounts of starch for bioethanol production. We found that L. can rapidly accompanied by alterations in endogenous hormone levels after uniconazole application, but the relationship between hormones and accumulation still unclear. After spraying fronds 800 mg/L uniconazole, quickly, dry weight content up 48% 240 h growth compared 15.7% control group. Electron microscopy showed granule was...

Reactive oxygen species (ROS) are generated under various pathological conditions such as renal ischemia/reperfusion (I/R) injury and provoke damage to multiple cellular organelles processes. Overproduction of ROS causes oxidative stress contributes damages proximal tubular cells (PTC), which the main cause pathogenesis I/R injury. Autophagy is a dynamic process that removes long-lived proteins damaged via lysosome-mediated degradation, has an antioxidant effect relieves stress. The...

Incidence and mortality of prostate cancer (PCa) rank in the top five among male tumors. However, single treatment modalities are often restricted due to biochemical recurrence drug resistance, necessitating development new approaches for combination castration-resistant neuroendocrine PCa. Ferroptosis is characterized by accumulation iron-overload-mediated lipid peroxidation has shown promising outcomes anticancer treatment, prompting us present a review reporting application ferroptosis...

As the fastest growing plant, duckweed can thrive on anthropogenic wastewater. The purple-backed duckweed, Landoltia punctata, is rich in starch and flavonoids. However, molecular biological basis of high flavonoid low lignin content remains largely unknown, as does best method to combine nutrients removed from sewage utilization value improvement biomass. A combined omics study was performed investigate biosynthesis metabolic flux changes L. punctata grown different culture medium....

Oxidative stress and chronic inflammation are major culprits of nonalcoholic fatty liver disease (NAFLD). MicroRNA-665-3p (miR-665-3p) is implicated in regulating oxidative stress; however, its role molecular basis NAFLD remain elusive. Herein, we measured a significant upregulation miR-665-3p level the primary hepatocytes upon high fat diet (HFD) or 0.5 mmol/L palmitic acid plus 1.0 oleic stimulation, elevated expression aggravated stress, progression mice. In contrast, inhibition by...

Ginger ( Zingiber officinale Roscoe), a perennial herb, is one of the most economically valuable plants in Zingiberaceae family. Gingerol, as major constituents ginger essential oil, contributes to unique flavor and pharmaceutical value ginger. However, pathway gingerol biosynthesis has not been verified described help understand secondary metabolites nonmodel species. In this study, concentrations gingerols were quantified at different stages rhizome development tissues. The results...

Direct 3D printing of liquid metal is difficult to form and easy destroy. In this paper, we developed a printed composite material consisting thermoplastic polyurethane (TPU) matrix (LM) dispersed droplets, introduced the method for realizing devices with material: First, LM added 10~50wt %TPU at 190~200 °C through ultrasonic blending prepare blended ink. After solid cooling, LM-TPU fiber diameter 600 μm was prepared by Wellzoom desktop extruder 190 an extrusion speed 400 mm/min. It has...

For patients exhibiting non-small-cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutations, tyrosine kinase inhibitors (EGFR-TKIs) are a first-line treatment. However, most who initially responded to EGFR-TKIs eventually developed acquired resistance, limiting the effectiveness of therapy. It has long been known that epithelial-mesenchymal transition (EMT) leads resistance in NSCLC. mechanisms underlying dependent on EMT unknown. This research aimed reveal...

In recent years, several industries have increased their demand for processing precision, automatic detection, and visualization interfaces. Therefore, to keep pace with the fourth industrial revolution, machine tool operators install a large number of sensors on tools obtain more precise physical quantities during use variety measurements in various situations. However, these additional result complicated wire layouts, which exhibit negative effects processing. Such problems lead birth...

This paper presents an Adaboost algorithm based cutting data analysis for chatter detection. offline uses the vibration collected by accelerometers attached to spindle housing. A comparison of accuracy achieved with support vector machine, Random Forest, 1D Convolutional Neural Networks and Multilayer Perceptron is also made. In this paper, accelerometer are transformed into bandwidth. Time-accelerometer time-spectral bandwidth learning models built in order realize detection automated...

Despite an increasing appreciation of the importance host–microbe interaction in healthy growth, information on gut microbiota changes Chinese giant salamander ( Andrias davidianus ) during growth is still lacking. Moreover, it interesting to identify microbial structure for further monitoring A. health. This study explored composition and functional characteristics bacteria different periods, including tadpole stage (ADT), gills internalization (ADG), 1 year age (ADY), 2 (ADE), 3 (ADS),...

To share our experience in the diagnosis and treatment of an inflammatory myofibroblastic tumor urinary bladder (IMTUB).A database searches pathology archives by using term "inflammatory tumor" and" bladder" hospital department from 2010 to 2021. Patient characteristics, clinical features, histopathological results, immunohistochemical staining outcomes were reviewed.Fourteen cases IMTUB retrieved. The mean age was 44.7 ± 18.9 years (range 12-74). Nine (64.3%) patients presented with...

Background Cytochrome P450s play crucial roles in various biosynthetic reactions. Ginger ( Zingiber officinale ), which is often threatened by Ralstonia solanacearum , the most economically important crop family Zingiberaceae. Whether cytochrome P450 complement (CYPome) significantly responds to this pathogen has remained unclear. Methods Transcriptomic responses R. and soil moisture were analyzed ginger, expression profiles of CYPome determined based on transcriptome data. Results A total...

Prostate cancer (PC) is one of the most critical cancers affecting men's health worldwide. The development many involves dysregulation or mutations in key transcription factors. This study established a factor-based risk model to predict prognosis PC and potential therapeutic drugs.In this study, RNA-sequencing data were downloaded analyzed using Cancer Genome Atlas dataset. A total 145 genes related overall survival rate patients screened univariate Cox analysis. Kdmist clustering method...

Abstract Nonalcoholic fatty liver disease (NAFLD) poses serious threats to humans. Several studies have studied the biomarkers associated with NAFLD; however, results vary because of differences in sequencing platform, sample selection, and filter conditions. This study aimed explore key microRNAs (miRNAs) NAFLD by a systematic bioinformatics analysis. A total 10 qualified miRNA data sets were selected through literature review. Signature miRNAs identified overlap comparison. The target...

This study aims to explore the toxicity mechanism of Rhododendri Mollis Flos(RMF) based on serum metabolomics and network toxicology. The toxic effect RMF normal rats was evaluated according symptoms, biochemical indexes, histopathology. Serum combined with multivariate statistical analysis search endogenous differential metabolites related metabolic pathways. components, targets, signaling pathways were screened by toxicology technique, component-target-metabolite-metabolic pathway...

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases worldwide and can develop to nonalcoholic steatohepatitis later hepatic cirrhosis with a high prevalence hepatocellular carcinoma. Oxidative stress inflammation are implicated in pathogenesis NAFLD. MicroRNA-137-3p (miR-137-3p) associated oxidative inflammation; however, its role mechanism NAFLD remain unclear. Mice were fed high-fat diet (HFD) for 24 weeks establish model. To overexpress or suppress...

Abstract Background This study aimed to assess the impact of coronavirus disease 2019 (COVID-19) on hospital service utilization and revenue in Chinese tertiary hospitals develop an optimal pandemic control strategy (OPCS) for peak period Omicron wave. Methods Retrospective data from three (provincial, city, county level) were analyzed phases: pre-outbreak (Jan-Apr 2019), outbreak 2020), post-outbreak 2021). OPCS was developed under guidance China government policy during post-break phase...