A5070203415- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- Urologic and reproductive health conditions
- RNA Interference and Gene Delivery
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Cancer-related gene regulation
- Renal cell carcinoma treatment
- Dendrimers and Hyperbranched Polymers
- Immunotherapy and Immune Responses
- Minimally Invasive Surgical Techniques
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Pelvic floor disorders treatments
- Microtubule and mitosis dynamics
- Radiopharmaceutical Chemistry and Applications
- Ubiquitin and proteasome pathways
Sun Yat-sen University
2016-2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2018-2025
Shanghai Jiao Tong University
2025
Youjiang Medical College for Nationalities
2024
North Sichuan Medical University
2018-2020
Nanchong Central Hospital
2020
Education University of Hong Kong
2020
Dalian Medical University
2019-2020
Second Affiliated Hospital of Chongqing Medical University
2019-2020
Chongqing Medical University
2019-2020
Background Risk and crisis communication plays an essential role in public health emergency responses. The COVID-19 pandemic has triggered spontaneous intensive media attention, which affected people’s adoption of personal preventive measures their mental health. Objective aim this study was to investigate the associations between exposure COVID-19–specific information (depression sleep quality) self-reported compliance with (face mask wearing hand sanitizing). We also tested whether these...
Clear cell renal carcinoma (ccRCC) is one of the most common malignancies urinary system. Patient outcomes are relatively poor due to lack early diagnostic markers and resistance existing treatment options. Programmed death, also known as apoptosis, a highly regulated orchestrated form death that occurs ubiquitously throughout various physiological processes. It plays crucial role in maintaining homeostasis balance cellular activities. The combination immune checkpoint inhibitors plus...
Association of cigarette use with risk prostate cancer remains unclear. We performed this study to examine whether is associated increased cancer. This cross-sectional used data from the 1999 2020 National Health and Nutrition Examination Survey (NHANES), a population-based nationally representative survey designed assess health nutritional status US adults children. Males were eligible if they aged ≥ 20 years at time participation. Cigarette (ever use, categorized into former current use)...
Current predictive tools and imaging modalities are not accurate enough for preoperative diagnosis of lymph node metastatic prostate cancer (LNM PCa). Proteomic analysis is introduced to screen potential biomarkers early detection LNM PCa. In our initial study, protein samples from localized PCa as well benign prostatic hyperplasia tissues were analyzed using two-dimensional fluorescence difference in gel electrophoresis (2-D DIGE) coupled with MALDI-TOF/TOF MS. We identified 58 proteins...
Incidence and mortality of prostate cancer (PCa) rank in the top five among male tumors. However, single treatment modalities are often restricted due to biochemical recurrence drug resistance, necessitating development new approaches for combination castration-resistant neuroendocrine PCa. Ferroptosis is characterized by accumulation iron-overload-mediated lipid peroxidation has shown promising outcomes anticancer treatment, prompting us present a review reporting application ferroptosis...
Abstract Abnormal lipid metabolism and accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely linking such within RCC cells consequent tumorigenesis, the mechanisms underlying this process remain incompletely understood. In study, a series bioinformatics analyses were initially performed by screening databases gene sets, ultimately leading to identification TRIB3 as an oncogene that functions central regulator metabolism. overexpression...
We would like to express our thanks and appreciation the individuals who participated in NHANES staff made this research possible.
Schematic illustration of the development long-circulating pH-responsive polysaccharide–DOX prodrug nanoparticles for antitumor applications.
Abstract Multifactor and multistep processes were elucidated to participate in the progression of non‐small‐cell lung cancer (NSCLC). Circular RNA 0031250 (circ‐PRMT5) was a vital factor NSCLC. However, role circ‐PRMT5 cisplatin (DDP)‐resistance needed be further highlighted. Expression profiles circ‐PRMT5, microRNA (miR)‐4458, EV3‐like DNA‐directed polymerase ζ catalytic subunit (REV3L) detected using quantitative real‐time chain reaction....
Abstract Androgen receptor (AR) signaling inhibitors provide limited survival benefits to patients with prostate cancer (PCa), and worse, few feasible genomic lesions restrict targeted treatment PCa. Thus, a better understanding of the critical dependencies PCa may enable more therapeutic approaches dilemma. We performed kinome-scale CRISPR/Cas9 screen identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for cell survival. Suppression CDK12 by covalent inhibitor...
Metabolic dysfunction is seen in cancer cells where increased glycolysis provides energy for growth. Circular RNAs (circRNAs) are thought to assist glucose metabolism and the switch glycolysis. Through screening, we found that circVAMP3 was necessary both glycolytic proliferative activities renal cell carcinoma (RCC). Furthermore, expression elevated RCC patients correspondence with TNM stage. Mechanistically, observed interact directly lactate dehydrogenase A (LDHA) modulate its activity....
Combination therapy has emerged as a promising approach for treating tumors, although there is room improvement. This study introduced novel strategy that combined the enhancement of apoptosis, ferroptosis, and DNA damage to improve therapeutic outcomes prostate cancer. Specifically, we have developed supramolecular oxidative stress nanoamplifier, which was comprised β-cyclodextrin, paclitaxel, ferrocene-poly(ethylene glycol). Paclitaxel within system disrupted microtubule dynamics, inducing...
// Ke Li 1, * , Jun Pang Huaiyan Cheng 2, Wei-Peng Liu 3 Jin-Ming Di 1 Heng-Jun Xiao Yun Luo Hao Zhang Wen-Tao Huang Ming-Kun Chen Liao-Yuan Chun-Kui Shao 4 Ying-Hong Feng 2 Xin Gao Department of Urology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China Pharmacology, Uniformed Services University Health Sciences, Bethesda MD20814, USA First Hospital Nan Chang Nanchang 330006, Pathology, These authors have contributed equally to this work Correspondence to: Gao,...