A5100343470- Prostate Cancer Treatment and Research
- Total Knee Arthroplasty Outcomes
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Urological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Urinary Bladder and Prostate Research
- Orthopaedic implants and arthroplasty
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Atherosclerosis and Cardiovascular Diseases
- Sexual function and dysfunction studies
- Migraine and Headache Studies
- Cancer Research and Treatments
- Inflammatory mediators and NSAID effects
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
Third Affiliated Hospital of Sun Yat-sen University
2015-2025
Sun Yat-sen University
2015-2025
Chongqing Medical University
2014-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Municipal Health Commission
2025
Kunming Medical University
2025
Tianjin University of Science and Technology
2023-2025
Capital Medical University
2015-2024
Sichuan University
2015-2024
State Key Laboratory of Oral Diseases
2024
The development of minimally invasive cardiac patches, either as hemostatic dressing or treating myocardial infarction, is clinical significance but remains a major challenge. Designing such patches often requires simultaneous consideration several material attributes, including bioabsorption, non-toxicity, matching the mechanic properties heart tissues, and working efficiently in wet dynamic environments. Using genetically engineered multi-domain proteins, printed bi-layer proteinaceous...
Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and loss of mobility. Accumulating evidence indicates that incidence severity OA increases with diabetes, implicating systemic glucose metabolism in health. However, a definitive link between cellular articular pathogenesis not yet established. Here, we report mice surgically induced to develop knee through destabilization medial meniscus (DMM), expression main transporter Glut1 notably reduced cartilage....
A series of novel cyclopropylamide analogues combretastatin-A4 (CA-4) were designed and synthesized. Most them had significant in vitro antiproliferative activities, particularly for compounds 7i4, 7c4, 8a4, 8c4. Moreover, compound 8c4 was also equally potent against paclitaxel resistant cancer cells. Interestingly, the different binding mechanisms from CA-4. Instead inhibiting tubulin polymerization, these CA-4 derivatives able to stimulate polymerization. Flow cytometry revealed that...
Hepatic ischemia/reperfusion (I/R) injury is a major cause of high morbidity and mortality after liver resection, transplantation, hemorrhagic shock. Paeoniflorin (PF), the main substance glucosides in Radix Paeoniae Alba , has been widely used to treat various hepatic inflammatory diseases including I/R injury. However, underlying mechanisms PF on remain further investigated. In this study, model was performed by clamping portal vein artery with an atraumatic clamp for 90 min followed 6 hr...
ABSTRACT Five OXA-232 carbapenemase-producing Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproduced bla CTX-M-15 SHV-1 genes. All isolates resistant ertapenem (MICs of >32 μg/ml) meropenem 4 8 susceptible or intermediate imipenem 1 2 μg/ml). The gene was located on a ColE-type transformable plasmid 6,141 bp. To best our knowledge, this is first report carbapenemase among clinical in China.
Postoperative delirium (POD) is a common complication following surgery and anesthesia (Surgery/Anesthesia). Mitochondrial dysfunction, which demonstrated by energy deficits excessively activated oxidative stress, has been reported to contribute POD. The dynamic balance between mitochondrial fusion fission processes critical in regulating function. However, the impact of Surgery/Anesthesia on fusion/fission dynamics remains unclear. Here, we evaluate effects laparotomy under 1.4% isoflurane...
Alternative polyadenylation (APA), a posttranscriptional mechanism of gene expression via determination 3'UTR length, has an emerging role in carcinogenesis. Although abundant APA reprogramming is found kidney renal clear cell carcinoma (KIRC), which one the major malignancies, whether functions KIRC remains unknown. Herein, we that chromatin modifier MORC2 gained oncogenic potential among genes with reprogramming, and moreover, its was enhanced by shortening through stabilization mRNA. to...
// Ke Li 1, * , Jun Pang Huaiyan Cheng 2, Wei-Peng Liu 3 Jin-Ming Di 1 Heng-Jun Xiao Yun Luo Hao Zhang Wen-Tao Huang Ming-Kun Chen Liao-Yuan Chun-Kui Shao 4 Ying-Hong Feng 2 Xin Gao Department of Urology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China Pharmacology, Uniformed Services University Health Sciences, Bethesda MD20814, USA First Hospital Nan Chang Nanchang 330006, Pathology, These authors have contributed equally to this work Correspondence to: Gao,...
OBJECTIVES: This study was aimed to explore Cdc20 expression and its correlation with clinicopathological characteristics biochemical recurrence (BCR) after laparoscopic radical prostatectomy (LRP) in clinically localized prostate cancer (PCa). METHODS: examined by immunohi stochemistry 166 cases, including 60 cases of benign hyperplasia (BPH) patients treated transurethral resection 106 consecutive PCa LRP without neoadjuvant therapy a single Chinese institution. The features the predictive...
The role of cell division cycle 20 (CDC20) was investigated in chemoresistance to decetaxel and the underlying mechanisms metastatic castration-resistant prostate cancer (mCRPC). MTT assays were performed determine effects siRNA-mediated CDC20 knockdown on proliferation anticancer activity docetaxel. Western blot analyses conducted detect changes Akt Wnt signaling. Furthermore, vivo growth PCa examined nude mice treated with siCDC20 or docetaxel alone combination. overexpressed mCRPC cells....
Controlled releasing of regulations remains the most convenient method to deliver various drugs. In present study, we precipitated gold nanoparticles with chrysophanol. The gold-chrysophanol into poly (DL-lactide-co-glycolide) was loaded and biological activity chrysophanol on human LNCap prostate cancer cells, tested acquire sustained property. circular dichroism spectroscopy indicated that effectively resulted in conformational alterations DNA regulated different proteins associated cell...
Damaged cartilage has very low regenerative potential which led to the search for novel tissue-engineering approaches help treat defects. While various have been reported, there is no perfect treatment currently. In this study we evaluated effects of a plant extract, chlorogenic acid (CGA), as part chondrocyte transplantation on model knee joint injury in chicks. First, primary cultured chondrocytes used evaluate CGA chondrogenesis. Then using an articular chick assessed functional recovery...
Abstract Background Aging is one of the dominant factors contributing to erectile dysfunction (ED), and effective treatments for age-associated ED are urgently demanded. In this study, therapeutic efficiency bone marrow-derived mesenchymal stem cells (BMSCs) overexpressing microRNA-145 (miR-145) was evaluated in ED. Methods Sixty male Sprague-Dawley rats (24 months old) were randomly divided into 4 treatment groups ( n = 15/group): PBS (control), BMSCs, BMSCs transfected with a blank vector...
Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies. found be expressed a variety of malignant tumors. In this study, we investigated the histologic colorectal or breast cancers, as well relationship between and proteinuria cancers. A total 101 enrolled 81 them had cancer 20 cancer. detected by immunohistochemical staining tumor tissues....